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3,4,5-Trimethoxybenzoic acid

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Identification
Molecular formula
C10H12O5
CAS number
118-41-2
IUPAC name
3,4,5-trimethoxybenzoic acid
State
State

At room temperature, 3,4,5-Trimethoxybenzoic acid is typically found as a solid. It is stable under standard conditions and does not vaporize easily.

Melting point (Celsius)
168.00
Melting point (Kelvin)
441.15
Boiling point (Celsius)
305.00
Boiling point (Kelvin)
578.15
General information
Molecular weight
212.20g/mol
Molar mass
212.1960g/mol
Density
1.4380g/cm3
Appearence

3,4,5-Trimethoxybenzoic acid appears as a white to off-white crystalline powder. It is usually odorless and has a characteristic crystalline structure common to aromatic carboxylic acids.

Comment on solubility

Solubility of 3,4,5-Trimethoxybenzoic Acid

3,4,5-trimethoxybenzoic acid, often abbreviated as TMB acid, demonstrates interesting solubility characteristics that can impact its applications in various fields. Here are some key points regarding its solubility:

  • Solubility in Water: 3,4,5-trimethoxybenzoic acid shows limited solubility in water due to its hydrophobic methoxy groups, which hinder its ability to interact with water molecules.
  • Solubility in Organic Solvents: This compound is much more soluble in non-polar organic solvents such as ethanol, dimethylsulfoxide (DMSO), and dichloromethane, making it suitable for various organic reactions and extractions.
  • Influence of pH: The solubility can also be affected by the pH of the solution. In acidic or highly basic conditions, one might observe an increase in solubility as the ionization state of the carboxylic acid group changes.
  • Temperature Dependence: Generally, the solubility of organic compounds like TMB acid tends to increase with temperature, which can be beneficial for processes requiring higher concentrations.

In summary, while 3,4,5-trimethoxybenzoic acid is sparingly soluble in water, it exhibits good solubility in many organic solvents. Considering its solubility characteristics is vital for optimizing its use in practical applications.

Interesting facts

Interesting Facts about 3,4,5-Trimethoxybenzoic Acid

3,4,5-trimethoxybenzoic acid is a fascinating organic compound that belongs to the class of benzoic acids, characterized by the presence of three methoxy groups attached to the aromatic ring. This unique structure not only contributes to its chemical properties but also to its potential applications in various fields.

Key Features:

  • Bioactive Properties: Research has suggested that compounds containing multiple methoxy groups can exhibit significant biological activities. This includes potential anti-inflammatory and antioxidant effects, making 3,4,5-trimethoxybenzoic acid intriguing for pharmaceutical research.
  • Natural Sources: This compound can be derived from certain natural sources, particularly plants. Its presence in nature often raises interest in studying plant extracts for their medicinal properties.
  • Synthetic Utility: Chemists often utilize this compound as a building block in synthetic organic chemistry. The methoxy groups can serve as useful sites for further functionalization and exploration of chemical reactivity.

"The structure of a compound defines its destiny." - Anonymous This quote resonates well with 3,4,5-trimethoxybenzoic acid, as its specific arrangement of substituents plays a crucial role in determining its chemical behavior and interactions.

Potential Applications:

  • Medicinal Chemistry: Exploring the compound's potential as a drug candidate for treating diseases.
  • Natural Products Chemistry: Investigating the role of this compound in various traditional herbal remedies and its efficacy.
  • Research Tool: Used in studies aimed at understanding the impact of methoxy substitutions on the properties of aromatic compounds.

In summary, 3,4,5-trimethoxybenzoic acid is not just a mundane compound; it is a gateway to exploring biochemical pathways, enhancing synthetic methods, and opening up avenues for innovative applications in various scientific domains. As our understanding of such compounds grows, so does the potential for discovering new therapeutic agents.

Synonyms
3,4,5-TRIMETHOXYBENZOIC ACID
118-41-2
Eudesmic acid
Trimethylgallic acid
Gallic acid trimethyl ether
Benzoic acid, 3,4,5-trimethoxy-
Tri-O-methylgallic acid
Veratric acid, 5-methoxy-
3,4,5-trimethoxy-benzoic acid
UNII-V5C9H0SC9F
NSC 2525
V5C9H0SC9F
MFCD00002501
CHEBI:454991
5-methoxy-veratric acid
NSC-2525
EINECS 204-248-2
AI3-21153
DTXSID3059472
NSC2525
EC 204-248-2
TRIMETHOPRIM IMPURITY J [EP IMPURITY]
TRIMEBUTINE MALEATE IMPURITY B [EP IMPURITY]
TRIMETHOPRIM IMPURITY J (EP IMPURITY)
3,4,5-Trimethoxy Benzoic Acid
TRIMEBUTINE MALEATE IMPURITY B (EP IMPURITY)
Trimethoprim EP Impurity J
Eudesmate
Trimethylgallate
Trimethylgallicacid
H5A
Trimebutine Imp. B (EP); Trimethoprim Imp. J (EP); 3,4,5-Trimethoxybenzoic Acid; Trimebutine Maleate Impurity B; Trimethoprim Impurity J
Tri-O-methylgallate
5-Methoxy-veratrate
TriOmethylgallic acid
Gallate trimethyl ether
Spectrum_000082
SpecPlus_000919
Veratric acid, 5methoxy
Spectrum2_000791
Spectrum3_000260
Spectrum4_001625
Spectrum5_000409
3,5-Trimethoxybenzoic acid
SCHEMBL6592
Oprea1_180796
BSPBio_001680
CBDivE_013176
CBDivE_014084
KBioGR_002029
KBioSS_000502
MLS002207176
DivK1c_007015
SPBio_000922
Benzoic acid,4,5-trimethoxy-
CHEMBL377172
3,4,5 trimethoxy benzoic acid
Benzoic acid, 3,4,5trimethoxy
DTXCID3033432
BDBM92458
KBio1_001959
KBio2_000502
KBio2_003070
KBio2_005638
KBio3_001180
BCP27297
HY-Y0084
STR02399
BBL009652
CCG-40169
s3862
STK246307
AKOS000113542
AC-2858
FT28525
PS-7989
NCGC00179094-01
DA-78623
SMR000112093
DB-347777
CS-0008360
NS00001871
T0705
EN300-19836
AE-641/30185043
Eudesmic acid;Gallic acid trimethyl ether;NSC 2525
Q3278222
3,4,5-Trimethoxybenzoic acid, ReagentPlus(R), 99%
F2191-0131
Z104475702
3,4,5-Trimethoxybenzoic acid, Vetec(TM) reagent grade, 99%
204-248-2