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3,4-Dihydroisoquinolin-2-amine

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Identification
Molecular formula
C9H12N2
CAS number
4542-46-3
IUPAC name
3,4-dihydro-1H-isoquinolin-2-amine
State
State

At room temperature, 3,4-dihydroisoquinolin-2-amine is in a solid state, presenting itself as a crystalline powder.

Melting point (Celsius)
90.00
Melting point (Kelvin)
363.15
Boiling point (Celsius)
270.00
Boiling point (Kelvin)
543.15
General information
Molecular weight
146.21g/mol
Molar mass
146.1960g/mol
Density
1.1373g/cm3
Appearence

3,4-Dihydroisoquinolin-2-amine is a white to off-white crystalline powder. It is usually in solid form under standard conditions of temperature and pressure.

Comment on solubility

Solubility of 3,4-dihydro-1H-isoquinolin-2-amine

The solubility of 3,4-dihydro-1H-isoquinolin-2-amine, a compound known for its unique structural features, can be characterized by several important factors that influence its behavior in solvents. Understanding solubility is crucial for applications in pharmaceuticals and materials science.

Key Factors Affecting Solubility:

  • Polarity: The molecular structure of 3,4-dihydro-1H-isoquinolin-2-amine suggests moderate polarity, which allows for solubility in various polar solvents.
  • Hydrogen Bonding: The presence of amine functional groups enhances the ability to form hydrogen bonds with solvents, further improving solubility.
  • Solvent Type: This compound is expected to be soluble in alcohols, dimethyl sulfoxide (DMSO), and other similar polar aprotic solvents.
  • Temperature Influence: As with many organic compounds, increasing temperature generally increases solubility in a solvent.

In conclusion, while 3,4-dihydro-1H-isoquinolin-2-amine is not highly soluble in water, its solubility profile in various organic solvents can be optimized for specific applications. When considering solubility, it is essential to experiment under controlled conditions to determine the precise solubility limits, adapting to the desired use and solvent system.

Interesting facts

Interesting Facts about 3,4-Dihydro-1H-isoquinolin-2-amine

3,4-dihydro-1H-isoquinolin-2-amine is an intriguing organic compound that has captured the interest of researchers and chemists alike. This compound is particularly significant in the field of medicinal chemistry due to its potential biological activities. Here are some noteworthy aspects of this fascinating molecule:

  • Structural Uniqueness: The isoquinoline framework is quite unique, providing a rich platform for the synthesis of various derivatives. Its structure allows for interaction with biological targets in a manner that can lead to therapeutically relevant compounds.
  • Biological Applications: Compounds derived from isoquinoline have been studied for their roles in treating a range of conditions, including neurodegenerative diseases, cancer, and as anti-inflammatory agents. This makes 3,4-dihydro-1H-isoquinolin-2-amine a candidate for further research in pharmacology.
  • Synthetic Pathways: The synthesis of this compound often involves multi-step reactions, which can include cyclization and amination processes. Studying these pathways can provide insights into not only the compound itself but also the methodologies applicable to similar compounds.
  • Role in Natural Products: Isoquinoline derivatives are often found in various natural sources, such as plants. Understanding the biosynthesis of these compounds can lead to discoveries about their ecological roles and interactions.

As chemists continue to explore the broad implications of 3,4-dihydro-1H-isoquinolin-2-amine, they are likely to uncover more about its potential applications and benefits. The ongoing research in this area highlights the compound's importance in the continuous quest for new therapeutic agents.

Synonyms
4836-98-0
ISOQUINOLINE, 1,2,3,4-TETRAHYDRO-2-AMINO-
6SW9KP0INH
NSC 82330
BRN 0137593
N-Amino-1,2,3,4-tetrahydroisoquinoline
Isoquinoline, 2-amino-1,2,3,4-tetrahydro-
UNII-6SW9KP0INH
NSC-82330
DTXSID70197496
2-AMINO-1,2,3,4-TETRAHYDROISOQUINOLINE
5-20-06-00339 (Beilstein Handbook Reference)
2(1H)-Isoquinolinamine, 3,4-dihydro-
3,4-DIHYDRO-2(1H)-ISOQUINOLINAMINE
DTXCID80119987
Isoquinoline, 2-amino-1,2,3,4-tetrahydro-(8CI)
3,4-DIHYDROISOQUINOLIN-2(1H)-AMINE
1,2,3,4-TETRAHYDROISOQUINOLIN-2-AMINE
3,4-dihydro-1H-isoquinolin-2-amine
NSC82330
NCIOpen2_001260
SCHEMBL302485
IYANYSZUKHQLKL-UHFFFAOYSA-N
3,4dihydro-1H-isoquinolin-2-ylamine
AKOS005213538
N-Amino-1,3,4-tetrahydroisoquinoline
3,4-dihydro-1H-isoquinolin-2-ylamine
MB00779
Isoquinoline,2,3,4-tetrahydro-2-amino-
EN300-300578