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3-oxo-N-(p-tolyl)butanamide

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Identification
Molecular formula
C11H13NO2
CAS number
3937-56-6
IUPAC name
3-oxo-N-(p-tolyl)butanamide
State
State

At room temperature, 3-oxo-N-(p-tolyl)butanamide is typically a solid, existing in a stable crystalline form. Its stability and solid-state make it easy to handle in laboratory environments, and it does not evaporate like a liquid or disperse as a gas at standard conditions.

Melting point (Celsius)
93.40
Melting point (Kelvin)
366.55
Boiling point (Celsius)
298.20
Boiling point (Kelvin)
571.35
General information
Molecular weight
191.24g/mol
Molar mass
191.2370g/mol
Density
1.0670g/cm3
Appearence

3-oxo-N-(p-tolyl)butanamide typically appears as a white or off-white crystalline solid. Its crystallinity can affect its texture and sheen, often dissolving to a fine powder. Upon closer inspection, the solid may have a subdued shine under light due to its crystalline nature.

Comment on solubility

Solubility of 3-oxo-N-(p-tolyl)butanamide

3-oxo-N-(p-tolyl)butanamide is a compound that demonstrates relatively low solubility in water due to its structural features. The solubility of a compound is often influenced by the following key factors:

  • Polarity: The presence of functional groups and the overall molecular polarity play a significant role in determining solubility. In this compound, the amide group contributes some polar characteristics, but the bulky p-tolyl group introduces hydrophobic properties, reducing water solubility.
  • Hydrogen bonding: The ability of a molecule to form hydrogen bonds can enhance solubility in polar solvents. While 3-oxo-N-(p-tolyl)butanamide can engage in hydrogen bonding through its carbonyl and amide functionalities, the limited electron-donating capacity of the p-tolyl group may hinder efficient interactions with water molecules.
  • Temperature: Solubility can vary with temperature. Increasing the temperature can sometimes improve the solubility of organic compounds; however, specific data for this compound at various temperatures would be required to make definitive claims.

In practical terms, 3-oxo-N-(p-tolyl)butanamide is more likely to dissolve in organic solvents such as ethanol or methanol rather than in water. When working with this compound, it is essential to consider its solubility characteristics to ensure effective application in chemical processes or formulations.

Interesting facts

Interesting Facts about 3-oxo-N-(p-tolyl)butanamide

3-oxo-N-(p-tolyl)butanamide, a compound belonging to the class of amides, presents a fascinating array of characteristics and applications that intrigue both chemists and researchers alike. Here are some engaging insights:

  • Versatile Applications: This compound is significant in organic synthesis and medicinal chemistry. It can serve as an intermediate in the synthesis of various pharmaceuticals, owing to its amide structure which is commonly found in many bioactive molecules.
  • Structural Insights: The presence of the p-tolyl group adds unique properties to the molecule. This aromatic substituent not only enhances stability but also influences the compound's reactivity and interaction with biological targets.
  • Chemical Behavior: The ketone functionality (the 3-oxo part) in this compound is crucial in enabling a variety of reactions, such as nucleophilic addition and condensation reactions, making it an important building block in synthetic organic chemistry.
  • Biological Significance: Compounds like 3-oxo-N-(p-tolyl)butanamide are studied for their potential biological activities, including anti-inflammatory, analgesic, and anticancer properties. Understanding the pharmacophore associated with this compound can lead to new drug discoveries.
  • Research Opportunities: Given its molecular structure, there is ample opportunity for research into modifications and analogs of 3-oxo-N-(p-tolyl)butanamide, which may yield compounds with enhanced efficacy or reduced side effects.

In conclusion, 3-oxo-N-(p-tolyl)butanamide is not only a key player in organic synthesis but also a promising candidate in pharmaceutical research. The interplay of its structural features opens up numerous possibilities for innovative applications in various scientific fields.

Synonyms
2415-85-2
N-(4-Methylphenyl)-3-oxobutanamide
Butanamide, N-(4-methylphenyl)-3-oxo-
Acetoacet-p-toluidide
p-Methylacetoacetanilide
4'-Methylacetoacetanilide
N-Acetoacetyl-p-toluidine
p-Acetoacetotoluidide
4-Methylacetoacetanilide
4-Acetoacetylaminotoluene
ACETOACETIC ACID P-TOLUIDIDE
NSC 50631
CCRIS 7751
EINECS 219-327-7
NSC-50631
DTXSID5062394
G147166Y69
ACETOACETYL-P-TOLUIDINE, N-
N-(4-METHYLPHENYL)ACETYLACETAMIDE
N-(P-METHYLPHENYL)-2-ACETYLACETAMIDE
1-(4-METHYLPHENYLAMINO)BUTA-1,3-DIONE
p-Acetoacetotoluidide (8CI)
DTXCID6037013
219-327-7
3-Oxo-N-(p-tolyl)butanamide
UNII-G147166Y69
MFCD00043931
SCHEMBL56594
N-Acetoacetyl-4-methylaniline
ALBB-023409
NSC50631
STK400316
N-(4-methylphenyl)-3-oxobutan-amide
AKOS000313212
DB-046364
A1021
CS-0153054
NS00027570
EN300-01460
E75887
10D-069
SR-01000389576
SR-01000389576-1
Q27278516