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Tenofovir Disoproxil

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Identification
Molecular formula
C19H30N5O10P
CAS number
201341-05-1
IUPAC name
[(3aR,4R,6R,6aR)-4-[6-(butanoylamino)purin-9-yl]-2-hydroxy-2-oxo-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-6-yl]methyl butanoate
State
State

In its drug formulation, Tenofovir Disoproxil is typically found as a solid tablet meant for oral consumption.

Melting point (Celsius)
115.00
Melting point (Kelvin)
388.15
Boiling point (Celsius)
610.00
Boiling point (Kelvin)
883.15
General information
Molecular weight
519.40g/mol
Molar mass
519.3960g/mol
Density
1.2878g/cm3
Appearence

Tenofovir Disoproxil is a white to off-white crystalline powder that is hygroscopic in nature. It usually manifests in the form of tablets when used in pharmaceutical applications.

Comment on solubility

Solubility of [(3aR,4R,6R,6aR)-4-[6-(butanoylamino)purin-9-yl]-2-hydroxy-2-oxo-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-6-yl]methyl butanoate

The solubility of the compound [(3aR,4R,6R,6aR)-4-[6-(butanoylamino)purin-9-yl]-2-hydroxy-2-oxo-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-6-yl]methyl butanoate varies based on several factors, making it an interesting subject for study. Here are some key points regarding its solubility:

  • Polarity: The presence of various functional groups can significantly influence the polarity of the compound, thereby affecting its solubility in polar or non-polar solvents.
  • Hydrogen Bonding: The functional groups may enable or hinder hydrogen bonding with solvent molecules, impacting solubility in water.
  • Solvent Interaction: The compound’s interaction with potential solvents—such as water, ethanol, or other organic solvents—can vary widely. For instance, a soluble compound in one solvent may not exhibit the same behavior in another.
  • Temperature Effects: Solubility can also change with temperature; increasing temperature often increases solubility for solid solutes.
  • Concentration Considerations: At higher concentrations, solubility limits may be reached, resulting in precipitation and impacting the compound’s bioavailability.

In summary, the solubility behavior of this compound is influenced by multiple factors, and understanding these can be crucial for applications in drug formulation and chemical analysis. As noted, solubility is not a simplistic concept, but rather a complex interplay of properties that can make a significant difference in practical usage.

Interesting facts

Interesting Facts about 4-(6-(Butanoylamino)purin-9-yl) Derivative

The compound known as (3aR,4R,6R,6aR)-4-[6-(butanoylamino)purin-9-yl]-2-hydroxy-2-oxo-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-6-yl]methyl butanoate is a fascinating molecule that holds significant promise in the field of pharmaceutical chemistry. Below are some intriguing aspects of this compound:

  • Biomedical Relevance: Due to its structure, this compound may play a role in the development of new therapeutic agents aimed at treating various diseases, possibly including cancer and viral infections.
  • Complex Structure: The intricate arrangement of functional groups and the presence of a purine base in its moiety showcase the compound's potential as a nucleoside analog, which is vital in drug design.
  • Phospholane Ring System: The unique tetrahydrofuro and dioxaphospholane ring systems contribute to the compound's stability and reactivity, making it a candidate for further enzymatic studies.
  • Synthetic Pathways: This compound can be synthesized through various methods involving phosphoramide or phosphoric acid derivatives, showcasing the skills needed in synthetic organic chemistry.
  • Research Implications: The presence of the butanoylamino group suggests potential for the build-up of lipophilicity, influencing how the compound interacts with biological membranes, an important factor in drug efficacy.

In conclusion, this compound stands out not just for its potential applications but also for its intricate chemical design that may inspire future research in medicinal chemistry. As one researcher put it, "The beauty of chemistry lies in its ability to create complex solutions to simple problems." This compound represents a prime example of that philosophy.