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3-Methylquinazolin-4-one

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Identification
Molecular formula
C9H8N2O
CAS number
17609-86-6
IUPAC name
3-methylquinazolin-4-one
State
State

At room temperature, 3-methylquinazolin-4-one is in a solid state. It is typically stable under standard conditions and is handled as a solid in most laboratory settings.

Melting point (Celsius)
187.00
Melting point (Kelvin)
460.15
Boiling point (Celsius)
351.00
Boiling point (Kelvin)
624.15
General information
Molecular weight
160.18g/mol
Molar mass
160.1780g/mol
Density
1.2103g/cm3
Appearence

3-Methylquinazolin-4-one is a solid chemical compound. It is typically white to off-white in appearance, and its crystalline structure may vary from powdery to granular forms, depending on its preparation and purity.

Comment on solubility

Solubility of 3-methylquinazolin-4-one

3-methylquinazolin-4-one, with its intriguing structure, presents interesting solubility characteristics that reflect its aromatic nature. Understanding its solubility can be essential for applications in chemical synthesis and medicinal chemistry.

Typically, the solubility of 3-methylquinazolin-4-one can be summarized as follows:

  • Solvent Compatibility: It is generally more soluble in organic solvents such as dichloromethane, ethanol, and acetic acid due to its hydrophobic aromatic ring.
  • Water Solubility: The compound shows limited solubility in water, reflecting its nonpolar character which hinders interactions with polar water molecules.
  • pH Influence: The solubility may also vary with pH changes, as protonation states of the nitrogen atoms in the quinazoline ring could affect its interactions.

As one delves deeper, it's critical to observe that "the solubility of a compound is often a balance between its molecular structure and the solvent's properties." This balance is what governs how 3-methylquinazolin-4-one behaves in different environments, making it a compound of interest for further studies.

In conclusion, while 3-methylquinazolin-4-one exhibits limited solubility in water, its compatibility with various organic solvents opens avenues for exploring its potential in chemical reactions and applications.

Interesting facts

Interesting Facts about 3-Methylquinazolin-4-one

3-Methylquinazolin-4-one is a fascinating compound that belongs to the quinazolinone family, a group known for their diverse biological activities. Here are some captivating insights into this intriguing molecule:

  • Medicinal Potential: Many derivatives of quinazolinones, including 3-methylquinazolin-4-one, have shown significant promise in medicinal chemistry, particularly as antitumor agents and antimicrobial substances.
  • Biological Activity: Research has indicated that compounds within this class can exhibit various biological properties, such as anti-inflammatory and antiviral activities, making them interesting candidates for drug development.
  • Versatile Synthesis: The synthesis of 3-methylquinazolin-4-one can be accomplished through various methods, including cyclization reactions, which can lead to the exploration of many synthetic pathways and enhance understanding of reaction mechanisms.
  • Pharmacophoric Features: The quinazolinone structure contains key pharmacophoric components, such as the carbonyl and nitrogen atoms, which can interact with biological targets, making them crucial in lead optimization for drug candidates.
  • Role in Research: Ongoing studies often explore modifications of the basic structure to improve efficacy and reduce toxicity, emphasizing the importance of structure-activity relationships (SAR) in pharmaceutical research.

In summary, 3-methylquinazolin-4-one stands out not only for its unique structure but also for its potential applications in fields ranging from medicinal chemistry to pharmacology. As research progresses, this compound could play an integral role in the development of new therapeutic agents that could benefit human health.

Synonyms
4(3H)-QUINAZOLINONE, 3-METHYL-
3-Methyl-4-quinazolinone
3-Methyl-4(3H)-quinazolinone
2E8G0QHA8T
NSC 401251
BRN 0124667
4-Quinazolone, 3-methyl
UNII-2E8G0QHA8T
NSC-401251
3-methyl-3,4-dihydroquinazoline-4-one
DTXSID10179099
5-24-03-00026 (Beilstein Handbook Reference)
DTXCID90101590
fjvaqpinjbfbli-uhfffaoysa-n
2436-66-0
3-Methylquinazolin-4(3H)-one
NSC401251
3-methyl-4-quinazolone
SCHEMBL122167
CHEMBL3139516
3-Methyl-4(3H)-quinazolinone #
AKOS006228107
quinazoline, 3,4-dihydro-3-methyl-4-oxo-
H37994