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Berberine chloride

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Identification
Molecular formula
C20H18ClNO4
CAS number
633-65-8
IUPAC name
3,10-dimethoxy-7-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-7-ium-2,9-diol;chloride
State
State

Berberine chloride is typically in a solid state at room temperature. It is a crystalline substance, and its solid form is utilized extensively in chemical and pharmacological research.

Melting point (Celsius)
204.00
Melting point (Kelvin)
477.15
Boiling point (Celsius)
374.30
Boiling point (Kelvin)
647.45
General information
Molecular weight
372.81g/mol
Molar mass
372.8120g/mol
Density
1.2630g/cm3
Appearence

Berberine chloride appears as a yellow crystalline powder. It is often noted for its bright yellow color, which is a characteristic feature of its alkaloid class.

Comment on solubility

Solubility of 3,10-Dimethoxy-7-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-7-ium-2,9-diol; Chloride

The solubility of 3,10-dimethoxy-7-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-7-ium-2,9-diol; chloride can be influenced by various factors, such as polarity, structural characteristics, and the presence of ionic charges. This compound, being a quaternary ammonium salt, generally exhibits properties akin to its class, resulting in notable solubility in certain solvents.

Key Factors Affecting Solubility:

  • Polarity: The presence of methoxy groups contributes to its polar character, enhancing solubility in polar solvents like water and methanol.
  • Ionic nature: As a salt, it is likely to dissolve well in polar solvents due to the ionic interactions.
  • Hydrogen bonding: The hydroxyl groups can engage in hydrogen bonding with water molecules, further promoting solubility.

Quotes from solubility studies often emphasize that “the degree of solubility significantly reflects the interaction between the solute and solvent molecules.” Thus, one might observe that:

  • In organic solvents, solubility might be limited.
  • In water, the ionization can lead to high solubility levels.

In conclusion, while specific solubility metrics for this compound may not be extensively documented, understanding its ionic and polar characteristics can provide insights into its behavior in various solvents.

Interesting facts

Interesting Facts About 3,10-Dimethoxy-7-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-7-ium-2,9-diol; Chloride

This compound, featuring a complex structure integral to the isoquinoline family, has intriguing implications both in research and potential applications. Below are some fascinating details about this unique compound:

  • Biodiversity and Natural Products: Many isoquinoline derivatives exhibit significant biological activity. This particular compound merits exploration for its potential therapeutic properties, including interactions with biological targets.
  • Mechanistic Insights: Compounds in the isoquinoline class may influence neurotransmitter systems, notably in studies relating to mood disorders. As scientists investigate its mechanisms, insights into neurochemistry may emerge.
  • Synthetic Challenges: The intricate structure of this compound emphasizes the complexity of synthesis in organic chemistry. Researchers often face challenges with stereochemistry and regioselectivity when creating such complex molecules.
  • Potential Pharmacological Applications: The presence of multiple methoxy groups may enhance drug-like properties, leading to compounds conducive for medicinal chemistry. Given its dual functionality as a heterocyclic compound, it could pave the way for new drug discovery.
  • Cultural Context: Some isoquinoline derivatives have historical uses in traditional medicine, showcasing the interplay between chemistry and culture. Understanding these traditional uses can guide modern pharmaceutical development.

In summary, 3,10-dimethoxy-7-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-7-ium-2,9-diol; chloride is not just a mere chemical entity; it represents a bridge between traditional knowledge and modern scientific inquiry. As researchers delve deeper, new layers of understanding may unfold, highlighting its potential contributions to both science and society.

Synonyms
Cissamine chloride
Cyclanoline chloride
l-alpha-N-Methylscoulerine
17472-50-3
13a-alpha-BERBINIUM, 2,9-DIHYDROXY-3,10-DIMETHOXY-7-METHYL-, CHLORIDE
3,10-dimethoxy-7-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-7-ium-2,9-diol;chloride
FC65965