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Selective Estrogen Receptor Modulator (SERM)

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Identification
Molecular formula
C28H30N2O
CAS number
1334534-38-4
IUPAC name
3-phenyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1H-indole
State
State

The compound is a solid at room temperature and is generally stable under standard laboratory conditions. It does not evaporate easily and is handled as a dry powder.

Melting point (Celsius)
172.00
Melting point (Kelvin)
445.15
Boiling point (Celsius)
619.30
Boiling point (Kelvin)
892.50
General information
Molecular weight
425.56g/mol
Molar mass
425.5560g/mol
Density
1.2200g/cm3
Appearence

This compound is typically a solid at room temperature, appearing as a crystalline powder. The color may vary from white to off-white based on the specific impurities or form of crystallization.

Comment on solubility

Solubility Overview of 3-phenyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1H-indole

The solubility of 3-phenyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1H-indole can be intricate due to its complex structure. Understanding its solubility behavior is vital for various applications, especially in medicinal chemistry.

Key Factors Influencing Solubility

Several factors can affect the solubility of this compound:

  • Functional Groups: The presence of both indole and pyrrolidine moieties can influence solubility by affecting polarity and hydrogen bonding capabilities.
  • Solvent Polarity: This compound may exhibit varied solubility in polar versus nonpolar solvents, potentially being more soluble in organic solvents like DMSO or ethanol.
  • pH Levels: For compounds containing basic or acidic functional groups, alterations in pH can drastically change their solubility. This is particularly relevant for the pyrrolidinyl group.

General Observations

While specific solubility data may not be readily available, one could propose that:

  • The compound may be moderately soluble in organic solvents.
  • It may show limited solubility in water due to its hydrophobic regions, particularly those derived from the phenyl and indole moieties.

In conclusion, the solubility of 3-phenyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1H-indole is likely nuanced and dependent on several factors related to its chemical structure and the environment in which it is placed. As with many organic compounds, experimentation may be required for accurate solubility determination in targeted conditions.

Interesting facts

Interesting Facts about 3-phenyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1H-indole

This complex organic compound belongs to a class of chemical molecules known for their diverse applications in medicinal chemistry and pharmacology. Here are some engaging insights into this intriguing compound:

  • Structural Complexity: The structure of this compound features a core indole structure fused with a phenyl group and an ethoxy-substituted phenyl moiety. This intricate design is crucial for its biological activity and interaction with various receptors.
  • Pharmacological Potential: Compounds like this one are being studied for their potential as therapeutic agents. They may exhibit properties such as anti-inflammatory, analgesic, or even neuroprotective effects, making them a subject of interest in drug development.
  • Role of Pyrrolidine: The presence of the pyrrolidine ring in the structure can enhance the compound's binding affinity to biological targets. Pyrrolidine derivatives are often found in drugs that act on the central nervous system, highlighting the importance of such functional groups in medicinal chemistry.
  • Research Highlights: Recent studies have explored the synthesis and characterization of similar indole derivatives, aiming to modify their properties to improve efficacy and reduce side effects. This compound stands as a testament to the innovative approaches taken by chemists in tailoring compounds for specific biological functions.

As research on compounds like 3-phenyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1H-indole continues, scientists are excited about the potential breakthroughs that could arise from understanding its mechanism of action and developing new therapeutic strategies.

Synonyms
7720-63-0
INDOLE, 3-PHENYL-2-(p-(2-(1-PYRROLIDINYL)ETHOXY)PHENYL)-
3-Phenyl-2-p-(beta-pyrrolidinoethoxy)phenylindole
2-(p-(beta-Pyrrolidinoethoxy)phenyl)-3-phenylindole
DTXSID40227956