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3-methyl-2,4,5,6-tetrahydro-1H-azepino[4,5-b]indole

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Identification
Molecular formula
C12H14N2
CAS number
29838-67-3
IUPAC name
3-methyl-2,4,5,6-tetrahydro-1H-azepino[4,5-b]indole
State
State

At room temperature, 3-methyl-2,4,5,6-tetrahydro-1H-azepino[4,5-b]indole is a solid compound. It is stable under normal conditions and does not quickly absorb moisture from the environment.

Melting point (Celsius)
189.30
Melting point (Kelvin)
462.45
Boiling point (Celsius)
412.50
Boiling point (Kelvin)
685.65
General information
Molecular weight
186.26g/mol
Molar mass
186.2580g/mol
Density
1.1567g/cm3
Appearence

3-methyl-2,4,5,6-tetrahydro-1H-azepino[4,5-b]indole typically presents as a pale yellow to off-white solid. When it is pure, it appears crystalline in structure and finely particulate.

Comment on solubility

Solubility of 3-methyl-2,4,5,6-tetrahydro-1H-azepino[4,5-b]indole

The solubility of 3-methyl-2,4,5,6-tetrahydro-1H-azepino[4,5-b]indole is influenced by several chemical and physical factors intrinsic to its structure. This compound, being a bicyclic amine derivative, typically exhibits the following characteristics regarding solubility:

  • Polar vs. Nonpolar: Due to its hybrid structure, the compound has polar functional groups which can enhance solubility in polar solvents such as water and alcohol. However, its hydrophobic aromatic rings may limit solubility in highly polar environments.
  • Temperature Sensitivity: Like many organic compounds, the solubility of this tetrahydroindole derivative may increase with rising temperatures, enabling greater interaction with solvent molecules.
  • Concentration Dependence: The solubility can be affected by the concentration of other solutes in the solution. It may be less soluble in very concentrated conditions due to competitive solvation.
  • pH Levels: The ionization state of the compound can change with pH levels, potentially enhancing or reducing solubility in aqueous environments.

Given these factors, one could summarize the solubility behavior of 3-methyl-2,4,5,6-tetrahydro-1H-azepino[4,5-b]indole as **moderately soluble**, with potential variations depending on the solvent choice and external conditions. Understanding these elements can be crucial for applications in pharmacology or biochemical fields where solubility properties significantly influence bioavailability and functionality.

Interesting facts

Interesting Facts about 3-Methyl-2,4,5,6-tetrahydro-1H-azepino[4,5-b]indole

The compound 3-methyl-2,4,5,6-tetrahydro-1H-azepino[4,5-b]indole is a fascinating member of a class of compounds known for their interesting structural features and potential applications in the field of medicinal chemistry. Here are some intriguing aspects:

  • Complex Structure: The unique bicyclic framework of this compound, which incorporates both an indole and an azepine moiety, contributes to its intricate chemical properties and reactivity.
  • Biosynthetic Relevance: Many indole derivatives are known to play critical roles in biological systems, often serving as precursors for essential biomolecules such as neurotransmitters and hormones.
  • Pharmacological Potential: Compounds with similar structures have shown activity in various biological assays, making this azepino[4,5-b]indole derivative a potential candidate for drug development targeting conditions such as anxiety and depression.
  • Chemical Versatility: The presence of multiple functional groups opens avenues for further chemical modifications, leading to the possibility of creating derivatives with enhanced pharmacological profiles.
  • Research Interest: Due to its structural complexity and potential biological activity, this compound is of interest in ongoing research aimed at synthesizing new compounds for therapeutic use.

In the realm of organic chemistry, understanding such compounds extends beyond their physical properties, as their complex interactions and potential utility in pharmaceuticals highlight the importance of research in this area. As chemists continue to explore the universe of indole and azepine derivatives, the insights gained can significantly contribute to advancements in medicinal chemistry.

As a budding chemist or enthusiast, studying compounds like this can be both challenging and rewarding. The synthesis and study of these intriguing molecules exemplify the art and science of chemistry.

Synonyms
7546-66-9
3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole
BRN 0958568
AZEPINO(4,5-b)INDOLE, 1,2,3,4,5,6-HEXAHYDRO-3-METHYL-
1,2,3,4,5,6-Hexahydro-3-methylazepino(4,5-b)indole
3-Methyl-1,2,3,4,5,6-hexahydroazepino(4,5-b)indole
DTXSID70226391
5-23-07-00376 (Beilstein Handbook Reference)
DTXCID70148882
3-methyl-2,4,5,6-tetrahydro-1H-azepino[4,5-b]indole
SCHEMBL8260736
AKOS027421043
F95491
3-methyl-1,2,3,4,5,6-hexahydro-azepino[4,5-b]indole