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3-phenylazetidin-2-one

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Identification
Molecular formula
C9H9NO
CAS number
5030-92-8
IUPAC name
3-phenylazetidin-2-one
State
State

At room temperature, 3-phenylazetidin-2-one is typically in a solid state.

Melting point (Celsius)
112.00
Melting point (Kelvin)
385.15
Boiling point (Celsius)
260.00
Boiling point (Kelvin)
533.15
General information
Molecular weight
147.18g/mol
Molar mass
147.1790g/mol
Density
1.2000g/cm3
Appearence

3-Phenylazetidin-2-one typically appears as a solid crystalline substance. Its appearance can vary from white to off-white, depending on the specific sample and any impurities present. This compound may be provided in the form of a powder or small crystalline chunks.

Comment on solubility

Solubility of 3-phenylazetidin-2-one

The solubility of 3-phenylazetidin-2-one, a compound belonging to the class of azetidinones, exhibits some intriguing characteristics. Understanding its solubility behavior is crucial for both practical applications and theoretical studies.

Solubility Characteristics:

  • Solvent Preferences: 3-phenylazetidin-2-one is generally more soluble in organic solvents such as ethanol, methanol, and other polar aprotic solvents.
  • Water Solubility: The compound has limited solubility in water due to the hydrophobic nature of the phenyl group attached to the azetidinone ring.
  • Impact of Temperature: As with many organic compounds, the solubility of 3-phenylazetidin-2-one can increase with temperature, contributing to a more pronounced solubility in hot organic solvents.

In summary, while 3-phenylazetidin-2-one shows reasonable solubility in specific organic solvents, its hydrophobic properties limit its interaction with water. To quote an important principle of solubility: "like dissolves like." Thus, the compound favors interactions with other non-polar or slightly polar substances while remaining relatively insoluble in polar solvents like water.

Interesting facts

Exploring 3-Phenylazetidin-2-One

3-Phenylazetidin-2-one is an intriguing chemical compound that belongs to a class of compounds known as azetidines. It features a four-membered ring structure, which gives rise to various interesting properties and reactivity patterns. Here are some notable facts that highlight the significance and applications of this compound:

  • Cyclic Structure: The azetidine ring in 3-phenylazetidin-2-one is known for its unique strain and reactivity, making it a valuable motif in synthetic organic chemistry.
  • Biological Activity: Compounds containing azetidine rings, including 3-phenylazetidin-2-one, have been studied for their potential pharmacological properties, including antibacterial and antifungal activities.
  • Synthesis Versatility: One of the appealing aspects of 3-phenylazetidin-2-one is its synthetic accessibility. Various methods exist for its synthesis, including ring-closing reactions and coupling techniques that allow chemists to create diverse derivatives.
  • Applications in Drug Design: The structural features of 3-phenylazetidin-2-one make it a candidate in drug discovery. The rigidity of the azetidine ring can contribute to the potency and specificity of bioactive molecules.
  • Versatile Intermediate: It can serve as an important intermediate in the synthesis of more complex organic compounds, showcasing its role in the broader context of chemical synthesis.

In summary, 3-phenylazetidin-2-one is not just a simple compound; its unique structure, potential biological activities, and versatility in chemical synthesis make it a compelling subject for further exploration in both academic research and pharmaceutical development. As we continue to study its properties, we may uncover new applications and pave the way for innovative therapeutic agents.

Synonyms
3-phenylazetidin-2-one
3-Phenyl-2-azetidinone
17197-57-8
3-Fenil-2-azetidinone
2-AZETIDINONE, 3-PHENYL-
L 1759
3-Fenil-2-azetidinone [Italian]
NSC 173143
BRN 0120633
2-Azetidinone,3-phenyl-
5-21-08-00053 (Beilstein Handbook Reference)
SCHEMBL1828312
SCHEMBL14515493
NSC173143
STL300227
AKOS006274423
NSC-173143
DS-012967