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3-oxo-N-(2-pyridyl)-3-(3,4,5-trimethoxyphenyl)propanamide

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Identification
Molecular formula
C17H18N2O5
CAS number
72257-87-7
IUPAC name
3-oxo-N-(2-pyridyl)-3-(3,4,5-trimethoxyphenyl)propanamide
State
State

This compound is in a solid state at room temperature.

Melting point (Celsius)
158.00
Melting point (Kelvin)
431.20
Boiling point (Celsius)
515.30
Boiling point (Kelvin)
788.50
General information
Molecular weight
328.34g/mol
Molar mass
328.3440g/mol
Density
1.2325g/cm3
Appearence

3-oxo-N-(2-pyridyl)-3-(3,4,5-trimethoxyphenyl)propanamide typically appears as a crystalline powder.

Comment on solubility

Solubility Insights for 3-oxo-N-(2-pyridyl)-3-(3,4,5-trimethoxyphenyl)propanamide

The solubility of 3-oxo-N-(2-pyridyl)-3-(3,4,5-trimethoxyphenyl)propanamide can be quite complex owing to its intricate structure. Various factors play a crucial role in determining its solubility behaviors:

  • Polarity: The presence of functional groups such as the amide and pyridine rings suggests varying polarities which can influence the solubility in different solvents.
  • Solvent Interaction: It is likely to be more soluble in polar organic solvents like methanol or dimethyl sulfoxide due to the ability of these solvents to stabilize the charged or polar regions of the molecule.
  • Temperature: Typically, increasing temperature enhances solubility; hence experiments at elevated temperatures may lead to better solubility outcomes for this compound.
  • Hydrogen Bonding: The molecule's capability for hydrogen bonding will also significantly impact its solubility, especially in water, despite the hydrophobic trimethoxyphenyl groups counterbalancing this effect.

In summary, while 3-oxo-N-(2-pyridyl)-3-(3,4,5-trimethoxyphenyl)propanamide may exhibit reasonable solubility in selected organic solvents, its overall solubility profile is reflective of the delicate balance between its polar and non-polar characteristics and the solvent's nature. To maximize solubility, careful selection of solvent and conditions is crucial for practical applications.

Interesting facts

Interesting Facts about 3-oxo-N-(2-pyridyl)-3-(3,4,5-trimethoxyphenyl)propanamide

This fascinating compound, known as 3-oxo-N-(2-pyridyl)-3-(3,4,5-trimethoxyphenyl)propanamide, captures the interest of many chemists due to its unique structural features and potential applications. Here are some key points to consider:

  • Diverse Functional Groups: The compound contains both an amide and a ketone group, which are crucial in organic chemistry for their reactivity and the role they play in biological systems.
  • Pyridine Ring: The presence of the pyridine moiety contributes to the compound's properties, often enhancing its solubility and biological activity. Pyridine derivatives are known for their use in pharmaceuticals.
  • Trimethoxyphenyl Substituent: The 3,4,5-trimethoxyphenyl group indicates a high degree of *substitutivity*, which can lead to interesting electronic and steric interactions in chemical reactions.
  • Biological Significance: Compounds similar to this one are often explored for their potential antifungal and antibacterial properties. The design of such compounds can lead to the development of new therapeutic agents.
  • Synthetic Pathways: The synthesis of this compound can illustrate various organic reactions, such as acylation and coupling reactions, making it an appealing target for chemistry students and researchers alike.
  • Applications in Research: This compound's unique structure may serve as a lead compound in drug discovery, particularly in the fields of cancer and neurodegenerative diseases.

The study of 3-oxo-N-(2-pyridyl)-3-(3,4,5-trimethoxyphenyl)propanamide is a perfect example of how synthetic chemistry not only leads to new compounds but also expands our understanding of their potential roles in *biochemistry* and *pharmacology*. As noted by many researchers, "The beauty of chemistry lies in its endless possibilities to create and innovate."

Synonyms
ACETAMIDE, N-2-PYRIDYL-2-(3,4,5-TRIMETHOXYBENZOYL)-
23771-21-3
N-2-Pyridyl-2-(3,4,5-trimethoxybenzoyl)-acetamide
DTXSID80178438
RefChem:315538
DTXCID10100929