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Physostigmine sulfate

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Identification
Molecular formula
C17H21N3O2·H2SO4
CAS number
57-47-6
IUPAC name
[(3aS,8bS)-3,4,8b-trimethyl-1,2,3,3a-tetrahydropyrrolo[2,3-b]indol-3-ium-7-yl] N-methylcarbamate;sulfate
State
State

The compound is typically in a solid state at room temperature. It usually exists as its sulfate salt form, which enhances its water solubility and stability.

Melting point (Celsius)
140.00
Melting point (Kelvin)
413.15
Boiling point (Celsius)
974.20
Boiling point (Kelvin)
1 247.35
General information
Molecular weight
413.49g/mol
Molar mass
413.4910g/mol
Density
1.3600g/cm3
Appearence

Physostigmine sulfate appears as a white or slightly yellow crystalline powder. It is odorless but may develop a slight odor upon exposure to air. The compound is soluble in water and alcohol, but insoluble in ether.

Comment on solubility

Solubility of [(3aS,8bS)-3,4,8b-trimethyl-1,2,3,3a-tetrahydropyrrolo[2,3-b]indol-3-ium-7-yl] N-methylcarbamate; sulfate

The solubility of the compound [(3aS,8bS)-3,4,8b-trimethyl-1,2,3,3a-tetrahydropyrrolo[2,3-b]indol-3-ium-7-yl] N-methylcarbamate; sulfate (C17H21N3O2·H2SO4) can be influenced by various factors. Understanding its solubility is crucial for applications in pharmaceuticals and organic chemistry.

Factors Affecting Solubility

  • Polarity: This compound has both polar and non-polar characteristics due to the presence of functional groups such as N-methylcarbamate and sulfate. Generally, compounds are more soluble in solvents that share similar polarity.
  • Temperature: The solubility may vary with temperature; many compounds become more soluble in warmer solvents.
  • pH Levels: As a salt derived from a weak base and a strong acid, the solubility may also change when in acidic or basic environments.

It is often observed that:

  1. Compounds with sulfate ions tend to be more soluble in water due to the highly soluble nature of sulfate salts.
  2. This characteristic is further enhanced if the compound forms stable ion pairs in solution.

In conclusion, while the exact solubility of [(3aS,8bS)-3,4,8b-trimethyl-1,2,3,3a-tetrahydropyrrolo[2,3-b]indol-3-ium-7-yl] N-methylcarbamate; sulfate requires empirical data, understanding its molecular structure and environmental interactions provides valuable insight into its solubility behaviors.

Interesting facts

Interesting Facts about [(3aS,8bS)-3,4,8b-trimethyl-1,2,3,3a-tetrahydropyrrolo[2,3-b]indol-3-ium-7-yl] N-methylcarbamate; sulfate

This unique compound is a fascinating member of the chemical class known as carbamates. Here are some intriguing aspects to consider:

  • Structural Complexity: The compound features a highly complex structure with multiple chiral centers, which can lead to interesting stereochemical properties. Such complexity showcases the rich variety of configurations possible in organic chemistry.
  • Biological Relevance: Compounds derived from the indole family often play significant roles in biological systems. The presence of this compound's segments may indicate potential biological activity worth exploring in fields like pharmacology or natural product chemistry.
  • Potential Applications: Products containing carbamate moieties are often studied for their beneficial properties, including their uses as insecticides, herbicides, and in various therapeutic applications. Understanding this compound could lead to new discoveries in such areas.
  • Interdisciplinary Connections: The interplay between organic synthesis and medicinal chemistry is evident in the study of such compounds. This connection emphasizes the engaging nature of modern chemical research, as discoveries often transcend traditional boundaries.
  • Historical Significance: The study of carbamates has been pivotal in the development of numerous agrochemicals and pharmaceuticals. By delving into this compound, researchers continue the legacy of pioneering scientists who have contributed to our understanding of chemical compounds and their impacts on society.

As you explore this compound further, consider the profound implications its structure may have on its reactivity and interactions. The combination of intricate chemical frameworks coupled with potential biological activity showcases the importance of continuous research in the field of chemistry.

Synonyms
Eserine sulphate
Physostigmine SO4
PHYSOSTIGMINE SULFATE
Physostigmine sulphate
Physostigmine hemisulfate
EINECS 200-585-4
UNII-G63V2J2N71
Physostigmine sulfate [USP]
G63V2J2N71
Pyrrolo(2,3-b)indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS,8aR)-, sulfate (2:1) (salt)
Pyrrolo(2,3-b)indole, 1,2,3,3a,8,8a-hexahydro-5-hydroxy-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS-cis)-, sulfate (2:1)
Pyrrolo(2,3-b)indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS-cis)-, sulfate (2:1)
Pyrrolo(2,3-b)indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, 5-(N-methylcarbamate), (3aS,8aR)-, sulfate (2:1)