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Phthalic anhydride

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Identification
Molecular formula
C8H4O3
CAS number
85-44-9
IUPAC name
3a,4,7,7a-tetrahydroisobenzofuran-1,3-dione
State
State

Phthalic anhydride is typically a solid at room temperature. It is highly susceptible to moisture, becoming phthalic acid if exposed to water, hence it is often found stored under dry conditions.

Melting point (Celsius)
131.00
Melting point (Kelvin)
404.15
Boiling point (Celsius)
295.00
Boiling point (Kelvin)
568.15
General information
Molecular weight
148.12g/mol
Molar mass
148.1160g/mol
Density
1.5270g/cm3
Appearence

Appearance: Phthalic anhydride appears as a white solid in its pure form. It can exist as either a crystalline substance or a fine powder. This compound is known for subliming readily to form vapor when heated.

Comment on solubility

Solubility of 3a,4,7,7a-tetrahydroisobenzofuran-1,3-dione

The solubility of 3a,4,7,7a-tetrahydroisobenzofuran-1,3-dione is influenced by several factors, primarily its molecular structure and interactions with solvents. Here’s a breakdown of its solubility characteristics:

  • Polarity: The compound features both polar and non-polar groups, which can lead to variable solubility in different solvents.
  • Solvent Interaction: It is expected to be soluble in polar solvents such as water, methanol, and ethanol due to its potential to form hydrogen bonds.
  • Aromatic Nature: Its aromatic structure may also grant some solubility in non-polar solvents, though to a lesser extent.
  • Temperature Dependency: As with many organic compounds, solubility can increase with temperature; thus, heating may enhance its solubility in common solvents.

Overall, the solubility of 3a,4,7,7a-tetrahydroisobenzofuran-1,3-dione can be considered moderate, with favorable conditions being needed to optimize its dissolution in various solvents. Understanding these properties is advantageous for practical applications and further research.

Interesting facts

Interesting Facts about 3a,4,7,7a-Tetrahydroisobenzofuran-1,3-dione

3a,4,7,7a-tetrahydroisobenzofuran-1,3-dione is a fascinating compound that belongs to the category of diketones, notable for its unique structure and potential applications in various fields. Here are some intriguing insights into this compound:

  • Chemical Structure: The compound features a fused bicyclic framework which incorporates both a dione functional group and a tetrahydroisobenzofuran moiety, contributing to its intriguing reactivity.
  • Biological Significance: Diketones like this one often demonstrate significant biological activities, making them of keen interest in medicinal chemistry, particularly as potential anti-inflammatory or antimicrobial agents.
  • Synthetic Pathways: Its synthesis can involve multiple strategies, including the use of cyclization reactions, illustrating the creativity required in organic synthesis.
  • Structure-Activity Relationship (SAR): The positioning of functional groups within the compound can lead to variations in activity, allowing chemists to explore modifications for enhanced properties.
  • Potential Applications: Due to its structural uniqueness, this compound could be explored for use in agrochemicals or as a building block for more complex organic molecules.

Scientists and chemistry students alike often find compounds like 3a,4,7,7a-tetrahydroisobenzofuran-1,3-dione intriguing due to their potential to bridge the knowledge between structure and function. As highlighted by renowned chemist Robert H. Grubbs, "The beauty of chemistry lies in understanding how the arrangement of atoms in a molecule results in unique properties."

In conclusion, exploring the properties and applications of this compound opens the door to a better understanding of organic chemistry and its real-world implications.

Synonyms
85-43-8
1,2,3,6-Tetrahydrophthalic anhydride
TETRAHYDROPHTHALIC ANHYDRIDE
3a,4,7,7a-Tetrahydroisobenzofuran-1,3-dione
Tetrahydroftalanhydrid
Rikacid TH
3a,4,7,7a-Tetrahydro-2-benzofuran-1,3-dione
Tetrahydrophthalic acid anhydride
1,3-Isobenzofurandione, 3a,4,7,7a-tetrahydro-
Memtetrahydro phtalic anhydride
THPA
4-Cyclohexene-1,2-dicarboxylic acid anhydride
4-Cyclohexene-1,2-dicarboxylic anhydride
Anhydrid kyseliny tetrahydroftalove
1,2,3,6-Tetrahydrophthalic acid anhydride
1,3-Isobenzofurandione, tetrahydro-
NSC 82642
Tetrahydroftalanhydrid [Czech]
HSDB 846
Phthalic anhydride, 1,2,3,6-tetrahydro-
EINECS 201-605-4
EINECS 247-570-9
delta(4)-Tetrahydrophthalic anhydride
BRN 0082340
delta(sup 4)-Tetrahydrophthalic anhydride
delta-(sup4)-Tetrahydrophthalic anhydride
DTXSID3026516
1,3,3a,4,7,7a-hexahydro-2-benzofuran-1,3-dione
AI3-22626
Anhydrid kyseliny tetrahydroftalove [Czech]
Tetrahydrophthalsaeureanhydrid
DTXCID306516
CHEBI:180650
EC 201-605-4
5-17-11-00134 (Beilstein Handbook Reference)
MFCD00065335
26266-63-7
Rikacid THPA
Tetrahydrophthalic Anhydride(THPA);3a,4,7,7a-Tetrahydroisobenzofuran-1,3-dione;3a,4,7,7a-Tetrahydroisobenzofuran-1,3-dione
UN2698
3a,4,7,7a-tetrahydro-1,3-isobenzofurandione
4,7,3a,7a-tetrahydroisobenzofuran-1,3-dione
4-Cyclohexene-1, trans-
Tetrahydrophthalic anhydrides
CHEMBL8001
NCIOpen2_001003
(3aR,7aS)-rel-3a,4,7,7a-tetrahydroisobenzofuran-1,3-dione
UN 2698 (Salt/Mix)
SCHEMBL169100
WLN: T56 BVOV GUTJ
3a,4,7,7a-Tetrahydro-isobenzofuran-1,3-dione
Butadienemaleic anhydride adduct
1, 3a,4,7,7a-tetrahydro-
1,3,6-Tetrahydrophthalic anhydride
BCA26823
NSC82642
PDA61423
delta(4)Tetrahydrophthalic anhydride
Tox21_202210
1,2,3,6tetrahydrophthalic anhydride
BBL011743
NSC292900
STL163382
4Cyclohexene1,2dicarboxylic anhydride
.DELTA.4-Tetrahydrophthalic anhydride
AKOS000119224
AKOS016352935
cyclohexene-4,5-dicarboxylic anhydride
Phthalic anhydride,2,3,6-tetrahydro-
.delta.-4-Tetrahydrophthalic anhydride
CS-W019332
delta(sup4)Tetrahydrophthalic anhydride
NSC-292900
1, 3a,4,7,7a-tetrahydro-, trans-
CAS-85-43-8
cis-DELTA4-Tetrahydrophthalic Anhydride
delta(sup 4)Tetrahydrophthalic anhydride
Phthalic anhydride, 1,2,3,6tetrahydro
1,3,6-Tetrahydrophthalic acid anhydride
NCGC00249188-01
NCGC00259759-01
1,2,3,6Tetrahydrophthalic acid anhydride
AC-19634
DELTA1-TETRAHYDROPHTHALIC ANHYDRIDE
DELTA4-TETRAHYDROPHTHALIC ANHYDRIDE
FT157585
trans-1,3,6-Tetrahydrophthalic anhydride
4Cyclohexene1,2dicarboxylic acid anhydride
DB-050508
DB-057412
.delta.-(sup4)-Tetrahydrophthalic anhydride
1,3Isobenzofurandione, 3a,4,7,7atetrahydro
NS00008366
1-cyclohexene-1,2-dicarboxylic acid anhydride
EN300-18012
Cyclohex-4-en-1,2-dicarboxylic acid anhydride
D77853
3a,4,7,7a-Tetrahydro-2-benzofuran-1,3-dione #
AB-131/40207535
CYCLOHEX-4-EN-1,2-DICARBOXYLIC ANHYDRIDE
Q26840954
F0001-2250
(3Ar,7ar)-3a,4,7,7a-tetrahydroisobenzofuran-1,3-dione
1-CYCLOHEXENE-1,2-DICARBOXYLIC ACID, CYCLIC ANHYDRIDE
4-CYCLOHEXENE-1,2-DICARBOXYLIC ACID ANHYDRIDE (CIS)
1,2,3,6-Tetrahydrophthalic anhydride;1,2,3,6-Tetrahydrophthalic anhydride, 4-Cyclohexene-1,2-dicarboxylic anhydride
201-605-4
247-570-9