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Benzimidazol-5-amine

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Identification
Molecular formula
C7H7N3
CAS number
1093281-82-0
IUPAC name
3H-benzimidazol-5-amine
State
State

At room temperature, benzimidazol-5-amine is in a solid state, presenting as a crystalline powder.

Melting point (Celsius)
194.00
Melting point (Kelvin)
467.15
Boiling point (Celsius)
302.00
Boiling point (Kelvin)
575.15
General information
Molecular weight
133.16g/mol
Molar mass
133.1580g/mol
Density
1.2800g/cm3
Appearence

Benzimidazol-5-amine typically appears as a white to slightly beige crystalline powder. It may vary slightly depending on purity.

Comment on solubility

Solubility of 3H-benzimidazol-5-amine

The solubility of 3H-benzimidazol-5-amine is quite intriguing and can be influenced by several factors. This compound is known to exhibit varying solubility characteristics based on its environment:

  • Solvent Type: Generally, 3H-benzimidazol-5-amine is more soluble in polar solvents like water and methanol compared to non-polar solvents such as hexane.
  • pH Dependence: The solubility can also change with the pH of the solution; it tends to increase in acidic conditions due to protonation.
  • Temperature Effects: An increase in temperature often enhances solubility, allowing for a greater amount of 3H-benzimidazol-5-amine to dissolve in solvents.

In practice, the solubility of this compound can be described as:

  1. Moderately Soluble: In aqueous solutions at room temperature.
  2. High Solubility: When subjected to heating or mixing with appropriate polar solvents.

It is crucial to consider these factors when working with 3H-benzimidazol-5-amine to maximize its utility in various applications, as "solubility is the key to accessibility." Understanding the solubility profile helps in predicting behavior in biochemical assays, pharmaceutical formulations, and chemical reactions.

Interesting facts

Interesting Facts about 3H-benzimidazol-5-amine

3H-benzimidazol-5-amine, also known as a derivative of the benzimidazole class of compounds, exhibits a variety of fascinating properties and applications that ignite the curiosity of both chemists and students alike. Here are some intriguing points about this compound:

  • Pharmaceutical Potential: 3H-benzimidazol-5-amine has gained attention for its role in numerous pharmaceutical applications. It serves as a scaffold for developing new drugs, particularly those targeting gastrointestinal disorders and cancer.
  • Biological Activity: Studies have reported that benzimidazole derivatives, including 3H-benzimidazol-5-amine, possess a range of biological activities, including anti-parasitic and anti-inflammatory effects. This makes them valuable in medicinal chemistry.
  • Versatile Intermediates: The structure of 3H-benzimidazol-5-amine provides a versatile platform for further chemical modifications. Researchers often modify its structure to create derivatives with enhanced potency or different pharmacological profiles.
  • Role in Material Science: Beyond its medicinal uses, this compound plays a role in material science. Its unique structure allows it to be incorporated into various materials, potentially altering their properties for specific applications.
  • Historical Significance: The benzimidazole class itself has a rich history in chemistry, dating back to the early 20th century. Discoveries involving benzimidazole derivatives have paved the way for numerous innovations in both chemistry and medicine.

As the search for novel therapeutic agents continues, compounds like 3H-benzimidazol-5-amine highlight the incredible potential of chemistry in transforming healthcare and advancing material innovation. In the words of renowned chemist Linus Pauling, "Chemistry is the science of connection," and this compound serves as a prime example of the connections that lead to groundbreaking discoveries.

Synonyms
5-Aminobenzimidazole
934-22-5
6-Aminobenzimidazole
1H-Benzimidazol-5-amine
1H-Benzimidazol-6-amine
BENZIMIDAZOLE, 5-AMINO-
Benzimidazole, 6-amino-
Benzimidazol-5-amine
1H-benzimidazol-5-ylamine
EINECS 213-279-0
NSC 231612
UNII-7L7289019S
NSC-231612
3H-benzo[d]imidazol-5-amine
AMINOBENZIMIDAZOLE, 5-
7L7289019S
DTXSID70239406
3H-BENZO(D)IMIDAZOL-5-AMINE
BENZIMIDAZOLE, 5(OR 6)-AMINO-
1H-Benzimidazol-5-amine (9CI)
DTXCID50161897
213-279-0
wfrxsxudwcvspi-uhfffaoysa-n
1H-Benzo[d]imidazol-6-amine
55299-95-1
1H-Benzoimidazol-5-ylamine
1h-benzo[d]imidazol-5-amine
3H-benzimidazol-5-amine
3H-BENZOIMIDAZOL-5-YLAMINE
1h-1,3-benzimidazol-5-amine
1H-1,3-benzodiazol-5-amine
1H-1,3-benzodiazol-6-amine
1H-benzimidazol-5-amine dihydrochloride
CHEMBL1617811
MFCD00831692
Benzimidazol-5-ylamine
5-amino-1h-benzimidazole
5-AMINO-1H-BENZOIMIDAZOLE
5-aminobenzimdazole
5-aminobenzimidazol
MFCD00465258
5-amino benzimidazole
5-amino-benzimidazole
1H-benzimidazole-6-amine
1H-benzoimidazol-5-amine
6-Amino-1H-benzimidazole
3H-benzimidazol-5-ylamine
6-Aminobenzimidazole, 95%
1H-Benzimidazol-6-amine #
Oprea1_342288
Oprea1_610116
(1H-benzimidazol-5yl) amine
SCHEMBL115965
5-amino-1H-benzo[d]imidazole
5-aminobenzimidazole, AldrichCPR
ALBB-023267
BCP11467
BBL011727
BDBM50455561
NSC231612
STK731665
AKOS000111798
AKOS003574217
1H-1 pound not3-Benzimidazol-5-amine
AC-2803
PS-4509
NCGC00184564-01
NCGC00184564-02
SY002960
A2605
CS-0096864
NS00039556
EN300-57442
2P-043
F11742
AH-034/32844026
Q27268505
F2158-1066
Z1741960823