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Cefuroxime

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Identification
Molecular formula
C16H16N4O8S
CAS number
55268-75-2
IUPAC name
3,3-dimethyl-6-[[5-methyl-3-(2-thienyl)isoxazole-4-carbonyl]amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
State
State

At room temperature, Cefuroxime exists as a solid powder. It is often found in a lyophilized form or as part of a suspension for reconstitution in pharmaceutical applications. Nonetheless, it remains stable under room temperature conditions provided it is stored properly in airtight containers to protect from moisture and light.

Melting point (Celsius)
237.00
Melting point (Kelvin)
510.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
424.39g/mol
Molar mass
0.0000g/mol
Density
1.8670g/cm3
Appearence

Cefuroxime typically appears as a white to off-white crystalline powder. It is usually supplied in the form of sodium salt for stability and solubility and is used in pharmaceutical formulations. When exposed to light or moisture, its appearance may change, indicating degradation and reduced efficacy.

Comment on solubility

Solubility of 3,3-Dimethyl-6-[[5-methyl-3-(2-thienyl)isoxazole-4-carbonyl]amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid

The solubility of this compound, known for its complex molecular structure, can vary significantly depending on the solvent used and external conditions. It is crucial to consider several factors when evaluating solubility:

  • Polarity of the solvent: The presence of polar functional groups in the compound may enhance solubility in polar solvents such as water or methanol.
  • Temperature: Generally, increasing the temperature of the solvent can improve the solubility of such organic compounds due to higher molecular motion.
  • pH levels: Being a carboxylic acid, the solubility may be influenced by the acidity or basicity of the solution, potentially affecting the ionization of the compound.

As a general trend, compounds with extensive functional groups tend to have better solubility in a broad range of solvents, however, “no universal rule applies,” and each compound must be characterized individually. Testing in various solvents may reveal optimal conditions for solubilization, making empirical data essential for practical applications. In laboratory settings, it’s wise to conduct solubility tests under different conditions to ascertain the ideal environment for this specific compound.

Interesting facts

Interesting Facts about 3,3-Dimethyl-6-[[5-methyl-3-(2-thienyl)isoxazole-4-carbonyl]amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

This complex molecule belongs to a class of compounds that have garnered attention for their diverse pharmacological activities. It demonstrates the beauty and intricacy of organic chemistry, with multiple functional groups and stereochemistry that make it a fascinating subject of study.

Key Highlights

  • Structure Complexity: The structure is characterized by a bicyclic core, exhibiting a unique combination of heteroatoms, which can influence its chemical reactivity and biological properties.
  • Biological Relevance: Compounds with isoxazole rings are often found in biologically active molecules, including drugs with antibiotic and anti-inflammatory properties. This suggests a potential for further exploration in medicinal chemistry.
  • Thienyl Interaction: The presence of a thienyl group may provide interesting electronic characteristics, potentially enhancing the compound's interactions with biological targets, especially in terms of selective binding.
  • Customizability: The ability to modify the dimethyl and carbonyl substitutions opens pathways for the design of analogs, which can lead to the discovery of molecules with improved efficacy or reduced toxicity.

As noted by renowned chemists, *"The magic of organic compounds lies in their ability to intertwine simplicity with complexity,"* making the study of such molecular architectures both challenging and rewarding. This compound stands as a perfect example of that principle, providing rich opportunities for research in both synthetic methods and biological evaluations.


In summary, the multifaceted nature of this compound invites a multidisciplinary approach involving organic synthesis, pharmacology, and material science, all aiming to unlock its full potential.