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Nitrofurazone

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Identification
Molecular formula
C6H6N4O4
CAS number
59-87-0
IUPAC name
3-methyl-5-(5-nitro-2-furyl)isoxazole-4-carboxamide
State
State

At room temperature, nitrofurazone is a solid. It is often encountered in finely divided powder form, which makes it suitable for application as an antimicrobial agent in medical settings.

Melting point (Celsius)
236.00
Melting point (Kelvin)
509.15
Boiling point (Celsius)
246.00
Boiling point (Kelvin)
519.15
General information
Molecular weight
198.14g/mol
Molar mass
198.1410g/mol
Density
1.6300g/cm3
Appearence

Nitrofurazone typically appears as a yellow crystalline solid. It is often found in powdered form and is known for its distinctive color, which makes it easily identifiable. The compound is used for its antimicrobial properties, often in topical formulations.

Comment on solubility

Solubility of 3-methyl-5-(5-nitro-2-furyl)isoxazole-4-carboxamide

The solubility of 3-methyl-5-(5-nitro-2-furyl)isoxazole-4-carboxamide can be influenced by several factors:

  • Polarity: The presence of the carboxamide and nitro groups contributes to the overall polarity of the compound, which may enhance its solubility in polar solvents such as water.
  • Hydrogen Bonding: This compound can engage in hydrogen bonding due to its carboxamide functional group, which typically increases solubility in polar solvents.
  • Structural Considerations: The overall structure of the isoxazole ring may influence how well the compound fits into the solvent matrix, which can affect solubility.
  • Solvent Choice: Depending on the solvent used, the solubility can vary widely. For instance, it may have different solubility profiles in organic solvents compared to water.

In summary, while 3-methyl-5-(5-nitro-2-furyl)isoxazole-4-carboxamide is likely to exhibit moderate solubility owing to its functional groups, specific quantitative solubility data would be essential for precise applications. Understanding these solubility characteristics is pivotal for both synthetic and pharmaceutical contexts.

Interesting facts

Exploring 3-Methyl-5-(5-Nitro-2-Furyl)IsOxazole-4-Carboxamide

3-Methyl-5-(5-nitro-2-furyl)isoxazole-4-carboxamide is an intriguing compound within the realm of organic chemistry. Here are some interesting facts that highlight its significance:

  • Structure and Function: The compound contains an isoxazole ring, which is known for its diverse biological activities. This unique structure makes it a point of interest for medicinal chemists.
  • Biological Activity: Compounds similar to 3-methyl-5-(5-nitro-2-furyl)isoxazole-4-carboxamide have been studied for their potential pharmaceutical applications, particularly as anti-inflammatory agents and antimicrobial agents.
  • Substituents Matter: The nitro group on the furan ring plays a critical role in enhancing the compound's reactivity. This makes the compound a useful candidate for further modifications and synthesis of related compounds.

One prominent feature of this compound is its potential to interact with biological mechanisms, which is reflected in various studies that explore derivative compounds for therapeutic uses. As a fellow scientist once said, “The structure of a compound tells its story, revealing the mysteries of its interactions.”

Furthermore, the **5-nitro-2-furyl** group can impart unique electronic properties that may contribute to the compound's reactivity and stability. Researchers are keen on studying the electronic characteristics of compounds like this, owing to their implications in formulation and design of new drugs.

In light of its versatility and potential applications, 3-methyl-5-(5-nitro-2-furyl)isoxazole-4-carboxamide serves as a reminder of the rich possibilities available in the world of organic synthesis and pharmaceuticals.

Synonyms
22997-01-9
4-ISOXAZOLECARBOXAMIDE, 3-METHYL-5-(5-NITRO-2-FURYL)-
3-Methyl-5-(5-nitro-2-furyl)-4-isoxazolecarboxamide
DTXSID10177550