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3,5-diiodopyridin-4-one

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Identification
Molecular formula
C5H3INO2
CAS number
32478-02-4
IUPAC name
3,5-diiodo-1H-pyridin-4-one
State
State

At room temperature, 3,5-diiodo-1H-pyridin-4-one is typically in a solid state. Its high density and defined crystal structure contribute to its stability as a solid compound under normal conditions.

Melting point (Celsius)
222.00
Melting point (Kelvin)
495.15
Boiling point (Celsius)
315.00
Boiling point (Kelvin)
588.15
General information
Molecular weight
329.90g/mol
Molar mass
329.8990g/mol
Density
3.2180g/cm3
Appearence

3,5-Diiodo-1H-pyridin-4-one typically appears as a pale yellow to off-white crystalline solid. It may be available in a powdered form or crystallized structures, depending on its preparation and storage conditions.

Comment on solubility

Solubility of 3,5-Diiodo-1H-pyridin-4-one

The solubility of 3,5-diiodo-1H-pyridin-4-one showcases intriguing characteristics that are driven by its unique molecular structure. This compound, which contains iodine substituents, often tends to exhibit low solubility in polar solvents. Here are some key points to consider:

  • Polarity: The introduction of iodine atoms, which are relatively large and non-polar, can significantly influence the overall polarity of the compound.
  • Solvent Interaction: This compound is generally more soluble in non-polar solvents such as chloroform or benzene than in water, highlighting the role of solvent compatibility in solubility.
  • Hydrogen Bonding: The presence of the nitrogen atom might allow for limited hydrogen bonding with polar solvents, potentially enhancing its solubility to a minor extent.

In summary, while 3,5-diiodo-1H-pyridin-4-one may exhibit certain solubility parameters, it is essential to remember that its solubility can primarily be influenced by the solvent choice and the specific interactions at play. As with many organo-heterocyclic compounds, careful consideration of the solvent environment is crucial for predicting solubility outcomes.

Interesting facts

Interesting Facts about 3,5-Diiodo-1H-pyridin-4-one

3,5-Diiodo-1H-pyridin-4-one is a fascinating compound that belongs to the class of heterocyclic aromatic compounds. Its unique structure and notable properties make it a subject of considerable interest in various fields, particularly in organic chemistry and medicinal chemistry.

Chemical Significance

  • Heterocyclic Nature: This compound features a pyridine ring, which is a six-membered aromatic ring containing one nitrogen atom. Pyridines are known for their diverse chemical reactivity.
  • Iodine Substitution: The presence of two iodine atoms at the 3 and 5 positions of the pyridine ring significantly affects its reactivity and stability, often enhancing the compound's ability to participate in various chemical reactions.

Biological Relevance

  • Pharmaceutical Applications: Compounds like 3,5-diiodo-1H-pyridin-4-one have garnered attention for their potential as pharmaceutical agents, particularly in the development of new antibiotics and antitumor drugs.
  • Mechanism of Action: The incorporation of iodine in organic compounds often influences their mechanisms of action, providing a pathway for the development of novel therapeutic agents.

Research Potential

Current research is focused on understanding how modifying the structure of pyridine derivatives can lead to enhanced biological activity. Scientists are exploring:

  • Methods for synthesizing derivatives of this compound.
  • Its interaction with biological systems and potential toxicological effects.

As noted by many researchers, "The introduction of halogens such as iodine can significantly enhance biological activity, making these compounds prime candidates for drug development." The ongoing exploration of 3,5-diiodo-1H-pyridin-4-one holds promise not only in chemistry but also in the quest for effective medicinal compounds.

Synonyms
Iopydone
7153-08-4
3,5-Diiodo-4-pyridone
Iopydon
Hytrast
3,5-Diiodo-4(1H)-pyridone
4(1H)-Pyridinone, 3,5-diiodo-
component of Hytrast
Iopidona
Jopydonum
Hytrast (VAN)
Iopydonum
Iopydonum [INN-Latin]
Iopidona [INN-Spanish]
Iopydone (USAN)
NSC 135284
NSC-135284
J6B56XB19T
4(1H)-PYRIDONE, 3,5-DIIODO-
Iopydone [USAN:INN:BAN:JAN]
IOPYDONE [USAN]
IOPYDONE [INN]
IOPYDONE [MI]
EINECS 226-969-1
IOPYDONE [MART.]
IOPYDONE [WHO-DD]
BRN 1447538
UNII-J6B56XB19T
DTXSID9063954
3,5-Diiodo-4(1H)-pyridinone
component of Hytrast (Salt/Mix)
Iopydonum (INN-Latin)
Iopidona (INN-Spanish)
IOPYDONE (MART.)
5-21-07-00164 (Beilstein Handbook Reference)
iopidone
DTXCID2041965
226-969-1
frpfevlofnakbs-uhfffaoysa-n
3,5-Diiodopyridin-4-ol
3,5-Diiodo-4-hydroxypyridine
5579-93-1
3,5-diiodopyridin-4(1H)-one
3,5-Diiodo-1H-pyridin-4-one
MFCD00023554
DJP
NSC135284
4-Pyridinol, 3,5-diiodo-
3,5-Diiodo-4-pyridinol
4-HYDROXY-3,5-DIIODOPYRIDINE
4-Pyridinol,5-diiodo-
MLS006011639
4(1H)-Pyridone,5-diiodo-
SCHEMBL666661
WLN: T6M DVJ CI EI
4(1H)-Pyridinone,5-diiodo-
3,5-diiodo-4-hydrox-ypyridine
CHEMBL2104367
3 pound not5-Diiodopyridin-4-ol
NSC60547
NSC-60547
AKOS000631308
AKOS015899046
AS-20011
SMR002530268
SY040052
DB-081225
CS-0036290
NS00033398
D04587
EN300-109702
W12571
W18704
AC-907/25014036
Q27281264