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[3-(Trifluoromethyl)phenyl]urea

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Identification
Molecular formula
C8H7F3N2O
CAS number
20959-08-8
IUPAC name
[3-(trifluoromethyl)phenyl]urea
State
State

At room temperature, [3-(Trifluoromethyl)phenyl]urea is typically a solid. It has a stable form which allows it to be manipulated in standard laboratory environments under ambient conditions.

Melting point (Celsius)
157.00
Melting point (Kelvin)
430.15
Boiling point (Celsius)
340.00
Boiling point (Kelvin)
613.15
General information
Molecular weight
206.17g/mol
Molar mass
206.1680g/mol
Density
1.4458g/cm3
Appearence

[3-(Trifluoromethyl)phenyl]urea is generally found as a crystalline solid. It appears colorless to light yellow in form, and it is typically not noted for any strong or distinct odor. The crystalline nature may exhibit a shimmer due to light refraction. It is often processed as a powder for chemical usage.

Comment on solubility

Solubility of [3-(trifluoromethyl)phenyl]urea (C8H7F3N2O)

[3-(trifluoromethyl)phenyl]urea exhibits unique solubility characteristics primarily attributed to its molecular structure. Here are some key points regarding its solubility:

  • Polar Nature: The presence of the urea functional group contributes to its polar characteristics, allowing for solubility in polar solvents.
  • Effect of Fluorine: The trifluoromethyl group enhances hydrophobicity, which may limit solubility in aqueous environments.
  • Solvent Compatibility: It is generally soluble in organic solvents such as methanol and ethanol, but has reduced solubility in water.
  • Temperature Influence: Like many organic compounds, solubility can increase with temperature, potentially altering its solubility profile based on the surrounding conditions.

In summary, while [3-(trifluoromethyl)phenyl]urea is soluble in various polar organic solvents, its solubility in water is limited due to the competing effects of the hydrophobic trifluoromethyl group. As such, solutions may require careful consideration of both solute and solvent characteristics to achieve the desired concentration and reactivity.

Interesting facts

Interesting Facts about [3-(Trifluoromethyl)phenyl]urea

[3-(Trifluoromethyl)phenyl]urea is a fascinating compound with unique chemical characteristics that make it a subject of interest in various fields, including medicinal chemistry and agrochemicals.

Key Characteristics

  • Structural Features: The presence of a trifluoromethyl group significantly enhances the compound's lipophilicity, important for its reactivity and interaction with biological molecules.
  • Biological Significance: Compounds with urea linkages are often explored for their potential as pharmaceuticals, making this particular compound noteworthy for its possible applications in drug design.
  • Fluorine's Role: The incorporation of fluorine atoms can improve metabolic stability and bioavailability, which is why fluorinated compounds are prevalent in drug development.

Applications and Research

This compound has been investigated for its potential as:

  • Herbicides: Due to its selective efficacy, compounds featuring the trifluoromethyl group can be utilized in developing safer, more effective herbicidal agents.
  • Pharmaceuticals: Its ability to interact with various biological targets makes it a candidate for studies related to treating specific diseases.

Fun Fact

In the world of chemistry, the trifluoromethyl group (-CF3) is often referred to as a "magic" group due to its ability to significantly alter the properties of organic compounds, leading to unexpected and often advantageous effects.

In summary, [3-(trifluoromethyl)phenyl]urea is not just a chemical substance; it embodies the intersection of chemistry and biology, where the innovative application of chemical knowledge can lead to breakthroughs in various scientific domains.

Synonyms
13114-87-9
[3-(trifluoromethyl)phenyl]urea
Urea, N-[3-(trifluoromethyl)phenyl]-
Didemethylfluometuron
(3-trifluoromethylphenyl)urea
Urea, N-(3-(trifluoromethyl)phenyl)-
QA3K6C5P54
(3-(Trifluoromethyl)phenyl)urea
NSC-136288
DTXSID0065355
(M-(TRIFLUOROMETHYL)PHENYL)UREA
TRIFLUOROMETHYL)PHENYL UREA, 3-(
DTXCID9034028
1-(3-(Trifluoromethyl)phenyl)urea
3-(TRIFLUOROMETHYL)PHENYLUREA
1-[3-(trifluoromethyl)phenyl]urea
N-[3-(trifluoromethyl)phenyl]urea
Urea, [3-(trifluoromethyl)phenyl]-
N-(3-Trifluoromethylphenyl)urea
3-Trifluoromethylphenylurea
Fluometuron-N,N-desmethyl
MFCD00025424
Urea, (3-(trifluoromethyl)phenyl)-
CHEMBL1338939
1-(3-(tri-fluoromethyl)phenyl)urea
1-[3-(tri-fluoromethyl)phenyl]urea
amino-N-[3-(trifluoromethyl)phenyl]amide
EINECS 236-040-2
NSC136288
NSC 136288
3-(alpha,alpha,alpha-Trifluoro-m-tolyl)urea
Urea, (alpha,alpha,alpha-trifluoro-m-tolyl)-
UNII-QA3K6C5P54
MLS000058790
SCHEMBL167618
SCHEMBL2236573
(3-trifluoromethyl-phenyl)-urea
SCHEMBL11373214
HMS2401M04
N-[3-(trifluoro-methyl)phenyl]urea
BDBM50427553
SBB023416
STK350561
AKOS000161408
FT79155
PS-6612
SDCCGMLS-0020472.P002
SMR000069055
SY081437
Urea,.alpha.,.alpha.-trifluoro-m-tolyl)-
DB-042004
3-(.alpha.,.alpha.-Trifluoro-m-tolyl)urea
CS-0037972
NS00021594
ST45138471
EN300-230477
SR-01000197063
3-(.alpha.,.alpha.,.alpha.-Trifluoro-m-tolyl)urea
SR-01000197063-1
Urea, (.alpha.,.alpha.,.alpha.-trifluoro-m-tolyl)-
F6660-3430
GF6