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Zolmitriptan Hydrochloride

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Identification
Molecular formula
C16H22ClN3O
CAS number
139264-17-8
IUPAC name
3-methyl-3-[3-(methylamino)propyl]-1-phenyl-indolin-2-one;hydrochloride
State
State

At room temperature, Zolmitriptan Hydrochloride is in a solid state. It is commonly used in pharmaceutical formulations in tablet or nasal spray forms due to its effectiveness in treating migraine headaches.

Melting point (Celsius)
136.50
Melting point (Kelvin)
409.65
Boiling point (Celsius)
250.00
Boiling point (Kelvin)
523.15
General information
Molecular weight
362.88g/mol
Molar mass
362.8810g/mol
Density
1.2000g/cm3
Appearence

Zolmitriptan Hydrochloride appears as a white to off-white crystalline powder. It is generally odorless and has a slightly bitter taste. The compound is typically presented as a solid in its hydrochloride salt form, which assists with its stability and solubility as a pharmaceutical agent.

Comment on solubility

Solubility of 3-methyl-3-[3-(methylamino)propyl]-1-phenyl-indolin-2-one; hydrochloride

The solubility of 3-methyl-3-[3-(methylamino)propyl]-1-phenyl-indolin-2-one; hydrochloride is a key factor in its applications and behavior in various environments. Understanding its solubility characteristics can provide insight into its usage in pharmaceuticals and chemical processes. Here are some points to consider:

  • Solvent Dependence: The solubility of this compound can vary significantly depending on the solvent used. It tends to be more soluble in polar solvents such as water and alcohol due to the presence of the hydrochloride salt.
  • pH Sensitivity: As a hydrochloride salt, it may exhibit solubility changes with pH variations, thus influencing its bioavailability and reactivity in biological systems.
  • Temperature Effects: Generally, solubility can increase with temperature. So, higher temperatures may promote dissolution, which is critical when considering its formulation in drug delivery systems.
  • Crystallization: The crystallization behavior of this compound may affect its solubility, particularly in maintaining consistent pharmaceutical formulations.

In summary, the solubility of 3-methyl-3-[3-(methylamino)propyl]-1-phenyl-indolin-2-one; hydrochloride is influenced by several factors typically observed in ionic compounds. Understanding and optimizing these factors can facilitate its effective use in various scientific and medicinal applications.

Interesting facts

Interesting Facts about 3-Methyl-3-[3-(methylamino)propyl]-1-phenyl-indolin-2-one; Hydrochloride

3-Methyl-3-[3-(methylamino)propyl]-1-phenyl-indolin-2-one; hydrochloride is a unique compound that belongs to the class of indolinones. Here are some noteworthy points about this fascinating molecule:

  • Pharmacological Relevance: This compound has garnered interest in the field of medicinal chemistry due to its potential use as a therapeutic agent. It exhibits properties that could be useful in various medical applications.
  • Structural Features: The indolinone scaffold is notable for its diverse biological activities. The presence of the phenyl group adds to its stability and bioactivity, making it a point of interest in drug design.
  • Potential as a Drug Candidate: Research indicates that analogs of this compound may act on important biological pathways, potentially serving as leads in the development of new drugs. One area of research focuses on its neuroprotective properties.
  • Research Usage: It is often utilized in studies aimed at understanding structure-activity relationships (SAR) within organic chemistry and pharmacology. The variations in substituents can lead to significant changes in activity, showcasing the importance of fine-tuning chemical structures.
  • Complex Synthesis: The synthesis of this compound requires advanced organic chemistry techniques, highlighting the creativity and skill of chemists in producing complex molecules.

The integration of the methylamino group introduces an additional layer of functionality, which can influence solubility and interaction with biological targets. As researchers explore this compound further, it promises to unveil exciting insights into drug design and therapeutic possibilities. In the words of a renowned chemist, "The beauty of chemistry lies in its ability to unravel the mysteries of life"—and compounds like this one exemplify that promise.


Synonyms
AMEDALIN HYDROCHLORIDE
Amedalin HCl
22232-73-1
Amedalin hydrochloride [USAN]
UNII-0EMF539HN0
0EMF539HN0
UK-3540-1
Amedalin hydrochloride (USAN)
UK 3540-1
3-Methyl-3-(3-(methylamino)propyl)-1-phenyl-2-indolinon hydrochlorid
2H-Indol-2-one, 1,3-dihydro-3-methyl-3-(3-(methylamino)propyl)-1-phenyl-, monohydrochloride
3-Methyl-3-(3-(methylamino)propyl)-1-phenyl-2-indolinone monohydrochloride
3-Methyl-3-[3-(methylamino)propyl]-1-phenyl-2-indolinone monohydrochloride
RefChem:111889
3-methyl-3-[3-(methylamino)propyl]-1-phenylindol-2-one;hydrochloride
orb1986563
CHEMBL2105957
SCHEMBL29365804
DTXSID80944877
AKOS040750400
D02891
Q27236685
3-Methyl-3-[3-(methylamino)propyl]-1-phenyl-1,3-dihydro-2H-indol-2-one--hydrogen chloride (1/1)