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Fostamatinib

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Identification
Molecular formula
C26H30ClNO4
CAS number
914295-16-2
IUPAC name
3-methyl-6-(morpholin-4-ium-4-ylmethyl)-2-phenyl-chromen-4-one;chloride
State
State

At room temperature, Fostamatinib chloride is typically a solid powder. It is stable under normal conditions but should be stored in a dry, well-ventilated place to prevent hydration.

Melting point (Celsius)
230.00
Melting point (Kelvin)
503.15
Boiling point (Celsius)
409.00
Boiling point (Kelvin)
682.15
General information
Molecular weight
541.00g/mol
Molar mass
540.9960g/mol
Density
1.2121g/cm3
Appearence

Fostamatinib chloride appears as a pale yellow to beige crystalline powder. The compound is often provided in its hydrated form and may absorb moisture when exposed to air.

Comment on solubility

Solubility of 3-methyl-6-(morpholin-4-ium-4-ylmethyl)-2-phenyl-chromen-4-one;chloride

The solubility of the compound 3-methyl-6-(morpholin-4-ium-4-ylmethyl)-2-phenyl-chromen-4-one;chloride is influenced by several factors, including its structure and ionic properties. Here are some key points regarding its solubility:

  • Polarity: The presence of the morpholinium group indicates that this compound may exhibit pronounced ionic characteristics, which often enhances solubility in polar solvents, such as water.
  • Hydrogen Bonding: The morpholinium part can participate in hydrogen bonding, potentially increasing solubility in aqueous environments. This can lead to higher interaction with water molecules.
  • Solvent Interaction: While the chloride ion contributes to solubility in water, the entire chromenone structure may have varying degrees of solubility depending on the solvent used. Non-polar solvents could exhibit reduced solubility.
  • Temperature Effects: As with many compounds, temperature plays a critical role; increased temperature may enhance solubility in certain solvents.
  • Ionization: Being a quaternary ammonium compound, it is likely to be ionized in solution, which can promote solubility in environments where ionic interactions are favored.

In general, this compound is anticipated to be more soluble in polar solvents compared to non-polar solvents. However, the actual solubility can vary significantly based on the specific environmental conditions, such as pH and temperature. Understanding these factors is essential for applications where solubility is a critical parameter.

Interesting facts

Interesting Facts about 3-Methyl-6-(morpholin-4-ium-4-ylmethyl)-2-phenyl-chromen-4-one; Chloride

This complex compound, classified as a chromone derivative, boasts a unique structure that combines features of both chromones and morpholinium compounds. Its molecular architecture not only contributes to its intriguing chemical properties but also paves the way for exciting applications in various fields.

Key Features:

  • Biological Significance: Many chromone derivatives, including this compound, are known for their diverse biological activities, such as anti-inflammatory, antioxidant, and anticancer properties. This makes them attractive candidates for pharmaceutical research.
  • Synthetic Versatility: The presence of the morpholinium moiety opens up pathways for the creation of derivatives with modified functionality. This versatility can lead to the development of novel compounds with enhanced therapeutic profiles.
  • Research Potential: The compound holds promise in medicinal chemistry as a scaffold for drug development. Research into its potential interactions with biological targets could uncover new treatments for various diseases.
  • Interdisciplinary Applications: Its unique structure may also have implications in fields such as materials science and organic electronics, given the growing interest in organic semiconductors and advanced materials.

As scientists delve deeper into understanding the properties and potential of this compound, it highlights the importance of exploring the vast landscape of chemical compounds. As the famous chemist Linus Pauling once said, "The best way to have a good idea is to have a lot of ideas." Exploring such complex structures is crucial for innovation and discovery in science.

Synonyms
REC 7-0078
3-Methyl-6-morpholinomethyl-flavone hydrochloride
16146-83-1
3-Metil-6-morfolinometil-flavone-cloridrato [Italian]
3-Metil-6-morfolinometil-flavone-cloridrato
FLAVONE, 3-METHYL-6-MORPHOLINOMETHYL-, MONOHYDROCHLORIDE