3-(Methylamino)indolin-2-one | Solubility of Things

Identification

Molecular formula

C₉H₁₀N₂O

CAS number

4449-54-3

IUPAC name

3-(methylamino)indol-2-one

State

At room temperature, 3-(Methylamino)indol-2-one exists as a solid. It is typically characterized by its crystalline structure.

Melting point (Celsius)

105.00

Melting point (Kelvin)

378.15

Boiling point (Celsius)

370.00

Boiling point (Kelvin)

643.15

General information

Molecular weight

160.19g/mol

Molar mass

160.1880g/mol

Density

1.2789g/cm³

Appearence

3-(Methylamino)indol-2-one typically appears as a pale yellow to brown crystalline solid. The compound's crystalline nature can lead to variations in color intensity, but it should generally be free from any visible impurities or discoloration.

Comment on solubility

Solubility of 3-(methylamino)indol-2-one

3-(methylamino)indol-2-one exhibits fascinating solubility characteristics that are crucial for its applications in various fields. This compound is known to be:

Soluble in organic solvents: It readily dissolves in a range of organic solvents such as methanol, ethanol, and dimethyl sulfoxide (DMSO).
Insoluble in water: Its solubility in water is limited, which poses challenges for applications where aqueous solutions are required.

The limited water solubility can often be attributed to its structural features. For instance, the presence of the indole moiety, which is typically hydrophobic, contributes to its overall behavior in aqueous environments. Therefore, when considering the compound's practical uses, it's important to keep the following points in mind:

pH Dependence: Solubility may vary with changes in pH, as protonation of the amino group can enhance solubility in more acidic conditions.
Temperature Effects: Increased temperature generally enhances solubility in organic solvents, while the effect in water can be variable.
Formulation Considerations: For applications requiring aqueous solutions, formulating with surfactants or co-solvents could aid in enhancing solubility.

In conclusion, understanding the solubility of 3-(methylamino)indol-2-one is essential for harnessing its potential in practical applications. Knowing that it is soluble in organic solvents but not in water allows researchers and formulators to make informed decisions in their work.

Interesting facts

Interesting Facts about 3-(Methylamino)indol-2-one

3-(Methylamino)indol-2-one is a fascinating compound that presents a rich area of study in the field of organic chemistry. Here are some notable aspects:

Structural Significance: This compound features an indole backbone, which is a common motif in many natural products and pharmaceuticals. The presence of the methylamino group contributes to its unique chemical properties.
Biological Relevance: Compounds containing indole derivatives, including 3-(methylamino)indol-2-one, are often investigated for their biological activities. They have shown potential in areas such as antimicrobial and anticancer research.
Synthetic Applications: This compound can be utilized as a building block in the synthesis of more complex organic molecules, which may have significant pharmacological properties. The ability to modify the methylamino group allows for a variety of derivatives to be created, enhancing its utility in medicinal chemistry.

Researchers are particularly interested in how the modifications to the indole structure can lead to compounds with specific interactions in biological systems. According to a recent study, "the indole framework is a versatile platform that enables diverse functionalization, leading to compounds with tailored biological activity."

In conclusion, 3-(methylamino)indol-2-one is not just a simple chemical compound; it embodies the essence of chemical innovation in drug discovery. The interaction of its functional groups with biological targets makes it an exciting area of study for scientists eager to uncover novel therapeutic agents.