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Isovaleramide

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Identification
Molecular formula
C5H11NO
CAS number
541-47-9
IUPAC name
3-methylbutanamide
State
State

At room temperature, isovaleramide can be either a liquid or a crystalline solid. Its state can vary due to slight changes in temperature around the room temperature range.

Melting point (Celsius)
36.00
Melting point (Kelvin)
309.15
Boiling point (Celsius)
206.40
Boiling point (Kelvin)
479.55
General information
Molecular weight
101.16g/mol
Molar mass
101.1600g/mol
Density
0.9192g/cm3
Appearence

Isovaleramide appears as a colorless to pale yellow liquid or solid, depending on the purity and specific storage conditions. It has a faint, characteristic amine-like odor.

Comment on solubility

Solubility of 3-methylbutanamide

3-methylbutanamide, a derivative of butanoic acid, presents interesting solubility characteristics primarily due to its functional groups. Understanding the solubility behavior of this compound requires consideration of several factors:

  • Polarity: 3-methylbutanamide contains an amide functional group, which is polar. This characteristic significantly enhances its solubility in polar solvents, particularly water, when compared to nonpolar substances.
  • Hydrogen Bonding: The presence of the amide group allows for the formation of hydrogen bonds with water molecules. This interaction plays a crucial role in its ability to dissolve.
  • Alkyl Chain Influence: The branched nature of the 3-methylbutane portion provides some hydrophobic characteristics; however, the amide's polarity generally dominates. Therefore, while the compound is capable of dissolving in aqueous solutions, its solubility might be limited relative to simpler and smaller amides.

In conclusion, while 3-methylbutanamide exhibits solubility in polar solvents like water, its overall solubility is influenced by the balance between its hydrophilic amide group and hydrophobic alkyl structure. To summarize, one can say:

"More hydrogen bonding leads to increased solubility in polar solvents, while larger alkyl groups can hinder this interaction."
Interesting facts

Interesting Facts About 3-Methylbutanamide

3-Methylbutanamide, also known as isopropyl 4-aminobutanoate, is a fascinating organic compound with diverse applications in various fields of science and industry. Here are some compelling insights:

  • Structural Diversity: 3-Methylbutanamide is classified as an amide, which is a functional group characterized by the presence of a carbonyl group (C=O) bonded to a nitrogen atom (N). This particular structure imparts unique reactivity to the compound.
  • Biological Relevance: Amides play an essential role in biochemistry; they are found in amino acids and proteins. This makes compounds like 3-methylbutanamide valuable in biological research and pharmaceuticals.
  • Synthesis Insights: This compound can be synthesized through various methods, including the reaction of 3-methylbutanoic acid with an appropriate amine. The ability to tailor the synthesis route can lead to variations in substituents and functionalities.
  • Flavor and Fragrance: Compounds in the amide family, including 3-methylbutanamide, can contribute to flavors and fragrances. They are utilized in the formulation of food and cosmetic products, enhancing their sensory appeal.
  • Research Applications: Its utility in research underscores its significance; it can serve as a precursor for the development of more complex molecules or drug candidates.

In summary, 3-methylbutanamide exemplifies the interconnectedness of chemistry and biology, revealing how small molecular changes can lead to significantly different properties and applications. As one delves deeper into the world of this compound, one may discover further mysteries and potentials yet to be explored!

Synonyms
ISOVALERAMIDE
3-Methylbutanamide
541-46-8
Butanamide, 3-methyl-
Isopentanamide
Isovaleric amide
Isovaleric acid amide
beta-Methylbutyramide
Isovaleramide [USAN]
NFS1776
NPS 1776
.beta.-Methylbutyramide
EINECS 208-781-1
UNII-9CP4KB634M
3-methylbutaneamide
NSC 402555
NSC-402555
BRN 1740789
9CP4KB634M
Isovaleramide (USAN)
NFS-1776
ISOVALERAMIDE [MI]
DTXSID3060249
DTXCID7041596
208-781-1
4-02-00-00902 (beilstein handbook reference)
sanouvwgpvyvav-uhfffaoysa-n
3-Methylbutyramide
NPS-1776
3-methyl-butanamide
MFCD00014807
SCHEMBL9641
CHEMBL171066
CHEBI:229314
HMS3264B03
HMS3652O16
HMS3885H05
Pharmakon1600-01506177
BCP05941
HY-B1229
BDBM50224817
NSC402555
NSC760408
s4116
AKOS008937702
CCG-213627
CS-4876
NSC-760408
AS-14001
DB-357220
NS00032973
SW220069-1
C75541
D04637
AB01563345_01
AB01563345_02
EN300-1232898
Q6086595
BRD-K90069354-001-01-1
BRD-K90069354-001-02-9
BRD-K90069354-001-03-7
BRD-K90069354-001-04-5
Z33546511
F1995-0350