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Fluoxetine

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Identification
Molecular formula
C17H18F3NO
CAS number
54910-89-3
IUPAC name
3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine
State
State

At room temperature, fluoxetine is in a solid state.

Melting point (Celsius)
179.00
Melting point (Kelvin)
452.15
Boiling point (Celsius)
180.00
Boiling point (Kelvin)
453.15
General information
Molecular weight
309.33g/mol
Molar mass
309.3310g/mol
Density
1.1670g/cm3
Appearence

Fluoxetine is a white to off-white crystalline solid. It often appears in the form of a fine powder.

Comment on solubility

Solubility of 3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine

The compound 3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, with the chemical formula C17H18F3NO, exhibits notable solubility characteristics that are influenced by its unique molecular structure. Understanding its solubility is crucial for its applications in various chemical processes.

Key Insights on Solubility:

  • Polarity: The presence of the trifluoromethyl group contributes to the compound's polar characteristics, thus affecting its interaction with solvents.
  • Solvent Compatibility: This compound may dissolve well in organic solvents such as ethyl acetate or dimethyl sulfoxide (DMSO), but it is likely to have limited solubility in water due to its hydrophobic aromatic rings.
  • Temperature Dependency: Solubility often varies with temperature; increased temperatures may enhance the solubility of this compound in organic solvents.
  • Hydrogen Bonding: The amine functional group can engage in hydrogen bonding, potentially enhancing solubility in polar solvents under specific conditions.

In summary, while the solubility of 3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine can vary widely depending on the solvent and environmental conditions, its overall behavior demonstrates the intriguing interplay of polarity, functional groups, and solvent interactions. Each of these factors plays a pivotal role in determining how this compound behaves in solution.

Interesting facts

Interesting Facts about 3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine

The compound 3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, often abbreviated as a longer name due to its complexity, is a fascinating molecule primarily known for its prominent role in pharmaceutical and chemical research. Here are some compelling insights about this intriguing compound:

  • Structure and Functionality: This compound features a unique structure with a trifluoromethyl group, which is recognized for enhancing the lipophilicity and metabolic stability of the molecule. This characteristic is essential in drug development.
  • Biological Activity: Compounds with phenoxy and amine groups often exhibit a variety of biological activities, including antihypertensive and antipsychotic properties. The presence of the trifluoromethyl group can significantly influence the interaction with biological targets.
  • Fluorinated Compounds: The incorporation of fluorine atoms in organic molecules can lead to significant changes in their chemical properties. This is why trifluoromethyl groups are often referred to as "magic groups" in medicinal chemistry, allowing modifications that can drastically alter a compound's behavior.
  • Research Potential: Scientists continue to explore compounds like this for their potential use in treatments for various conditions, including cancer and neurological disorders, making it a compound of interest in medicinal chemistry and drug design.

In summary, 3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine is not just a simple organic compound; its intricate structure and functionality place it at the forefront of chemical and pharmaceutical research. As quoted in the field, "The future of drug design lies in understanding and manipulating small molecules," illustrating the potential impact of compounds like this in developing new therapies.

Synonyms
Norfluoxetine
83891-03-6
Desmethylfluoxetine
56161-73-0
3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine
3-Phenyl-3-(4-trifluoromethyl-phenoxy)-propylamine
3-phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine
UNII-K8D70XE2F4
K8D70XE2F4
gamma-(4-(Trifluoromethyl)phenoxy)benzenepropanamine
Norfluoxetin
DTXSID80866540
(+/-)-DESMETHYLFLUOXETINE
C16H16F3NO
Benzenepropanamine, gamma-(4-(trifluoromethyl)phenoxy)-
(Phenyl-d5)
BENZENEPROPANAMINE, .GAMMA.-(4-(TRIFLUOROMETHYL)PHENOXY)-, (+/-)-
(R)-3-Phenyl-3-(4-trifluoromethyl-phenoxy)-propylamine
benzenepropanamine, gamma-[4-(trifluoromethyl)phenoxy]-
(S)-3-PHENYL-3-(4-TRIFLUOROMETHYL-PHENOXY)-PROPYLAMINE
(R)-Norfluoxetine-d5 (Phenyl-d5)
Benzenepropanamine, gamma-[4-(trifluoromethyl)phenoxy]-, (+/-)-
BENZENEPROPANAMINE, GAMMA-(4-(TRIFLUOROMETHYL)PHENOXY)-, (+/-)-
Benzenepropanamine, g-[4-(trifluoromethyl)phenoxy]-
CHEMBL1494
GTPL208
SCHEMBL686500
DTXCID50199978
CHEBI:180876
BCP20944
SYB64864
BDBM50180661
NSC675448
AKOS015911091
Norfluoxetine hcl;N-desmethylfluoxetine
NSC-675448
SB32578
SB32682
SB38941
DB-262477
HY-135556
CS-0113461
NS00008908
3-(4-trifluoromethylphenoxy)-3-phenylproplyamine
L001023
Q7452012
3-phenyl-3-[4-(triluoromethyl)phenoxy]propan-1-amine
BRD-A79769222-001-01-3
3-phenyl-3[4'-trifluoromethyl-phenoxy]-propan-1-amine
3-Phenyl-3-[4-(trifluoromethyl)phenoxy]-1-propanamine #
Benzenepropanamine, .gamma.-[4-(trifluoromethyl)phenoxy]-