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Cloxacillin

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Identification
Molecular formula
C19H17ClN3O5S
CAS number
61-72-3
IUPAC name
3,3-dimethyl-7-oxo-6-[(3-oxo-3-phenoxy-2-phenyl-propanoyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
State
State

State: Solid at room temperature.

Melting point (Celsius)
176.00
Melting point (Kelvin)
449.15
Boiling point (Celsius)
275.00
Boiling point (Kelvin)
548.15
General information
Molecular weight
435.88g/mol
Molar mass
435.8840g/mol
Density
1.4500g/cm3
Appearence

Cloxacillin is a white to off-white crystalline powder. It is generally supplied in the form of a sodium salt, which may appear as a powder or in crystalline form. It is not very soluble in water but dissolves in organic solvents such as chloroform and DMSO. When in solution, it appears as a clear, colorless to very light yellow liquid.

Comment on solubility

Solubility of 3,3-dimethyl-7-oxo-6-[(3-oxo-3-phenoxy-2-phenyl-propanoyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

When exploring the solubility of 3,3-dimethyl-7-oxo-6-[(3-oxo-3-phenoxy-2-phenyl-propanoyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, several factors come into play:

  • Polarity: The presence of various functional groups such as carboxylic acids and amines commonly influences solubility in polar solvents.
  • Hydrophobic Interactions: The phenyl groups may interact with non-polar solvents, potentially reducing overall solubility in water.
  • pH Dependence: As a carboxylic acid, the solubility can be pH-dependent, likely increasing in higher pH environments where it may ionize.
  • Thermodynamic Factors: The enthalpy and entropy changes upon dissolving will also dictate solubility behavior.

In general, compounds with complex structures like this one tend to have variable solubility profiles, often necessitating specific conditions for optimal dissolution. It might be said that, as with many organic compounds, "like dissolves like"; thus, the solvent's characteristics will be crucial in determining how well this compound can be dissolved.

In summary: The solubility of this compound is likely influenced by its unique structural elements, leading to a diverse range of solubility in different solvents. Test in varying conditions is recommended for a comprehensive understanding of its solubility behavior.

Interesting facts

Interesting Facts about 3,3-Dimethyl-7-Oxo-6-[(3-Oxo-3-Phenoxy-2-Phenyl-Propanoyl)Amino]-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid

This intriguing compound, with a complex structure, belongs to a class of molecules that showcase the ingenuity of **chemical synthesis**. Here are some fascinating insights:

  • Structural Complexity: The compound is characterized by a bicyclic structure, which is not only unique but also enhances its pharmacological properties. Such compounds often have diverse applications in medicinal chemistry.
  • Biological Activity: Many compounds with similar frameworks have been investigated for their ability to interact with biological systems, potentially acting as enzyme inhibitors or receptor ligands. This raises the question: could this compound exhibit similar capabilities?
  • Pharmacological Potential: Compounds featuring both thiazolidine rings and various functional groups are often studied for their role in drug discovery, particularly in developing treatments for diseases like cancer and bacterial infections.
  • Synthetic Routes: The synthesis of such a compound typically involves multiple steps, including reactions that form the bicyclic structure, amide coupling, and incorporation of phenyl and phenoxy groups, showcasing the art of organic synthesis.
  • Research Significance: The unique configuration and functionalities of this compound make it a compelling subject of study in research settings, with potential implications for the development of next-generation therapeutics.

In essence, the exploration of 3,3-dimethyl-7-oxo-6-[(3-oxo-3-phenoxy-2-phenyl-propanoyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid not only illustrates the potential of synthetic chemistry but also embodies the challenges and rewards of creating novel compounds with pharmaceutical relevance.

Synonyms
Oprea1_676635
DTXSID60865334
3,3-Dimethyl-7-oxo-6-(3-oxo-3-phenoxy-2-phenylpropanamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid