Nicotinic acid riboside | Solubility of Things

Identification

Molecular formula

C₁₄H₁₈N₂O₅

CAS number

1341-23-7

IUPAC name

3,4,5-trihydroxy-6-[3-(1-methylpyrrolidin-2-yl)pyridin-1-ium-1-yl]tetrahydropyran-2-carboxylic acid

State

At room temperature, nicotinic acid riboside is a solid.

Melting point (Celsius)

234.00

Melting point (Kelvin)

507.15

Boiling point (Celsius)

463.00

Boiling point (Kelvin)

736.15

General information

Molecular weight

255.31g/mol

Molar mass

255.2610g/mol

Density

2.1730g/cm³

Appearence

Nicotinic acid riboside is typically a white to off-white crystalline solid. It may appear as a powder or crystalline granules, often being hygroscopic.

Comment on solubility

Solubility of 3,4,5-trihydroxy-6-[3-(1-methylpyrrolidin-2-yl)pyridin-1-ium-1-yl]tetrahydropyran-2-carboxylic acid

The solubility of 3,4,5-trihydroxy-6-[3-(1-methylpyrrolidin-2-yl)pyridin-1-ium-1-yl]tetrahydropyran-2-carboxylic acid, with the chemical formula C₁₄H₁₈N₂O₅, can be explored through various factors inherent to its molecular structure:

Hydrogen Bonding: The presence of multiple hydroxyl (-OH) groups enhances the potential for hydrogen bonding with solvents, particularly water. This typically indicates a higher solubility in polar solvents.
Ionic Character: The inclusion of a pyridinium group suggests ionic characteristics, which can further increase the solubility in polar aprotic solvents.
Molecular Weight: With a relatively moderate molecular weight, this compound may dissolve more readily compared to larger organic molecules.
Hydrophilicity vs Hydrophobicity: The balance between hydrophilic regions (due to hydroxyl and cationic groups) and potential hydrophobic regions in the tetrahydropyran cyclic component influences solubility. A predominance of hydrophilic sites should enhance water solubility.

In summary, one can anticipate that this compound would exhibit good solubility in aqueous solutions while potentially being less soluble in nonpolar organic solvents. This solubility profile can be critical, especially in applications involving biological systems or formulations where aqueous solubility is desired.

Interesting facts

Interesting Facts about 3,4,5-Trihydroxy-6-[3-(1-methylpyrrolidin-2-yl)pyridin-1-ium-1-yl]tetrahydropyran-2-carboxylic Acid

This fascinating compound, known as 3,4,5-trihydroxy-6-[3-(1-methylpyrrolidin-2-yl)pyridin-1-ium-1-yl]tetrahydropyran-2-carboxylic acid, offers rich potential for both scientific research and practical applications. Here are some intriguing aspects of this compound:

Complex Structure: The molecule features a complex arrangement, showcasing multiple functional groups, including hydroxyl groups (–OH) and a carboxylic acid group (–COOH), which contribute to its reactivity and solubility properties.
Bioactive Potential: Due to the presence of the pyridine and pyrrolidine moieties, this compound may exhibit interesting biological activities, making it a candidate for research in medicinal chemistry.
Synthesis Challenges: The synthesis of such a multi-functionalized compound can be intricate, often involving multiple steps of selective functionalization and protection strategies to achieve the desired structure.
Pharmaceutical Applications: Compounds with similar structural frameworks have been investigated for their roles as ligand-binding agents, indicating a potential in drug development and therapeutic applications.
Structure-Activity Relationship (SAR): Understanding how variations in its structure influence biological activity can provide critical insights in drug design and optimization strategies.

As researchers delve deeper into this intriguing compound, its properties and potential applications continue to unfold. Indeed, the intersection of chemistry and biology in such compounds remains a thrilling area of study, opening doors to new discoveries that could impact medicine and beyond.