Skip to main content

Hydroxyzine hydrochloride

ADVERTISEMENT
Identification
Molecular formula
C21H28ClN3O2
CAS number
2192-20-3
IUPAC name
3,4-dihydro-2H-1,4-benzoxazine-2-carbonyl(2-phenylethyl)ammonium;chloride
State
State

At room temperature, Hydroxyzine hydrochloride is in a solid state. It is usually supplied in a stabilized form when manufactured for medical use, often formulated into tablets or capsules.

Melting point (Celsius)
190.00
Melting point (Kelvin)
463.15
Boiling point (Celsius)
229.80
Boiling point (Kelvin)
502.95
General information
Molecular weight
374.90g/mol
Molar mass
374.9000g/mol
Density
1.2430g/cm3
Appearence

Hydroxyzine hydrochloride typically appears as a white to off-white, crystalline powder. It is hygroscopic, which means it can absorb moisture from the air. This compound is soluble in water, which gives it a particular utility in various pharmaceutical preparations.

Comment on solubility

Solubility of 3,4-dihydro-2H-1,4-benzoxazine-2-carbonyl(2-phenylethyl)ammonium;chloride

The solubility of 3,4-dihydro-2H-1,4-benzoxazine-2-carbonyl(2-phenylethyl)ammonium;chloride can be influenced by various factors due to its complex structure. As a quaternary ammonium salt, it exhibits notable characteristics in different solvent systems:

  • Water solubility: This compound is expected to have varying degrees of solubility in water, primarily due to the presence of the ammonium functional group, which generally enhances solubility in polar solvents.
  • Solvent polarity: It tends to be more soluble in polar solvents compared to non-polar solvents. This is attributed to its ionic nature, which can interact favorably with water molecules.
  • Temperature effects: Increased temperature often leads to higher solubility for many salts, including likely scenarios for this compound.

However, empirical solubility data would provide the most accurate perspective on its behavior in different environments. It is important to note that the presence of the bulky 2-phenylethyl group may hinder solvation, potentially making the compound less soluble in certain conditions. As observed in many organic compounds, the balance between hydrophilic and hydrophobic interactions is crucial in determining the overall solubility.

In conclusion, while the ammonium chloride functionality suggests good solubility in water, the actual solubility can vary greatly depending on external conditions and environmental factors.

Interesting facts

Interesting Facts about 3,4-Dihydro-2H-1,4-benzoxazine-2-carbonyl(2-phenylethyl)ammonium;chloride

3,4-Dihydro-2H-1,4-benzoxazine-2-carbonyl(2-phenylethyl)ammonium;chloride is a fascinating compound with intriguing properties and potential applications. Here are some noteworthy aspects:

  • Structural Diversity: This compound showcases a unique structural framework that combines a benzoxazine moiety with an ammonium-based side chain, which is quite rare in organic chemistry.
  • Bioactivity: Due to its structural components, it may exhibit bioactive properties, making it of interest in medicinal chemistry for potential therapeutic uses.
  • Versatility: The presence of the phenylethyl group can affect the pharmacokinetics and pharmacodynamics of the compound, highlighting its potential in drug design and delivery systems.
  • Synthetic Pathways: Chemists have developed various synthetic routes to create benzoxazine derivatives, showcasing the creativity and innovation involved in organic synthesis. This compound can serve as a template for synthesizing similar derivatives.

In the words of renowned chemist Linus Pauling, "The best way to have a good idea is to have lots of ideas." This compound exemplifies the exploration of ideas in the realm of organic chemistry. Researchers are continuously investigating the potential applications and functions of such compounds, which can lead to breakthroughs in pharmaceuticals and materials science.

Overall, 3,4-dihydro-2H-1,4-benzoxazine-2-carbonyl(2-phenylethyl)ammonium;chloride represents a captivating topic worth further investigation and study in a variety of scientific fields.

Synonyms
3,4-Dihydro-N-phenethyl-2H-1,4-benzoxazine-2-carboxamide hydrochloride
2H-1,4-BENZOXAZINE-2-CARBOXAMIDE, 3,4-DIHYDRO-N-PHENETHYL-, MONOHYDROCHLORIDE
22244-26-4
RefChem:1065145