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3-phenyl-5-[2-(1-piperidyl)ethyl]isoxazole

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Identification
Molecular formula
C18H22N2O
CAS number
22043-91-0
IUPAC name
3-phenyl-5-[2-(1-piperidyl)ethyl]isoxazole
State
State

The compound is a solid at room temperature. It is often utilized in the form of a powder for various applications in chemical and pharmaceutical research.

Melting point (Celsius)
106.00
Melting point (Kelvin)
379.15
Boiling point (Celsius)
357.50
Boiling point (Kelvin)
630.65
General information
Molecular weight
282.37g/mol
Molar mass
340.4490g/mol
Density
1.1900g/cm3
Appearence

The compound is typically a crystalline solid. It appears as a white to off-white powder at room temperature. This appearance aligns with the characteristics of most organic compounds that possess both aromatic and heterocyclic structures.

Comment on solubility

Solubility of 3-phenyl-5-[2-(1-piperidyl)ethyl]isoxazole

The solubility of 3-phenyl-5-[2-(1-piperidyl)ethyl]isoxazole presents an interesting case, particularly due to its complex organic structure. Solubility in various solvents can often be attributed to factors such as molecular polarity, hydrogen bonding potential, and the overall structural characteristics of the compound.

Key aspects of its solubility include:

  • Polar Proximity: The presence of the piperidyl group suggests potential interactions with polar solvents, enhancing solubility in such environments.
  • Hydrophobic Phenyl Ring: The phenyl group, being hydrophobic, may lead to lower solubility in water, indicating that organic solvents could be more suitable for dissolution.
  • Temperature Dependence: Like many organic compounds, solubility may increase with temperature, allowing for greater interaction with solvents.

In conclusion, while 3-phenyl-5-[2-(1-piperidyl)ethyl]isoxazole may exhibit limited solubility in aqueous solutions, its solubility profile in organic solvents is likely to be more favorable, making it important to consider solvent choice in experimental setups.

Interesting facts

Exploring 3-phenyl-5-[2-(1-piperidyl)ethyl]isoxazole

This compound, known as 3-phenyl-5-[2-(1-piperidyl)ethyl]isoxazole, belongs to an interesting class of organic compounds called isoxazoles. Isoxazoles are characterized by a five-membered ring containing both nitrogen and oxygen, which gives them unique chemical properties and biological activities.

Key Characteristics:

  • Versatile Chemical Structure: The presence of the isoxazole ring along with a phenyl and piperidyl group enhances the compound's ability to interact with various biological targets. This versatility opens avenues for further medicinal chemistry explorations.
  • Potential Pharmacological Applications: Compounds such as this one have garnered interest in pharmacology for their potential in treating neurological disorders. Their structure allows them to interact with neuronal receptors, possibly leading to therapeutic effects.
  • Functionalization: The unique structure makes it a potential candidate for further derivatization. Chemists can modify the molecule to study structure-activity relationships, potentially leading to the development of new pharmaceuticals.

The compound's piperidine moiety introduces a cyclic amine, which is known for its ability to enhance solubility and interaction with biological membranes. As a result, compounds featuring piperidine derivatives often exhibit better bioavailability and efficacy in laboratory settings.

Future Directions:

Research on 3-phenyl-5-[2-(1-piperidyl)ethyl]isoxazole is still ongoing, and here are some exciting potential avenues of investigation:

  • Exploration of its neuroprotective properties.
  • Investigating its potential as an antidepressant or anxiolytic agent.
  • Development of analogs to enhance potency and selectivity.

As is often said in scientific circles, “The journey of discovery begins with one molecule.” 3-phenyl-5-[2-(1-piperidyl)ethyl]isoxazole exemplifies this notion, bringing with it not just a rich tapestry of chemical and biological intrigue, but also the potential for significant advancements in medicinal chemistry.

Synonyms
58446-07-4
3-PHENYL-5-(2-PIPERIDIN-1-YLETHYL)ISOXAZOLE
3-Phenyl-5-(2-(piperidin-1-yl)ethyl)isoxazole
3-phenyl-5-(2-piperidin-1-ylethyl)-1,2-oxazole