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3-(Trifluoromethyl)phenol

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Identification
Molecular formula
C7H5F3O
CAS number
98-17-9
IUPAC name
3-(trifluoromethyl)phenol
State
State

At room temperature, 3-(Trifluoromethyl)phenol is a solid. The compound may sometimes appear as an oily liquid depending on the exact room conditions.

Melting point (Celsius)
31.00
Melting point (Kelvin)
304.15
Boiling point (Celsius)
174.00
Boiling point (Kelvin)
447.15
General information
Molecular weight
160.13g/mol
Molar mass
160.1270g/mol
Density
1.3900g/cm3
Appearence

3-(Trifluoromethyl)phenol appears as a colorless to pale yellow liquid or solid. The compound may exhibit a moderate degree of crystallinity, dependent on its environmental conditions. It can have a mildly aromatic odor resembling that of phenolic compounds.

Comment on solubility

Solubility of 3-(trifluoromethyl)phenol

3-(trifluoromethyl)phenol, a derivative of phenolic compounds, exhibits unique solubility characteristics due to the influence of its trifluoromethyl group.

In general, the solubility of 3-(trifluoromethyl)phenol can be summarized as follows:

  • Solvent Effects: It shows a higher solubility in organic solvents such as ethanol and acetone compared to water.
  • Water Solubility: The presence of the bulky, electronegative trifluoromethyl group reduces its overall polarity, resulting in low solubility in water.
  • Temperature Impact: Increasing temperature may enhance solubility slightly but does not change its general low aqueous solubility.

As with many organic compounds containing fluorinated groups, their solubility properties can be quite distinct. Thus, it is often observed that:

  1. Fluorinated compounds like 3-(trifluoromethyl)phenol are less soluble in polar solvents.
  2. They demonstrate improved solubility in non-polar or weakly polar solvents.

In conclusion, understanding the solubility of 3-(trifluoromethyl)phenol is crucial for applications in synthesis and chemical reactions, reinforcing the adage that “the solubility of a compound often dictates its reactivity.”

Interesting facts

Interesting Facts about 3-(Trifluoromethyl)phenol

3-(Trifluoromethyl)phenol, also known as a substituted phenolic compound, has garnered significant interest in various fields due to its unique properties and potential applications. Here are some captivating insights:

  • **Chemical Structure**: The presence of the trifluoromethyl group (-CF3) significantly enhances the compound's lipophilicity, making it highly relevant in medicinal chemistry.
  • **Biological Activity**: This compound exhibits notable antibacterial activity, which opens avenues for its use in pharmaceuticals. Studies have indicated that it may inhibit the growth of certain pathogens.
  • **Industrial Use**: Beyond its biological implications, 3-(Trifluoromethyl)phenol is commonly utilized as a building block in the synthesis of agrochemicals and fluorinated materials.
  • **Research Interest**: Ongoing research focuses on its role in organic electronics and materials science, particularly in the development of new polymers and coatings.
  • **Fluorine Chemistry**: The trifluoromethyl group is a highly electronegative substituent, influencing the reactivity of the compound, making it a subject of interest for chemists studying fluorine chemistry.

As a fascinating compound, 3-(Trifluoromethyl)phenol exemplifies the power of fluorination in altering chemical properties, paving the way for innovative applications across chemistry and material science.

Synonyms
3-(Trifluoromethyl)phenol
98-17-9
3-Trifluoromethylphenol
3-Hydroxybenzotrifluoride
m-Hydroxybenzotrifluoride
m-trifluoromethylphenol
Phenol, 3-(trifluoromethyl)-
m-(Trifluoromethyl)phenol
alpha,alpha,alpha-Trifluoro-m-cresol
a,a,a-trifluoro-m-cresol
5-TRIFLUOROMETHYLPHENOL
NSC 9884
EINECS 202-645-5
3-Trifluoromethyl-phenol
MFCD00002299
m-CRESOL, alpha,alpha,alpha-TRIFLUORO-
DTXSID7052658
EC 202-645-5
NSC-9884
m-Cresol, .alpha.,.alpha.,.alpha.-trifluoro-
3-Hydroxy-alpha,alpha,alpha-trifluorotoluene
ALPHA,A,A-Trifluoro-m-cresol
3-trifluoromethylplienol
m-trifluoromethyl-phenol
3-trifluoromethyl phenol
meta-trifluoromethylphenol
3-(triluoromethyl)phenol
3-hydroxy benzotrifluoride
3-hydroxy-benzotrifluoride
m-CF3C6H4OH
meta-trifluoromethyl phenol
3-(trifluoromethyl) phenol
phenol, 3-trifluoromethyl-
R2R9N38UDY
SCHEMBL40389
CHEMBL57877
DTXCID8031231
NSC9884
3-(Trifluoromethyl)phenol, 99%
CHEBI:195128
BDBM108237
3-(1,1,1-trifluoromethyl)phenol
.alpha.,.alpha.-Trifluoro-m-cresol
BBL009723
STL141088
alpha,alpha,alpha,-trifluoro-m-cresol
AKOS000119745
alpha, alpha, alpha-trifluoro-m-cresol
CS-W010869
FH33135
PS-8757
AC-10892
M‐trifluoromethylphenol (Hit 5)
DB-028582
.alpha.,.alpha.,.alpha.-Trifluoro-m-cresol
NS00010084
T0436
EN300-20070
D70669
F0001-2315
Z104476676
1-TRIFLUOROMETHYL,3-HYDROXY-BENZENE (3-HYDROXI-TOLUENE,ALPHA,ALPHA,ALPHA-TRIFLUORO)
1-TRIFLUOROMETHYL,3-HYDROXY-BENZENE (3-HYDROXI-TOLUENE,ALPHA,ALPHA,ALPHA-TRIFLUORO)
m-Hydroxybenzotrifluoride ; 3-Hydroxybenzotrifluoride ; 3-(Trifluoromethyl)phenol ; alpha,alpha,alpha-Trifluoro-m-cresol
m-Hydroxybenzotrifluoride; 3-Hydroxybenzotrifluoride; 3-(Trifluoromethyl)phenol; alpha,alpha,alpha-Trifluoro-m-cresol