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Pyrazinamide Hydrochloride

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Identification
Molecular formula
C7H10ClN7O
CAS number
18983-36-5
IUPAC name
3,5-diamino-6-chloro-N-(diaminomethylene)pyrazine-2-carboxamide;hydrochloride
State
State

At room temperature, Pyrazinamide Hydrochloride is in a solid state. It is typically handled as a powder or crystalline substance in laboratory settings.

Melting point (Celsius)
189.00
Melting point (Kelvin)
462.15
Boiling point (Celsius)
321.10
Boiling point (Kelvin)
594.25
General information
Molecular weight
256.11g/mol
Molar mass
256.1070g/mol
Density
1.2810g/cm3
Appearence

Pyrazinamide Hydrochloride appears as a white to off-white crystalline powder. It is often available in solid form and can appear as fine granules or small crystals.

Comment on solubility

Solubility of 3,5-Diamino-6-chloro-N-(diaminomethylene)pyrazine-2-carboxamide;hydrochloride

The solubility of 3,5-diamino-6-chloro-N-(diaminomethylene)pyrazine-2-carboxamide; hydrochloride is influenced by its ionic nature due to the presence of the hydrochloride moiety. Some key points regarding its solubility are:

  • Water Solubility: This compound is expected to be highly soluble in water because the hydrochloride form increases its polarity.
  • Solvent Compatibility: Solubility may also vary in organic solvents. It's important to test solubility in various solvents such as ethanol or methanol to explore its versatility.
  • pH Influence: The solubility can be affected by the pH of the solution, with more acidic environments often enhancing solubility.
  • Temperature Dependency: Generally, solubility tends to increase with temperature, so heating may enhance its dissolution.

In summary, while the 3,5-diamino-6-chloro-N-(diaminomethylene)pyrazine-2-carboxamide; hydrochloride is highly soluble in water, its solubility characteristics should be carefully evaluated in the context of intended applications, as different environments and formulations may yield varying results. Always consider the necessity of conducting empirical solubility tests under controlled conditions to confirm these predictions.

Interesting facts

Interesting Facts about 3,5-Diamino-6-chloro-N-(diaminomethylene)pyrazine-2-carboxamide Hydrochloride

This compound, known for its complex structure, holds significance in both pharmaceutical chemistry and materials science. Its unique combination of amino and chloro substituents allows it to interact with various biological systems, showcasing potential for therapeutic applications.

Key Highlights

  • Pharmacological Interest: This compound may act as an effective agent in various therapeutic contexts, particularly in the realm of antimicrobial and anticancer research.
  • Chemical Versatility: Due to the presence of functional groups like amino and carboxamide, it can participate in diverse synthetic pathways, leading to the creation of novel chemical entities.
  • Potential Applications: The unique properties of this compound pave the way for its application in drug design, particularly in creating molecules that target specific enzymes or receptors in living organisms.
  • Historical Significance: Studying derivatives of pyrazines has contributed to advancements in developing new medication strategies, making compounds like this an exciting area of research.

Moreover, the presence of a hydrochloride salt form enhances its solubility, which can significantly impact its bioavailability and pharmacokinetics. Researchers continually explore its interactions with biological macromolecules, emphasizing its potential as a lead compound in drug development.

Quote from a Research Perspective

"The analysis of such complex compounds teaches us about the vital roles that molecular structure plays in biological activity and therapeutic potential." - A noted chemist.

As research continues in this field, the possibilities for 3,5-diamino-6-chloro-N-(diaminomethylene)pyrazine-2-carboxamide hydrochloride and its derivatives remain expansive, positioning it as an intriguing subject for future scientific exploration.

Synonyms
Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, monohydrochloride
AMILORIDE HYDROCHLORIDE
2016-88-8
Amiloride chloride
Amiloride HCl anhydrous
Amiloride hydrochloride hydrate
Amiloride (hydrochloride)
Amiloride hydrochloride anhydrous
amilorida hydrochloride
3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide hydrochloride
MLS000028442
DTXSID2024452
CHEBI:84743
N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride
N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide monohydrochloride
3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide;hydrochloride
Amiloride (hydrochloride) (Standard)
7M458Q65S3
SMR000058414
3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide hydrochloride
N-Amido-3,5-diamino-6-chloropyrazine carboxamide hydrochloride dihydrate
Amiloride * HCl
CAS-2016-88-8
Amiloride Hydrocholride
SR-01000000059
UNII-7M458Q65S3
3,5-diamino-N-[amino(imino)methyl]-6-chloropyrazine-2-carboxamide hydrochloride
MFCD00058197
Opera_ID_212
SCHEMBL41233
MLS001148092
SPECTRUM1500112
CHEMBL540851
HY-B0285AR
HY-B0285A
Amiloride hydrochloride (Midamor)
ACHKKGDWZVCSNH-UHFFFAOYSA-N
HMS1920C03
Pharmakon1600-01500112
BCP15584
Tox21_201386
Tox21_303068
Tox21_500111
CCG-38934
HB1010
MFCD03703482
NSC755847
s1811
AKOS015955970
AKOS030241719
FS-4063
KS-5339
LP00111
NCGC00024443-04
NCGC00093608-01
NCGC00093608-02
NCGC00093608-03
NCGC00093608-04
NCGC00180909-01
NCGC00257079-01
NCGC00258937-01
NCGC00260796-01
1ST14673
AC-12745
AC-32027
DA-60992
A2599
CS-0694827
EU-0100111
NS00093524
SW196333-4
Amiloride, Hydrochloride - CAS 2016-88-8
A 7410
EN300-10850183
SR-01000000059-2
SR-01000000059-4
Q27158032
3,5-diamino-6-chloro-n-(diaminomethylene) pyrazinecarboxamide monohydrochloride
3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide;hydron;chloride
Amiloride hydrochloride (3,5-Diamino-N-(aminoiminomethyl)-6-chloropyraZinecarboxamide)