Skip to main content

3-(trifluoromethyl)-5,6,7,8,9,10-hexahydrocyclohepta[b]quinolin-11-one

ADVERTISEMENT
Identification
Molecular formula
C14H12F3NO
CAS number
10549-75-0
IUPAC name
3-(trifluoromethyl)-5,6,7,8,9,10-hexahydrocyclohepta[b]quinolin-11-one
State
State
The compound is typically encountered as a solid at room temperature.
Melting point (Celsius)
89.00
Melting point (Kelvin)
362.15
Boiling point (Celsius)
367.00
Boiling point (Kelvin)
640.15
General information
Molecular weight
271.26g/mol
Molar mass
271.2630g/mol
Density
1.3280g/cm3
Appearence

The compound appears as a colorless to off-white crystalline solid. It is typically provided as a powder or crystalline mass.

Comment on solubility

Solubility of 3-(trifluoromethyl)-5,6,7,8,9,10-hexahydrocyclohepta[b]quinolin-11-one

When evaluating the solubility of 3-(trifluoromethyl)-5,6,7,8,9,10-hexahydrocyclohepta[b]quinolin-11-one, several factors come into play. The presence of the trifluoromethyl group can significantly influence the compound's solubility characteristics due to its electronegativity and steric effects. Here are some key considerations:

  • Polarity: The trifluoromethyl group introduces a degree of polarity, which can enhance solubility in polar solvents such as water, while potentially reducing solubility in non-polar solvents.
  • Hydrophobic regions: The hexahydrocyclohepta structure, with its multiple ring systems, may exhibit hydrophobic interactions that can limit solubility in polar environments.
  • Solvent choices: Due to its unique structure, the compound might demonstrate variable solubility across different solvents, illustrating that various organic solvents or mixtures might be more appropriate for dissolution.

In summary, while the presence of the trifluoromethyl group suggests potential solubility in polar solvents, the hydrophobic aspects of the molecule must be carefully considered, leading to a nuanced understanding of its overall solubility profile. For practical applications, it is advised to conduct empirical solubility tests across different solvents to accurately characterize its behavior.

Interesting facts

Interesting Facts about 3-(trifluoromethyl)-5,6,7,8,9,10-hexahydrocyclohepta[b]quinolin-11-one

This compound, known for its complex cyclic structure, belongs to a class of organic compounds that exhibit a rich array of chemical properties and biological activities. It features a striking trifluoromethyl group, which contributes significantly to its reactivity and hydrophobic character. Here are some fascinating insights into this intriguing compound:

  • Biological Potential: Compounds with similar structures have been researched for their potential pharmacological effects, including anti-inflammatory and anticancer properties. It opens avenues for further exploration in medicinal chemistry.
  • Fluorination Importance: The trifluoromethyl group is notable for introducing lipophilicity, enhancing the ability of molecules to permeate cellular membranes, which is a key consideration in drug design.
  • Synthetic Challenges: The synthesis of such a complex bicyclic structure can pose significant challenges due to the multiple stereocenters and ring junctions, often requiring advanced synthetic methodologies.
  • Applications in Material Science: Beyond medicinal applications, this compound may find uses in developing advanced materials, perhaps exploring its electronegative properties for electronic applications.
  • Research Opportunities: The unique combination of cyclic and aromatic features makes it a valuable target for research in organic chemistry, particularly in studying reaction mechanisms and tropane-like derivatives.

In summary, 3-(trifluoromethyl)-5,6,7,8,9,10-hexahydrocyclohepta[b]quinolin-11-one is not merely a chemical compound; it is a potential gateway into new scientific discoveries. With ongoing research, its myriad applications across various fields may soon be unveiled, making it a compound to watch in the evolving landscape of chemistry.

Synonyms
BRN 1481624
11H-CYCLOHEPTA(b)QUINOLIN-11-ONE, 5,6,7,8,9,10-HEXAHYDRO-3-(TRIFLUOROMETHYL)-
18819-25-5
DTXSID90172164
5-21-08-00535 (Beilstein Handbook Reference)
5,6,7,8,9,10-Hexahydro-3-(trifluoromethyl)-11H-cyclohepta(b)quinolin-11-one
DTXCID0094655
CHEMBL1802880
WTAYGPWOLMJSHX-UHFFFAOYSA-N