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3,4,5-Trimethoxy-N-(o-tolyl)benzamide

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Identification
Molecular formula
C17H19NO4
CAS number
139391-54-3
IUPAC name
3,4,5-trimethoxy-N-(o-tolyl)benzamide
State
State
At room temperature, 3,4,5-Trimethoxy-N-(o-tolyl)benzamide is in a solid state, presenting as a crystalline powder that is stable under standard storage conditions.
Melting point (Celsius)
159.50
Melting point (Kelvin)
432.65
Boiling point (Celsius)
572.40
Boiling point (Kelvin)
845.55
General information
Molecular weight
301.34g/mol
Molar mass
301.3200g/mol
Density
1.2371g/cm3
Appearence
3,4,5-Trimethoxy-N-(o-tolyl)benzamide is a white to off-white crystalline powder. It is typically characterized by its pure, opaque appearance and may exhibit a slightly greasy texture depending on the environmental conditions such as humidity and temperature.
Comment on solubility

Solubility of 3,4,5-trimethoxy-N-(o-tolyl)benzamide

The solubility of 3,4,5-trimethoxy-N-(o-tolyl)benzamide in various solvents is a topic of significant interest due to its potential applications in pharmaceuticals and organic synthesis. This compound, with its three methoxy groups, indicates a possibility of increased polarity, which generally influences solubility in polar solvents.

Key Points on Solubility:

  • Polar Solvents: The presence of methoxy groups may enhance solubility in polar solvents, such as water and alcohols, by forming hydrogen bonds.
  • Non-polar Solvents: However, the o-tolyl group could foster some solubility in non-polar solvents, suggesting potential compatibility with organic solvents like chloroform or hexane.
  • pH Influence: The solubility can be affected by the pH as well; for instance, changes that can alter the ionization state of the amide group may enhance aqueous solubility.
  • Temperature Dependence: Temperature can also play a critical role, as increased temperature generally enhances solubility by allowing more molecules to interact with solvent molecules.

In summary, predicting the solubility of 3,4,5-trimethoxy-N-(o-tolyl)benzamide requires consideration of the nature of the solvent, the surrounding temperature, and the pH of the solution. Variations in these factors can lead to a nuanced understanding of how this compound behaves in different environments.

Interesting facts

Interesting Facts about 3,4,5-Trimethoxy-N-(o-tolyl)benzamide

The compound 3,4,5-trimethoxy-N-(o-tolyl)benzamide, a derivative of benzamide, possesses several noteworthy characteristics that pique interest among chemists and researchers alike. Here are some fascinating details:

  • Structure and Functional Groups: This compound features a benzene ring substituted with three methoxy groups and an o-tolyl group. The presence of these functional groups contributes to its unique properties, making it a topic of interest in organic synthesis.
  • Biological Activity: Compounds like 3,4,5-trimethoxy-N-(o-tolyl)benzamide are often studied for their potential biological activities, such as antimicrobial and anti-inflammatory properties. Such investigations can lead to the development of new pharmaceuticals.
  • Synthetic Pathways: The synthesis of this compound may involve various synthetic pathways, including reactions like Friedel-Crafts acylation and methoxylation, showcasing the versatility of organic reactions in creating complex molecules.
  • Research Applications: This compound could serve as a valuable intermediate in the synthesis of more complex organic compounds, valuable in fields like medicinal chemistry and materials science.

As we explore compounds like 3,4,5-trimethoxy-N-(o-tolyl)benzamide, we gain insights into the intricate world of chemistry and the multifaceted nature of organic compounds. Understanding such structures opens doors to novel applications and therapeutic solutions in the ever-evolving landscape of chemical research.

Synonyms
3,4,5-trimethoxy-N-(2-methylphenyl)benzamide
740-12-5
BRN 3104690
p-BENZOTOLUIDIDE, 3,4,5-TRIMETHOXY-
3,4,5-Trimethoxy-p-benzotoluidide
DTXSID40224788
N-p-Toluyl 3,4,5-trimethoxy-benzamide [French]
Benzamide, 3,4,5-trimethoxy-N-(4-methylphenyl)-
N-p-Toluyl 3,4,5-trimethoxy-benzamide
2-12-00-00520 (Beilstein Handbook Reference)
DTXCID70147279
4129-98-0
662-442-6
Oprea1_741749
STK729953
AKOS002265585
AH-034/07291046