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Sanguinarine

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Identification
Molecular formula
C20H14NO4
CAS number
2447-54-3
IUPAC name
3,9,10-trimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-2-ol
State
State

At room temperature, sanguinarine is a solid. It is typically handled as a powder form in laboratory settings.

Melting point (Celsius)
279.50
Melting point (Kelvin)
552.65
Boiling point (Celsius)
485.15
Boiling point (Kelvin)
758.30
General information
Molecular weight
334.34g/mol
Molar mass
334.3610g/mol
Density
1.3600g/cm3
Appearence

Sanguinarine typically appears as a bright red-orange crystalline powder. It is known for its intense color, making it identifiable in mixtures. The exact shade can sometimes depend on the crystal size and purity.

Comment on solubility

Solubility of 3,9,10-trimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-2-ol

The solubility of 3,9,10-trimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-2-ol can be quite fascinating, as it is influenced by various factors including its molecular structure and environmental conditions. Generally, compounds with multiple methoxy groups tend to show enhanced solubility in organic solvents, especially in polar solvents.

  • Polar solvents: The presence of methoxy groups can make the compound more compatible with polar solvents due to dipole interactions.
  • Non-polar solvents: Conversely, the compound may exhibit reduced solubility in non-polar solvents, as the hydrophobic regions might dominate over the hydrophilic characteristics of the methoxy groups.
  • pH Influence: The solubility may also be affected by the pH of the solution, particularly if there are ionizable groups present in the compound, which can lead to variations in solubility.

In the context of practical applications, understanding and predicting the solubility of this compound is essential for processes such as drug formulation. As a general remark, one could assert that:

“The solubility potential is as much about the liquid medium as it is about the solute itself.”

In summary, while the precise solubility of 3,9,10-trimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-2-ol may require empirical testing for specific solvents, an understanding of its methoxy functionalities suggests a favorable solubility profile in suitable polar environments.

Interesting facts

Interesting Facts about 3,9,10-trimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-2-ol

This complex compound, known for its intricate structure and diverse biological activities, is a fascinating subject of study for chemists and pharmacologists alike. Here are some intriguing aspects of this unique molecule:

  • Structural Complexity: The compound features a distinctive isoquinoline core, which is a fusion of two aromatic rings. This configuration contributes to its interesting chemical properties and biological activities.
  • Biodiversity and Natural Sources: Compounds similar to this one are often found in various plant species, indicating a potential role in traditional medicine. The study of these natural sources has led to discoveries about their therapeutic potentials.
  • Biological Activity: Research has suggested that similar isoquinoline-based compounds exhibit a range of pharmacological effects that could include anti-inflammatory, antitumor, and neuroprotective properties. This broad spectrum makes them valuable in medicinal chemistry.
  • Potential Applications: Given its structural features, this compound could be investigated for applications in pharmaceuticals, especially in the development of new therapeutic agents aimed at treating neurological disorders and cancers.
  • Synthetic Adaptability: The synthesis of such a complex structure poses interesting challenges but also opportunities to explore innovative organic synthesis techniques. Scientists continually seek efficient pathways to produce these compounds, enhancing their availability for research.

In summary, 3,9,10-trimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-2-ol represents a blend of natural inspiration and synthetic ambition. Its diverse properties warrant further exploration, making it a subject of significant interest in the field of chemistry.

Synonyms
(+/-)-Isocorypalmine
Isocorypalmine, DL-
(R,S)-Isocorypalmine
DL-Tetrahydrocolumbamine
Isocorypalmine, (+/-)-
(R,S)-Tetrahydrocolumbamine
Isocorypalmine DL-form [MI]
6487-33-8
UNII-YHT108XMMM
YHT108XMMM
(+/-)-Alkaloid L from corydalis
3,9,10-trimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-2-ol
CHEMBL3780481
6H-Dibenzo(a,g)quinolizin-2-ol, 5,8,13,13a-tetrahydro-3,9,10-trimethoxy-
(+-)-Isocorypalmine
SCHEMBL680031
3,9,10-trimethoxyberbin-2-ol
CHEBI:140671
BDBM50152836
5,8,13,13-Tetrahydro-3,9,10-trimethoxy-6H-dibenzo(a,q)quinolizin-2-ol
6H-Dibenzo(a,q)quinolizin-2-ol, 5,8,13,13a-tetrahydro-3,9,10-trimethoxy-
AKOS032947778
6989-84-0
Q27294528