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Iopamidol

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Identification
Molecular formula
C17H22I3N3O7
CAS number
60166-93-0
IUPAC name
3-(N-(3-amino-2,4,6-triiodo-benzoyl)anilino)propanoic acid
State
State

At room temperature, Iopamidol is typically in a liquid state when prepared for use as a contrast agent. It is administered intravenously for imaging procedures, allowing for clear visibility of organs, blood vessels, and other internal structures during medical examinations.

Melting point (Celsius)
0.00
Melting point (Kelvin)
0.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
777.09g/mol
Molar mass
777.0940g/mol
Density
2.1100g/cm3
Appearence

Iopamidol appears as a colorless to pale yellow liquid or powder. It is an iodinated compound that is essentially odorless and is designed to be water-soluble for medical imaging purposes. As a contrast agent, it is often used in various concentrations during radiographic and computed tomography (CT) imaging procedures to enhance the contrast of bodily structures.

Comment on solubility

Solubility Characteristics

The compound 3-(N-(3-amino-2,4,6-triiodo-benzoyl)anilino)propanoic acid presents intriguing solubility features due to its complex structure and functional groups. Here are some key points to consider:

  • Polarity: The presence of multiple nitrogen and iodine atoms contributes to the overall polarity of the molecule, which can enhance solubility in polar solvents such as water.
  • Hydrophilicity: The amino (-NH2) and carboxylic acid (-COOH) groups present in the structure improve the hydrophilic character, allowing for potential solubility in aqueous environments.
  • Hydrophobic interactions: Despite its polar nature, the triiodo substituent may introduce some degree of hydrophobic properties, which could affect solubility depending on the solvent used.
  • Solvent compatibility: It is likely soluble in organic solvents such as dimethyl sulfoxide (DMSO) and ethanol due to its functional groups, but this can vary widely based on specific conditions.

In conclusion, the solubility of 3-(N-(3-amino-2,4,6-triiodo-benzoyl)anilino)propanoic acid is a complex interplay between its polar and non-polar regions, making it essential to perform thorough solubility tests in varying solvents to delineate its behavior accurately. As noted, "the solubility of a compound is often the key to its application in scientific research and practical use."

Interesting facts

Interesting Facts about 3-(N-(3-amino-2,4,6-triiodo-benzoyl)anilino)propanoic acid

This intriguing compound, known as 3-(N-(3-amino-2,4,6-triiodo-benzoyl)anilino)propanoic acid, is notable for several reasons:

  • Structural complexity: The compound features a unique structure that showcases the interplay between an amino group and a benzoyl moiety, which can impact its chemical behavior and reactivity.
  • Medical relevance: Compounds containing iodine, such as this one, have been studied for their potential applications in medical imaging and therapies, particularly in diagnostics where iodine's high Z number enhances contrast.
  • Trends in halogen chemistry: The presence of multiple iodine atoms contributes to its chemical properties and interactions. Halogenated compounds are often more lipophilic, influencing their biological activity.
  • Synthetic utility: The synthesis of this compound may provide valuable insights into developing new pathways for synthesizing pharmaceuticals, especially those requiring complex functionalities.
  • Potential applications: It is exciting to consider its potential in various fields, including drug development, where modifications to the molecular structure can lead to innovations in targeting specific biological systems.

As chemists continue to explore compounds like this, the potential for uncovering new therapeutic agents and expanding our understanding of chemical interactions remains a captivating area of research. The exploration of such unique compounds is vital in pushing the boundaries of both organic chemistry and medicinal chemistry.

Synonyms
Iobenzamic acid
3115-05-7
Osbil
Acido iobenzamico
Acide iobenzamique
F72UWG2SWK
N-(3-Amino-2,4,6-triiodobenzoyl)-N-phenyl-beta-alanine
DTXSID9057711
.beta.-Alanine, N-(3-amino-2,4,6-triiodobenzoyl)-N-phenyl-
Bilibyk
Osbiland
Razebil
Tracebil
Tracebyl
Isobenzamic acid
Acidum jobenzamicum
ST 5066/S [German]
3-(N-(3-amino-2,4,6-triiodobenzoyl)anilino)propanoic acid
Acide iobenzamique [INN-French]
Acido iobenzamico [INN-Spanish]
Acidum iobenzamicum [INN-Latin]
Acidum iobenzamicum
EINECS 221-484-1
Osbil (TN)
ST-5066
BRN 2180958
N-(3-Amino-2,4,6-triiodobenzoyl)-N-(2-carboxyethyl)aniline
UNII-F72UWG2SWK
IOBENZAMIC ACID [MI]
IOBENZAMIC ACID [INN]
IOBENZAMIC ACID [JAN]
SCHEMBL666698
U-12,031
IOBENZAMIC ACID [USAN]
CHEMBL2106317
DTXCID0031500
IOBENZAMIC ACID [MART.]
CHEBI:31700
IOBENZAMIC ACID [WHO-DD]
FJYJNLIEGUTPIJ-UHFFFAOYSA-N
3-((3-Amino-2,4,6-triiodobenzoyl)phenylamino)propionic acid
Iobenzamic acid (JAN/USAN/INN)
beta-(N-(3-Amino-2,4,6-triiodobenzoyl)phenylamino)propionic acid
beta-ALANINE, N-(3-AMINO-2,4,6-TRIIODOBENZOYL)-N-PHENYL-
Tox21_113974
ST 5066/S
N-(3-Amino-2,4,6-trijodbenzoyl)-N-phenyl-beta-aminopropionsaeure [German]
DB13428
Iobenzamic acid [USAN:INN:BAN:JAN]
NCGC00274272-01
CAS-3115-05-7
NS00010204
D01313
Q6062189
N-(3-Amino-2,4,6-trijodbenzoyl)-N-phenyl-beta-aminopropionsaeure