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Metronidazole

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Identification
Molecular formula
C4H6N4O2
CAS number
443-48-1
IUPAC name
3-methyl-5-nitro-imidazol-4-amine
State
State

At room temperature, Metronidazole is in a solid state, characterized by its crystalline powder form.

Melting point (Celsius)
159.00
Melting point (Kelvin)
432.15
Boiling point (Celsius)
256.00
Boiling point (Kelvin)
529.15
General information
Molecular weight
145.11g/mol
Molar mass
145.1110g/mol
Density
1.4545g/cm3
Appearence

Metronidazole typically appears as a white to slightly yellow crystalline powder. It is generally odorless and has a slightly bitter taste.

Comment on solubility

Solubility of 3-methyl-5-nitro-imidazol-4-amine

The solubility of 3-methyl-5-nitro-imidazol-4-amine in various solvents can significantly influence its applications and reactivity in chemical processes. When exploring its solubility, consider the following aspects:

  • Water Solubility: This compound exhibits moderate solubility in water, which is essential for its use in biological systems.
  • Organic Solvents: It is more soluble in organic solvents such as DMSO and ethanol, making it an excellent candidate for applications requiring a non-aqueous medium.
  • Temperature Influence: Solubility can increase with temperature, thus experimental conditions should consider thermal variations.

As 3-methyl-5-nitro-imidazol-4-amine is characterized by its polar functional groups, it can interact favorably with polar solvents, which aids in its dissolution. This characteristic enhances its bioavailability and potential efficacy in various chemical applications.

In summary, the solubility of 3-methyl-5-nitro-imidazol-4-amine plays a critical role in its functional usage, highlighting the necessity for thorough exploration under varying solvent environments and conditions.

Interesting facts

Interesting Facts About 3-Methyl-5-Nitro-Imidazol-4-Amine

3-Methyl-5-nitro-imidazol-4-amine is a fascinating compound with significant implications in various fields, especially in medicinal chemistry. Below are some notable facts:

  • Pharmaceutical Potential: This compound serves as a precursor in the synthesis of various pharmaceuticals, notably as an intermediate in the development of anti-parasitic and anti-fungal agents.
  • Imidazole Ring: The imidazole group is a five-membered heterocyclic ring that plays a crucial role in the biological activity of many biomolecules. It’s found in important compounds such as histidine, a vital amino acid.
  • Nitro Group Reactivity: The nitro group in this compound gives it unique chemical properties, making it a target for reduction reactions. This can lead to the formation of amines, which are often more biologically active.
  • Research Interest: The nitro-imidazole derivatives have been the subject of numerous studies due to their effectiveness against parasites and their potential role in hypoxic cell sensitization in cancer therapy.
  • Environmental Insight: Interesting to note, compounds similar to 3-methyl-5-nitro-imidazol-4-amine can be found in some environmental studies, particularly regarding soil and water contaminants due to their synthetic production.

In summary, 3-methyl-5-nitro-imidazol-4-amine not only provides insights into pharmaceutical development but also underscores the importance of chemical reactivity and biological applications. The ongoing research around this compound continues to pave the way for innovative therapeutic strategies.

Synonyms
4531-54-8
1-METHYL-4-NITRO-1H-IMIDAZOL-5-AMINE
5-amino-1-methyl-4-nitroimidazole
UNII-55UIE6811G
55UIE6811G
NSC-400013
DTXSID70196469
NSC 400013
1H-Imidazol-5-amine, 1-methyl-4-nitro-
AZATHIOPRINE IMPURITY A [EP IMPURITY]
IMIDAZOLE, 5-AMINO-1-METHYL-4-NITRO-
AZATHIOPRINE IMPURITY A (EP IMPURITY)
DTXCID30118960
813-053-7
3-methyl-5-nitroimidazol-4-amine
1H-Imidazol-5-amine,1-methyl-4-nitro-(9CI)
1H-Imidazol-5-amine, 1-methyl-4-nitro-; Imidazole, 5-amino-1-methyl-4-nitro- (7CI,8CI); 1-Methyl-4-nitro-1H-imidazol-5-amine; 5-Amino-1-methyl-4-nitroimidazole; NSC 400013
NSC400013
3-Methyl-5-nitro-3H-imidazol-4-ylamine
BAS 00291726
Oprea1_562439
SCHEMBL2871452
GJVMTMXQJDQJSS-UHFFFAOYSA-N
5-amino-1-methyl-4-nitroimid-azole
STK834386
AKOS000601547
FA31238
AS-76126
1-Methyl-4-nitro-1H-imidazol-5-amine #
CS-0151159
D95001
EN300-249675
Q27261340
Z57124101