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Ioxitalamic acid

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Identification
Molecular formula
C16H21I3N2O6
CAS number
2276-90-6
IUPAC name
3,5-diacetamido-2,4,6-triiodo-benzoic acid;(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol
State
State

At room temperature, ioxitalamic acid is typically in a solid state. It is generally stable and does not react with other substances under normal laboratory conditions.

Melting point (Celsius)
230.00
Melting point (Kelvin)
503.15
Boiling point (Celsius)
320.00
Boiling point (Kelvin)
593.15
General information
Molecular weight
785.93g/mol
Molar mass
785.9310g/mol
Density
2.0000g/cm3
Appearence

Ioxitalamic acid is typically found as a white to off-white crystalline powder when pure. It has no distinct smell and is quite stable under standard laboratory conditions.

Comment on solubility

Solubility of 3,5-Diacetamido-2,4,6-triiodo-benzoic Acid

The solubility of 3,5-diacetamido-2,4,6-triiodo-benzoic acid, especially in various solvents, is influenced by its structural composition. Typically, compounds with multiple functional groups exhibit varied solubility profiles.

Factors Affecting Solubility

  • Polarity: The presence of polar amide groups (-C(O)NH-) contributes to an increased ability to dissolve in polar solvents such as water.
  • Iodine Substituents: The tri-iodo substituents tend to reduce the overall polarity, which can affect solubility in non-polar solvents.
  • Multiple Functional Groups: The combination of an acidic group (carboxylic acid) and amide functionalities enhances the potential for hydrogen bonding, promoting solubility in suitable solvents.

In contrast, (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol demonstrates a contrasting solubility character. Its structure allows for excellent solubility in polar solvents due to:

  • Hydroxyl Groups: The abundance of -OH groups significantly increases its hydrophilicity, making it readily soluble in water.
  • Methylamino Group: The existence of the methylamino group further enhances solubility, as it can participate in hydrogen bonding.

To summarize: Both compounds illustrate the complex relationship between molecular structure and solubility, with factors like polarity, functional groups, and intermolecular forces playing critical roles. It is essential to consider these aspects when predicting the solubility behavior of any chemical compound.

Interesting facts

Interesting Facts about 3,5-Diacetamido-2,4,6-triiodo-benzoic Acid and (2R,3R,4R,5S)-6-(Methylamino)hexane-1,2,3,4,5-pentol

This compound is a fascinating study in molecular complexity and implications in the biomedical field. Here are some key points about it:

  • Dual Functionality: This compound combines both a benzoic acid component with a polyol structure, indicating potential versatility in chemical reactivity and interactions.
  • Importance in Medicine: The presence of iodine atoms in the structure suggests utility in imaging and therapeutic applications, particularly in radiology and nuclear medicine.
  • Sugar Alcohol Influence: The pentol (sugar alcohol) portion may enhance solubility and biocompatibility, making it relevant for drug formulation.
  • Structural Diversity: This compound exemplifies the complexity that can arise from simple modifications to basic structures, demonstrating how variations in functional groups can significantly alter properties.
  • Research Potential: Its unique composition may lead to future studies in altering pharmacokinetic properties or improving bioavailability of therapeutic agents.

Overall, the interplay between its diacetamido and triiodinated components, in conjunction with its polyol chain, positions this compound as a critical subject for ongoing research in medicinal chemistry and pharmaceuticals. As research continues, potential applications in diagnostics and treatment could emerge, making this compound a focal point for chemists and researchers alike!

Synonyms
Meglumine diatrizoate
DIATRIZOATE MEGLUMINE
131-49-7
Meglumine amidotrizoate
Cardiografin
Cystografin
Angiovist 282
Unipaque
Renurix
Diatrizoate methylglucamine
Urovist Cysto
Hypaque Meglumine
Cystographin Dilute
Reno-M-Dip
Hypaque 60
Renograffin M-76
Methylglucamine diatrizoate
Hypaque M 30
Reno
Amidotrizoate meglumine
Hypaque 13.4
Hypaque-cysto
Reno-dip
Reno-30
Urovist Cysto Pediatric
Cystografin Dilute
Urovist Meglumine Diu/ct
RENO M 60
Reno-60
EINECS 205-024-7
UNII-3X9MR4N98U
Diatrizoic acid meglumine salt
3X9MR4N98U
D-Glucitol, 1-deoxy-1-(methylamino)-, 3,5-bis(acetylamino)-2,4,6-triiodobenzoate (salt)
Meglumine Amidotrizoate Injection
Angiografin
Diatrizoate meglumine (USP)
Diatrizoate meglumine [USP]
1-Deoxy-1-(methylamino)-D-glucitol 3,5-diacetamido-2,4,6-triiodobenzoate (salt)
131-49-7 (meglumine)
Renografin
Urovist
CHEBI:31812
DTXSID20897171
3,5-Bis(acetamido)-2,4,6-triiodbenzoesaeure, 1-desoxy-1-methylamino-D-glucit-salz
Renocal
RENOCAL COMPONENT DIATRIZOATE MEGLUMINE
RENOVIST COMPONENT DIATRIZOATE MEGLUMINE
ANGIOVIST COMPONENT DIATRIZOATE MEGLUMINE
GASTROVIST COMPONENT DIATRIZOATE MEGLUMINE
RENOGRAFIN COMPONENT DIATRIZOATE MEGLUMINE
SINOGRAFIN COMPONENT DIATRIZOATE MEGLUMINE
Glucitol, 1-deoxy-1-(methylamino)-, 3,5-diacetamido-2,4,6-triiodobenzoate (salt), D-
Reno-M
GASTROGRAFIN COMPONENT DIATRIZOATE MEGLUMINE
MD-GASTROVIEW COMPONENT DIATRIZOATE MEGLUMINE
MEGLUMINE AMIDOTRIZOATE (MART.)
MEGLUMINE AMIDOTRIZOATE [MART.]
(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentaol 3,5-diacetamido-2,4,6-triiodobenzoate
3,5-diacetamido-2,4,6-triiodobenzoic acid;(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol
Gastrografin Oral (Veterinary)
DIATRIZOATE MEGLUMINE (USP MONOGRAPH)
DIATRIZOATE MEGLUMINE [USP MONOGRAPH]
Diatrizoate, Meglumine
Meglumine, Diatrizoate
MD 60
Amidotrizoate, Meglumine
Diatrizoate, Methylglucamine
Methylglucamine, Diatrizoate
Hypaque (TN)
Urovist (TN)
Reno (TN)
SCHEMBL107036
CHEMBL1200839
HY-B0926B
MIKKOBKEXMRYFQ-WZTVWXICSA-N
DTXCID601326588
HMS2234F23
DIATRIZOATE MEGLUMINE [VANDF]
AKOS040744646
MEGLUMINE AMIDOTRIZOATE [WHO-DD]
DIATRIZOATE MEGLUMINE [GREEN BOOK]
TS-08111
DIATRIZOATE MEGLUMINE [ORANGE BOOK]
DIATRIZOIC ACID MEGLUMINE SALT [MI]
NS00075412
D02015
MEGLUMINE AMIDOTRIZOATE INJECTION [JAN]
DIATRIZOATE MEGLUMINE COMPONENT OF RENOCAL
DIATRIZOATE MEGLUMINE COMPONENT OF ANGIOVIST
DIATRIZOATE MEGLUMINE COMPONENT OF RENOVIST
DIATRIZOATE MEGLUMINE COMPONENT OF GASTROVIST
DIATRIZOATE MEGLUMINE COMPONENT OF RENOGRAFIN
DIATRIZOATE MEGLUMINE COMPONENT OF SINOGRAFIN
DIATRIZOATE MEGLUMINE COMPONENT OF GASTROGRAFIN
Q27114690
DIATRIZOATE MEGLUMINE COMPONENT OF MD-GASTROVIEW
205-024-7