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Gallopamil dihydrochloride

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Identification
Molecular formula
C28H41Cl2N1O8
CAS number
16662-47-8
IUPAC name
3-[methyl-[2-[methyl-[3-(3,4,5-trimethoxybenzoyl)oxypropyl]amino]ethyl]amino]propyl 3,4,5-trimethoxybenzoate;dihydrochloride
State
State

At room temperature, gallopamil dihydrochloride is in a solid state. This compound is stable under standard conditions of temperature and pressure, and it is typically handled as a dry solid to prevent moisture absorption.

Melting point (Celsius)
142.00
Melting point (Kelvin)
415.00
Boiling point (Celsius)
600.00
Boiling point (Kelvin)
873.00
General information
Molecular weight
579.61g/mol
Molar mass
579.6130g/mol
Density
1.2000g/cm3
Appearence

Gallopamil dihydrochloride typically appears as a white to off-white crystalline powder. The crystalline nature of the compound is noted for its fine texture and sometimes slightly granular structure depending on the specific preparation method.

Comment on solubility

Solubility of 3-[methyl-[2-[methyl-[3-(3,4,5-trimethoxybenzoyl)oxypropyl]amino]ethyl]amino]propyl 3,4,5-trimethoxybenzoate; dihydrochloride

The compound 3-[methyl-[2-[methyl-[3-(3,4,5-trimethoxybenzoyl)oxypropyl]amino]ethyl]amino]propyl 3,4,5-trimethoxybenzoate; dihydrochloride (C28H41Cl2N1O8) exhibits notable solubility characteristics that are influenced by its unique molecular structure and the presence of dihydrochloride as a counter-ion.

Key Factors Affecting Solubility:

  • Ionic Strength: The dihydrochloride form implies enhanced solubility in polar solvents like water, due to the ionic interactions.
  • Polar Functional Groups: The presence of multiple methoxy groups (–OCH3) enhances solubility in organic solvents and promotes hydrogen bonding.
  • Large Hydrophobic Regions: The presence of the 3,4,5-trimethoxybenzoyl moiety creates substantial hydrophobic character, which can limit aqueous solubility.

Thus, this compound is expected to demonstrate:

  1. High solubility in polar organic solvents due to its polar functional groups.
  2. Enhanced solubility in aqueous solutions because of the ionic nature from the dihydrochloride.
  3. Reduced solubility in non-polar solvents, owing to its bulky hydrophobic regions.

Overall, the solubility of this compound reflects a balance between its hydrophilic and hydrophobic characteristics, making it a fascinating subject for further solubility studies!

Interesting facts

Interesting Facts about 3-[methyl-[2-[methyl-[3-(3,4,5-trimethoxybenzoyl)oxypropyl]amino]ethyl]amino]propyl 3,4,5-trimethoxybenzoate; dihydrochloride

This compound is a fascinating example of modern pharmaceutical chemistry, showcasing the intricate relationship between molecular structure and biological activity. Here are some intriguing aspects:

  • Complex Structure: The compound features multiple functional groups, including methoxy groups and a benzoyl moiety, which contribute to its potential pharmacological properties.
  • Mechanism of Action: Studies suggest that compounds like this one may interact with specific biological targets, influencing pathways related to neurotransmission or receptor activity, which makes them valuable in drug design.
  • Synthetic Challenges: The synthesis of this compound likely involves multi-step reactions, potentially including protective group strategies to build the complex structure gradually.
  • Potential Therapeutic Applications: Due to its structural features, this compound could be explored for applications in treating various conditions, such as psychiatric disorders or neurological diseases.
  • Inspiring Research: This compound could serve as a lead structure for the development of new drugs, stimulating ongoing research into derivatives that optimize efficacy and safety profiles.

The continuous exploration of compounds like this exemplifies the beauty and complexity of chemistry, where each molecular configuration holds the potential to unlock new therapeutic avenues. As researchers delve deeper into its properties and mechanisms, they may reveal new insights that could lead to significant advancements in medicine.

Synonyms
Hexobendine dihydrochloride
50-62-4
Andiamine
Ustimon
Reoxyl
Flussicor
Hexobendine HCl
UNII-P60CS4TIHV
P60CS4TIHV
EINECS 200-054-7
HEXOBENDINE HYDROCHLORIDE
Benzoic acid, 3,4,5-trimethoxy-, 1,2-ethanediylbis((methylimino)-3,1-propanediyl) ester, 2HCl
N,N'-Dimethyl-N,N'-bis(3-(3',4',5'-trimethoxybenzoxy)propyl)ethylenediamine dihydrochloride
3-[methyl-[2-[methyl-[3-(3,4,5-trimethoxybenzoyl)oxypropyl]amino]ethyl]amino]propyl 3,4,5-trimethoxybenzoate;dihydrochloride
ST-7090
HEXOBENDINE DIHYDROCHLORIDE [MI]
HEXOBENDINE HYDROCHLORIDE [WHO-DD]
Benzoic acid, 3,4,5-trimethoxy-, diester with 3,3'-(ethylenebis(methylimino))di-1-propanol, dihydrochloride
(Ethane-1,2-diylbis(methylazanediyl))bis(propane-3,1-diyl) bis(3,4,5-trimethoxybenzoate) dihydrochloride
hexobendine dihy-drochloride
SCHEMBL317378
DTXSID90964485
GIOKUMNZQFCEPI-UHFFFAOYSA-N
FH23820
3-[methyl-[2-[methyl-[3-(3,4,5-trimethoxybenzoyl)oxypropyl]amino]ethyl]amino]propyl3,4,5-trimethoxybenzoate dihydrochloride
NS00078835
Q27286267
(Ethane-1,2-diyl)bis[(methylazanediyl)propane-3,1-diyl] bis(3,4,5-trimethoxybenzoate)--hydrogen chloride (1/2)
200-054-7
3,4,5-Trimethoxybenzoic acid 1,2-ethanediylbis[(methylimino)-3,1-propanediyl] ester dihydrochloride;3,3'-[Ethylenebis(methylimino)]d i-1-propanol bis(3,4,5-trimethoxybenzoate) (ester) dihydrochloride;Andiamine