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3,5-bis(trifluoromethyl)aniline

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Identification
Molecular formula
C8H5F6N
CAS number
328-93-8
IUPAC name
3,5-bis(trifluoromethyl)aniline
State
State

At room temperature, 3,5-bis(trifluoromethyl)aniline is a solid. It exists in crystalline form and is stable under standard conditions.

Melting point (Celsius)
52.00
Melting point (Kelvin)
325.15
Boiling point (Celsius)
188.00
Boiling point (Kelvin)
461.15
General information
Molecular weight
241.13g/mol
Molar mass
241.1550g/mol
Density
1.4896g/cm3
Appearence

3,5-Bis(trifluoromethyl)aniline appears as a white to slightly off-white crystalline solid. It may appear in powder or crystalline chunk form and is generally free from impurities that could alter its consistency or color.

Comment on solubility

Solubility of 3,5-bis(trifluoromethyl)aniline

3,5-bis(trifluoromethyl)aniline, with the chemical formula C10H8F6N, is a fascinating compound due to its unique structure, which significantly influences its solubility in various solvents.


In terms of solubility, the following points are noteworthy:

  • Polar and Non-Polar Solvents: Due to the presence of trifluoromethyl groups, this compound exhibits a preference for solubility in non-polar solvents. The electronegative fluorine atoms create a highly polar environment that can hinder interaction with polar solvents.
  • Water Solubility: 3,5-bis(trifluoromethyl)aniline is practically insoluble in water owing to its larger hydrophobic character introduced by the trifluoromethyl groups, which repels water molecules.
  • Organic Solvents: It tends to dissolve better in organic solvents such as dichloromethane, ethyl acetate, and other hydrocarbon-based solvents. This is attributed to the compatible non-polar or weakly polar environments of these solvents.
  • Temperature Dependence: The solubility may increase with temperature, as higher temperatures can disrupt intermolecular forces and promote better solvation.

In summary, the solubility characteristics of 3,5-bis(trifluoromethyl)aniline are largely dictated by its unique molecular attributes, making it an interesting compound for further study in various solvent systems.

Interesting facts

Interesting Facts about 3,5-bis(trifluoromethyl)aniline

3,5-bis(trifluoromethyl)aniline is a fascinating compound that belongs to the class of anilines, which are aromatic amines. This compound is particularly noteworthy due to the presence of two trifluoromethyl groups attached to the aniline structure, which significantly enhance its chemical properties. Here are some interesting aspects of this compound:

  • Fluorine Substitution: The trifluoromethyl groups increase the electronegativity and lipophilicity of the compound, making it uniquely active in various chemical reactions.
  • Applications: Due to its electronic properties, 3,5-bis(trifluoromethyl)aniline is used in the synthesis of advanced materials, agrochemicals, and pharmaceuticals.
  • Reactivity: This compound exhibits interesting reactivity profiles in electrophilic aromatic substitution reactions, where the trifluoromethyl groups can either activate or deactivate specific positions on the aromatic ring.
  • Biological Activity: Studies have shown that compounds with the trifluoromethyl group can possess a unique biological activity, making them candidates for anti-cancer and anti-inflammatory agents.
  • Environmental Considerations: The use of fluorinated compounds brings attention to environmental and toxicological concerns since their degradation products can be persistent in the environment.

As a compound of interest in modern chemistry, 3,5-bis(trifluoromethyl)aniline serves as an excellent example of how structural modifications can lead to diverse chemical behaviors and applications. Its unique properties and reactivities open up possibilities for new discoveries in both academic and industrial chemistry.

Synonyms
3,5-BIS(TRIFLUOROMETHYL)ANILINE
328-74-5
3,5-Di(trifluoromethyl)aniline
Benzenamine, 3,5-bis(trifluoromethyl)-
3,5-Bis(trifluoromethyl)benzenamine
3,5-Bis-trifluoromethyl-phenylamine
Aniline, 3,5-bis(trifluoromethyl)-
MFCD00000394
AI3-17666
alpha,alpha,alpha,alpha',alpha',alpha'-Hexafluoro-3,5-xylidine
NSC 3411
EINECS 206-335-0
3,5-bis-trifluoromethylaniline
BRN 0654318
DTXSID1059814
3,5-Xylidine, alpha,alpha,alpha,alpha,alpha,alpha-hexafluro-
3-12-00-02498 (Beilstein Handbook Reference)
NSC-3411
3,5-Xylidine, alpha,alpha,alpha,alpha',alpha',alpha'-hexafluoro-
NSC3411
WLN: FXFFR CZ EXFFF
3,5 bistrifluoromethylaniline
3,5-Bistrifluoromethylaniline
3,5-Bis-trifluoromethylanilin
BIDD:GT0502
SCHEMBL130383
3,5-bistrifluoromethyl aniline
LLV6H6898J
3,5-bis-trifluoromethyl-aniline
3.5-bis(trifluoromethyl)aniline
DTXCID2038576
Aniline,5-bis(trifluoromethyl)-
3,5-bis(trifluoromethyl)-aniline
3,5-bis-(trifluoromethyl)aniline
3,5-bis-(trifluoromethyl)-aniline
Benzenamine,5-bis(trifluoromethyl)-
3,5 -bis (trifluoromethyl) aniline
AKOS000119781
CS-W009500
HY-W008784
PS-7736
SB79857
3,5-Bis(trifluoromethyl)aniline, 97%
AC-10222
SY020744
DB-023899
A5875
B1324
NS00041841
5-Amino-a,a,a,a',a',a'-hexafluoro-m-xylene
EN300-19708
F2190-0471
Z104474858
3, .alpha.,.alpha.,.alpha.,.alpha.,.alpha.,.alpha.-hexafluro-
3, .alpha.,.alpha.,.alpha.,.alpha.',.alpha.',.alpha.'-hexafluoro-
.alpha.,.alpha.,.alpha.,.alpha.',.alpha.',.alpha.'-Hexafluoro-3,5-xylidine
3,5-Xylidine, .alpha.,.alpha.,.alpha.,.alpha.',.alpha.',.alpha.'-hexafluoro-