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3,4,5-Trimethoxyamphetamine (TMA-5)

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Identification
Molecular formula
C18H23NO4
CAS number
22554-39-4
IUPAC name
3,4,5-trimethoxy-N-(1-methyl-2-phenyl-ethyl)benzamide
State
State

At room temperature, 3,4,5-trimethoxyamphetamine generally exists in a solid state.

Melting point (Celsius)
63.50
Melting point (Kelvin)
336.65
Boiling point (Celsius)
310.20
Boiling point (Kelvin)
583.35
General information
Molecular weight
297.37g/mol
Molar mass
297.3720g/mol
Density
1.1020g/cm3
Appearence

3,4,5-Trimethoxyamphetamine often appears as a crystalline solid. The pure compound typically possesses a whitish coloration, but impurities can lead to variations.

Comment on solubility

Solubility of 3,4,5-trimethoxy-N-(1-methyl-2-phenyl-ethyl)benzamide

The solubility of 3,4,5-trimethoxy-N-(1-methyl-2-phenyl-ethyl)benzamide can be characterized as follows:

  • Solvent Interaction: This compound is generally more soluble in organic solvents such as ethanol, methanol, and dichloromethane due to its nonpolar aromatic hydrocarbon structure.
  • Water Solubility: It exhibits limited solubility in water. As a result, while it may dissolve to some extent, its hydrophobic nature inhibits significant interaction with water molecules.
  • Temperature Dependence: Solubility may increase with temperature; heating can often enhance the dissolution of solid compounds in various solvents.
  • pH Influence: The solubility might also be affected by the pH of the solution. Adjusting the pH could alter the ionization state of the compound, thus influencing its solubility profile.
  • Practical Implications: In practical applications, solubility considerations are crucial for drug formulations and delivery systems. The limited water solubility indicates potential challenges when developing aqueous-based formulations.

In summary, while 3,4,5-trimethoxy-N-(1-methyl-2-phenyl-ethyl)benzamide has favorable solubility in organic solvents, its low solubility in water necessitates careful consideration in research and development.

Interesting facts

Interesting Facts about 3,4,5-trimethoxy-N-(1-methyl-2-phenyl-ethyl)benzamide

This compound, known as 3,4,5-trimethoxy-N-(1-methyl-2-phenyl-ethyl)benzamide, presents a fascinating example of how organic chemistry can lead to diverse applications and solutions. Here are some engaging insights about this unique compound:

  • Pharmacological Potential: Compounds like this one are often studied for their potential therapeutic effects, particularly in the fields of psychiatry and neurology. Researchers are interested in the compound's interaction with various receptors in the brain, which could lead to breakthroughs in treatments for mood disorders.
  • Structural Versatility: The structure of this compound includes multiple methoxy groups and a benzamide moiety, which enhances its ability to participate in various chemical reactions. This structural flexibility is crucial in the synthesis of more complex pharmaceuticals.
  • Natural Products Inspiration: Many synthetic compounds are inspired by naturally occurring substances. The inclusion of methoxy groups further emphasizes the importance of structure in biological activity, mimicking certain natural alkaloids known for their medicinal properties.
  • Research Focus: Current research often focuses on how compounds like this can serve as templates for developing new drugs. The ongoing study of its analogs helps in understanding the SAR (structure-activity relationship) which is vital for enhancing efficacy and reducing side effects.

In summary, 3,4,5-trimethoxy-N-(1-methyl-2-phenyl-ethyl)benzamide serves as a testament to the vast potential of organic compounds in medicinal chemistry. Its unique structure and properties allow it to be of interest in ongoing research and drug development.

Synonyms
18341-14-5
3,4,5-trimethoxy-N-(1-phenylpropan-2-yl)benzamide
3,4,5-Trimethoxy-N-(alpha-methylphenethyl)-benzamide
3,4,5-Trimethoxy-N-(alpha-methylphenethyl)benzamide
BRN 2672523
Benzamide, N-(alpha-methylphenethyl)-3,4,5-trimethoxy-
N-((1-Methyl-2-phenyl)ethyl)-3,4,5-trimethoxybenzamide
BENZAMIDE, 3,4,5-TRIMETHOXY-N-(alpha-METHYLPHENETHYL)-
SCHEMBL10144825
DTXSID10939716
3,4,5-Trimethoxy-N-(1-phenylpropan-2-yl)benzene-1-carboximidic acid