Skip to main content

3-Nitrobenzamide

ADVERTISEMENT
Identification
Molecular formula
C7H6N2O3
CAS number
644-31-5
IUPAC name
3-nitrobenzamide
State
State
3-Nitrobenzamide is a solid at room temperature, typically forming yellow crystalline structures.
Melting point (Celsius)
178.00
Melting point (Kelvin)
451.15
Boiling point (Celsius)
374.20
Boiling point (Kelvin)
647.35
General information
Molecular weight
166.14g/mol
Molar mass
166.1440g/mol
Density
1.4190g/cm3
Appearence

3-Nitrobenzamide appears as a yellow crystalline powder. This solid compound is stable under normal conditions and exhibits a distinct chemical structure characterized by a nitro group attached to the benzene ring in the meta position relative to the amide group.

Comment on solubility

Solubility of 3-nitrobenzamide

3-nitrobenzamide, with the chemical formula C7H6N2O3, is known for its intriguing solubility characteristics, which can vary significantly under different conditions. Here are some key points to consider:

  • Polar and Non-polar Solvents: 3-nitrobenzamide is generally more soluble in polar solvents due to the presence of the amide group which enhances its interaction with water molecules.
  • Water Solubility: This compound exhibits limited solubility in water, often dissolving to a greater extent in organic solvents such as ethanol or acetone.
  • Temperature Dependence: The solubility of 3-nitrobenzamide can increase with temperature, as is typical for many organic compounds.
  • pH Influence: The pH of the solution can affect solubility; highly acidic or basic conditions may increase dissolution due to ionization of the amide group.

As such, when considering the usage of 3-nitrobenzamide in synthetic processes or applications, it's crucial to take into account the solvent selection and environmental conditions, as these factors significantly dictate its solubility behavior. In practice, the phrase "like dissolves like" is a useful guideline when exploring suitable solvents for dissolving this compound.

Interesting facts

Interesting Facts About 3-Nitrobenzamide

3-Nitrobenzamide is a fascinating compound that finds its significance in both chemical synthesis and biological applications. As a derivative of benzoic acid, it possesses unique properties that make it an interesting subject for study.

Chemical Characteristics

  • Structure: The compound features a nitro group (-NO2) and an amide group (-C(O)NH2) attached to a benzene ring, contributing to its reactivity and interaction with various molecules.
  • Reactivity: The presence of both the nitro and amide functionalities allows for a variety of chemical reactions, including nucleophilic substitutions and coupling reactions.

Applications

  • Pharmaceuticals: 3-Nitrobenzamide has been researched for its potential use in drug formulation, particularly in the development of compounds that target specific biological pathways.
  • Agricultural Chemicals: Its derivatives may play a role in the synthesis of pesticides and other agricultural agents.

Biological Relevance

Research studies suggest that compounds like 3-nitrobenzamide can exhibit varying degrees of bioactivity. For instance:

  • Potential application as an antimicrobial agent.
  • Research suggests it can be used to study enzyme inhibition, providing insights into mechanism-based drug design.

Quote from the Lab

One chemist once remarked, "3-Nitrobenzamide is more than just a molecule; it is a bridge between synthetic chemistry and biological exploration." This emphasizes the compound's dual role in science as both a tool and a subject of inquiry.

In summary, 3-Nitrobenzamide is a prime example of how a simple chemical structure can pave the way for extensive research avenues, showcasing the interconnectedness of chemistry, biology, and pharmacology.

Synonyms
3-Nitrobenzamide
M-NITROBENZAMIDE
Benzamide, 3-nitro-
EINECS 211-431-0
NSC 37327
BRN 0777185
DTXSID5025732
DTXCID605732
4-09-00-01061 (Beilstein Handbook Reference)
3-NITROBENZOIC ACID, AMIDE
211-431-0
kwayepxdghygrw-uhfffaoysa-n
645-09-0
Benzamide, m-nitro-
3-Nitro-benzamide
MFCD00007984
KMU7X7KT5T
CHEMBL338567
NSC-37327
NSC37327
3-nitrophenylcarboxamide
UNII-KMU7X7KT5T
3-Nitrobenzamide, 98%
NITROBENZAMIDE, M-
Oprea1_317236
MLS002415746
SCHEMBL894417
HMS3039O04
Tox21_200090
BDBM50106195
STL071228
AKOS000283200
FN70933
NCGC00091263-01
NCGC00091263-02
NCGC00257644-01
AC-10271
AS-19826
CAS-645-09-0
NCI60_003478
SMR001370909
SY076647
DB-054679
CS-0149880
N0321
NS00035708
EN300-49218
F13605
AE-562/40173655