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Benztropine

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Identification
Molecular formula
C21H25NO
CAS number
86-13-5
IUPAC name
3-[o-tolyl(phenyl)methoxy]-9-azabicyclo[3.3.1]nonane
State
State

At room temperature, benztropine is typically in a solid state. It is often provided as a mesylate salt in pharmaceutical formulations, enhancing its solubility in water.

Melting point (Celsius)
119.00
Melting point (Kelvin)
392.15
Boiling point (Celsius)
498.00
Boiling point (Kelvin)
771.15
General information
Molecular weight
337.45g/mol
Molar mass
337.4520g/mol
Density
1.0950g/cm3
Appearence

Benztropine is a white, crystalline powder that is practically odorless. It is often found as the mesylate salt for increased solubility.

Comment on solubility

Solubility of 3-[o-tolyl(phenyl)methoxy]-9-azabicyclo[3.3.1]nonane

The solubility of 3-[o-tolyl(phenyl)methoxy]-9-azabicyclo[3.3.1]nonane is an intriguing aspect of its chemical behavior. This compound, characterized by its complex bicyclic structure and aromatic components, exhibits solubility that can be influenced by various factors. Here are some key points to consider:

  • Solvent Interaction: The compound is likely to be more soluble in organic solvents such as ethanol, methanol, and dichloromethane due to its hydrophobic aromatic groups.
  • Hydrophobic Nature: The presence of bulky aromatic rings may lead to diminished solubility in water, as hydrophobic interactions prevail.
  • Temperature Dependence: Solubility can also vary with temperature; generally, higher temperatures can increase solubility in organic solvents.
  • pH Influence: As an amine derivative, the solubility may be affected by the pH of the solution—potentially enhancing solubility in basic conditions where protonation may occur.

In conclusion, while this compound may show reduced solubility in polar solvents, its solubility in non-polar and weakly polar solvents is expected to be favorable. These factors contribute significantly to its overall behavior in different environments, making solubility a critical consideration in practical applications.

Interesting facts

Interesting Facts About 3-[o-tolyl(phenyl)methoxy]-9-azabicyclo[3.3.1]nonane

This compound belongs to a unique class of chemical compounds that feature an intricate bicyclic structure, which lends it intriguing properties and potential applications. Here are some interesting facts about this fascinating molecule:

  • Bicyclic Framework: The bicyclic nature of this compound indicates that it contains two interconnected rings, a characteristic that often influences its reactivity and stability. Such structures are frequently found in natural products, providing a bridge between synthetic and naturally occurring compounds.
  • Functionalized Aromatics: The presence of both o-tolyl and phenyl groups contributes to the compound's electronic and steric properties, making it an attractive candidate for various chemical reactions. These aromatic rings can enhance lipophilicity, affecting how the compound interacts with biological systems.
  • Synthesis Versatility: The combination of a bicyclic system with aromatic constituents allows for a variety of synthetic approaches. Chemists often explore these mixed systems to develop new methodologies for constructing complex organic molecules.
  • Pharmacological Potential: Compounds with similar structural motifs have been investigated for their potential biological activities. They could serve as leads in drug discovery, particularly in targeting specific receptors or biological pathways.
  • Chirality: The asymmetric centers present in this compound contribute to its chirality, which is paramount in determining biological activity. Understanding how different enantiomers affect biological pathways can lead to significant advancements in medicinal chemistry.

As a scientist or a chemistry student, examining such complex compounds can reveal not just their structural versatility but also their potential in developing novel chemical entities that could lead to breakthroughs across various disciplines, from pharmacology to materials science. Exploring the synthesis and reactivity of this compound can provide valuable insights into the principles of organic chemistry.

Synonyms
KSD 2416
6606-03-7
BRN 1547600
Norgranatanol-3-alpha-(2-methylbenzhydryl)aether [German]
3-alpha-(o-Methyldiphenylmethoxy)-9-azabicyclo(3.3.1)-nonane
9-AZABICYCLO(3.3.1)NONANE, 3-alpha-(o-METHYLDIPHENYLMETHOXY)-
Norgranatanol-3-alpha-(2-methylbenzhydryl)aether
DTXSID00984533
3-[(2-Methylphenyl)(phenyl)methoxy]-9-azabicyclo[3.3.1]nonane