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3-(Pyrrolidin-1-ylmethyl)-1H-indole

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Identification
Molecular formula
C13H16N2
CAS number
5118-13-8
IUPAC name
3-(pyrrolidin-1-ylmethyl)-1H-indole
State
State

Under standard conditions of temperature and pressure (25°C and 1 atm), 3-(Pyrrolidin-1-ylmethyl)-1H-indole is generally solid. However, it can transition to other states depending on temperature, being a solid at temperatures below its melting point.

Melting point (Celsius)
70.00
Melting point (Kelvin)
343.15
Boiling point (Celsius)
421.00
Boiling point (Kelvin)
694.15
General information
Molecular weight
198.29g/mol
Molar mass
198.2730g/mol
Density
1.1526g/cm3
Appearence

3-(Pyrrolidin-1-ylmethyl)-1H-indole is a pale yellow to light brown crystalline solid. It may appear as a powder or fine crystals and can have a characteristic odor. The compound's color and form may depend on purity and specific conditions of its synthesis.

Comment on solubility

Solubility of 3-(pyrrolidin-1-ylmethyl)-1H-indole

The solubility of 3-(pyrrolidin-1-ylmethyl)-1H-indole can be characterized by several key aspects:

  • Polar Nature: Due to the presence of the pyrrolidin moiety, this compound exhibits some polar characteristics, potentially enhancing its solubility in polar solvents.
  • Solvent Compatibility: It is generally expected to have good solubility in commonly used organic solvents like dimethyl sulfoxide (DMSO), ethanol, and methanol, while being less soluble in non-polar solvents.
  • Hydrogen Bonding: The ability to form hydrogen bonds can increase solubility in certain environments and can be significantly affected by the solvent's nature.

In summary, the solubility of 3-(pyrrolidin-1-ylmethyl)-1H-indole is influenced by its molecular structure, polar contributions from the pyrrolidine ring, as well as the solvent used. For optimal applications, it is advisable to perform empirical solubility tests in specific conditions to determine the exact dissolution behavior of this compound.

Interesting facts

Interesting Facts about 3-(pyrrolidin-1-ylmethyl)-1H-indole

3-(pyrrolidin-1-ylmethyl)-1H-indole is a fascinating compound with unique structural features and diverse applications in medicinal chemistry. Here are some key points that highlight its significance:

  • Structural Biochemistry: This compound contains both an indole ring and a pyrrolidine moiety. The indole structure is prevalent in various natural alkaloids and plays a crucial role in numerous biochemical processes, including neurotransmission.

  • Biological Activity: Compounds containing the indole ring are often found in medicinal agents. Research suggests that 3-(pyrrolidin-1-ylmethyl)-1H-indole may exhibit properties related to neuroactivity, making it a potential candidate for further pharmacological studies.

  • Cheminformatics: The unique 3D conformation of 3-(pyrrolidin-1-ylmethyl)-1H-indole allows researchers to explore its interaction with various biological targets. This characteristic makes it a valuable tool for drug design and discovery.

  • Research Implications: The structural and functional complexity raises interesting questions for scientists. As one researcher noted, “The ability to modify the pyrrolidine group opens avenues for creating derivatives with enhanced biological profiles.”

  • Synthesis Insights: The synthesis of this compound can involve various methods, including those employing novel coupling reactions. This provides students with practical experience in synthetic organic chemistry techniques.

In summary, 3-(pyrrolidin-1-ylmethyl)-1H-indole is not just a chemical entity; it represents a rich area of exploration within the realms of pharmacology, organic synthesis, and molecular design. Its integration into research can lead to significant advancements in the understanding of drug mechanisms and the development of therapeutic agents.

Synonyms
5379-94-2
3-(pyrrolidin-1-ylmethyl)-1H-indole
3-(PYRROLIDIN-1-YLMETHYL)INDOLE
1H-INDOLE, 3-(1-PYRROLIDINYLMETHYL)-
3-(1-Pyrrolidinylmethyl)indole
N-Skatylpyrrolidine
3-[(pyrrolidin-1-yl)methyl]-1H-indole
3-Pyrrolidinomethyl indole
BRN 0477183
AI3-60053
NSC24945
Oprea1_757961
Oprea1_802988
5-22-10-00028 (Beilstein Handbook Reference)
SCHEMBL10463380
DTXSID50202072
MFCD00450050
NSC 24945
NSC-24945
AKOS000291488
DB-071742
SR-01000318032
SR-01000318032-1
Z131583576