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Trimetazidine dihydrochloride

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Identification
Molecular formula
C14H23ClN2O
CAS number
13171-25-0
IUPAC name
3,5,7-trimethyl-1-(2-pyrrolidin-1-ium-1-ylpropyl)-3H-azepin-2-one;chloride
State
State

At room temperature, trimetazidine dihydrochloride is typically in a solid state. It is available in pharmaceutical preparations in tablet or powdered form, commonly for medicinal purposes to treat angina and other conditions. The compound is stable under normal conditions and is not volatile.

Melting point (Celsius)
140.00
Melting point (Kelvin)
413.00
Boiling point (Celsius)
100.00
Boiling point (Kelvin)
373.00
General information
Molecular weight
292.82g/mol
Molar mass
292.8220g/mol
Density
1.2000g/cm3
Appearence

Trimetazidine dihydrochloride appears as a white to almost white crystalline powder. It is odorless and has a slightly bitter taste. Being a salt form, it is more stable than its base counterparts, often found in tablet or powder form for medicinal uses.

Comment on solubility

Solubility of 3,5,7-trimethyl-1-(2-pyrrolidin-1-ium-1-ylpropyl)-3H-azepin-2-one; chloride

The solubility of 3,5,7-trimethyl-1-(2-pyrrolidin-1-ium-1-ylpropyl)-3H-azepin-2-one; chloride can be quite intriguing due to its complex structure. This compound is characterized by both hydrophilic and hydrophobic regions, which influences its solubility in various solvents.

Factors Affecting Solubility:

  • Polarity: The presence of the pyrrolidin-1-ium moiety adds a positive charge, making the compound more soluble in polar solvents, such as water.
  • Hydrogen Bonding: The functional groups can engage in hydrogen bonding, significantly increasing solubility in solvent systems that can donate or accept hydrogen bonds.
  • Temperature: As with many organic compounds, solubility typically increases with temperature; thus, heating the solution may enhance the dissolution of this compound.

Overall, it can be stated that while this compound may be *sparingly soluble* in cold water, it is likely to dissolve better in organic solvents like methanol or ethanol, where both polar and nonpolar interactions can occur. Therefore, when working with this compound, one should consider the choice of solvent based on the intended application and the desired concentration.

Interesting facts

Interesting Facts about 3,5,7-Trimethyl-1-(2-pyrrolidin-1-ium-1-ylpropyl)-3H-azepin-2-one; Chloride

This fascinating compound belongs to a group of chemicals known for their diverse applications in the field of synthetic chemistry and pharmaceuticals. Its structure features a unique combination of an azepine ring and a pyrrolidinium group, making it an interesting subject of study.

Unique Structural Features

  • Azepine Ring: The azepine structure provides properties that can be manipulated to influence biological activity.
  • Pyrrolidinium Substituent: This portion of the compound enhances the compound's solubility and potential interaction with biological systems.

Applications and Research

The versatility of 3,5,7-trimethyl-1-(2-pyrrolidin-1-ium-1-ylpropyl)-3H-azepin-2-one; chloride has intrigued researchers in multiple disciplines:

  • Pharmacology: It could serve as a lead compound for the development of new medications, especially in treating neurodegenerative diseases.
  • Synthetic Chemistry: It is often used as a building block in the synthesis of more complex molecules.

Why Study This Compound?

Understanding the properties and reactions of this compound can lead to innovations in:

  • Drug Design: By modifying the azepine ring, chemists can create derivatives with enhanced efficacy and selectivity.
  • Materials Science: The unique structural attributes may allow for the creation of new materials with specialized functions.

As we continue to explore this compound, the potential for new discoveries and applications remains vast. Indeed, as one researcher put it, "The complexity of chemical structures often opens the door to groundbreaking discoveries."

Synonyms
1900-35-2
2H-Azepin-2-one, 1,3-dihydro-1-((2-methyl-2-(1-pyrrolidinyl)ethyl)-3,5,7-trimethyl-, hydrochloride