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Colchicine

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Identification
Molecular formula
C22H25NO6
CAS number
64-86-8
IUPAC name
3,4,5,14,15,16-hexamethoxy-9,10-dimethyl-tricyclo[10.4.0.02,7]hexadeca-1(16),2,4,6,12,14-hexaen-9-ol
State
State
Colchicine is typically a solid at room temperature. It is often encountered in its crystalline form, especially in laboratory settings and when manufactured for medicinal use.
Melting point (Celsius)
157.00
Melting point (Kelvin)
430.00
Boiling point (Celsius)
445.43
Boiling point (Kelvin)
718.58
General information
Molecular weight
399.44g/mol
Molar mass
399.4390g/mol
Density
1.6600g/cm3
Appearence

Colchicine is a pale yellow powdery substance. In pure form, it appears crystalline. It is sensitive to light and may gradually darken when exposed to it for extended periods. Though it is visually unassuming, colchicine is known for its potent biological effects.

Comment on solubility

Solubility of 3,4,5,14,15,16-hexamethoxy-9,10-dimethyl-tricyclo[10.4.0.02,7]hexadeca-1(16),2,4,6,12,14-hexaen-9-ol

The solubility of 3,4,5,14,15,16-hexamethoxy-9,10-dimethyl-tricyclo[10.4.0.02,7]hexadeca-1(16),2,4,6,12,14-hexaen-9-ol can be influenced by a variety of factors due to its complex structure and functional groups. Here are some key points to consider:

  • Polarity: The presence of multiple methoxy groups can enhance the polarity of the compound, potentially increasing its solubility in polar solvents like water.
  • Solvent Compatibility: This compound may be more soluble in organic solvents such as ethanol, methanol, or acetone, rather than non-polar solvents.
  • Hydrogen Bonding: The hydroxyl (-OH) group could participate in hydrogen bonding, which may aid in solubility in polar environments.
  • Temperature Effects: Solubility often increases with temperature, suggesting that heating the solvent may improve the dissolution of this compound.
  • Concentration Considerations: As with many complex organic molecules, the solubility may not be profound, thus requiring careful concentration management for effective use.

In summary, while this compound exhibits characteristics that may allow it to be somewhat soluble in polar solvents, the overall solubility profile will depend significantly on the solvent choice and conditions. Remember, as with all solubility assessments, experimental validation is essential to ascertain the practical solubility of this intricate compound.

Interesting facts

Interesting Facts About 3,4,5,14,15,16-Hexamethoxy-9,10-Dimethyl-Tricyclo[10.4.0.02,7]hexadeca-1(16),2,4,6,12,14-hexaen-9-ol

This compound, with its complex name, belongs to a unique class of organic molecules that exhibit a fascinating array of properties and applications. Here are a few noteworthy points about this tricyclic compound:

  • Structural Complexity: The structure of this compound is notably intricate, featuring multiple methoxy groups and a tricyclic backbone, which contributes to its diverse chemical behavior.
  • Natural Product Potential: Compounds of this type are often investigated for their potential as natural products, playing crucial roles in various biological systems.
  • Applications in Medicine: Research has shown that similar compounds can exhibit antibacterial, antifungal, and anticancer properties, making them of great interest in pharmaceutical development.
  • Organic Synthesis: The intricate arrangement of functional groups provides ample opportunities for organic synthesis, allowing chemists to explore new pathways and derivatives.
  • Polymorphic Behavior: This compound may demonstrate polymorphism, where it could exist in different crystalline forms, potentially affecting its reactivity and stability.

As scientists continue to examine such complex compounds, the potential for discovering new uses and understanding fundamental chemical processes grows significantly. As one researcher stated, *"The beauty of organic chemistry lies in its ability to surprise us with the endless variations and applications of molecular structures."* Hence, 3,4,5,14,15,16-hexamethoxy-9,10-dimethyl-tricyclo[10.4.0.02,7]hexadeca-1(16),2,4,6,12,14-hexaen-9-ol represents just one of the many fascinating puzzles awaiting exploration in the world of chemical compounds.

Synonyms
Schizandrin
Schizandrol A
Schisandrol A
Wuweizichun A
Wuweizi alcohol A
3,4,5,14,15,16-hexamethoxy-9,10-dimethyltricyclo[10.4.0.02,7]hexadeca-1(16),2,4,6,12,14-hexaen-9-ol
MFCD00905761
SCHEMBL2702845
Wuweizi alcohol A;Schisandrol A
CHEBI:80900
DTXSID20995843
MSK40206
AKOS015918158
FS65391
1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-5,6,7,8-tetrahydrodibenzo[a,c][8]annulen-6-ol
1ST40206
AS-17718
DB-055861
C17064
1,2,3,10,11,12-Hexamethoxy-6,7-dimethyl-5,6,7,8-tetrahydrodibenzo[a,c]cycloocten-6-ol #
Dibenzo(a,c)cycloocten-6-ol, 5,6,7,8-tetrahydro-6,7-dimethyl-1,2 3,10,11,12-hexamethoxy-,stereoisomer