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Indole-2-thiol

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Identification
Molecular formula
C8H7NS
CAS number
1450-77-1
IUPAC name
3H-indole-2-thiol
State
State

At room temperature, indole-2-thiol is typically found in a solid-state, often as a powder or crystalline form.

Melting point (Celsius)
159.00
Melting point (Kelvin)
432.15
Boiling point (Celsius)
364.00
Boiling point (Kelvin)
637.15
General information
Molecular weight
149.21g/mol
Molar mass
149.2140g/mol
Density
1.2600g/cm3
Appearence

Indole-2-thiol is typically a yellow to tan crystalline solid. The compound may also appear as powder and can have a characteristic odor.

Comment on solubility

Solubility of 3H-indole-2-thiol

3H-indole-2-thiol, a compound featuring both indole and thiol functional groups, presents intriguing solubility characteristics that are influenced by its molecular structure. Here are some key points regarding its solubility:

  • Polarity: The presence of the thiol group (-SH) enhances polarity, promoting solubility in polar solvents.
  • Aqueous Solubility: 3H-indole-2-thiol has limited solubility in water due to the hydrophobic nature of the indole ring. However, it may exhibit increased solubility in aqueous solutions when accompanied by salts or in the presence of pH modifiers.
  • Organic Solvents: It is generally more soluble in organic solvents such as ethanol, methanol, and acetone, where the interactions between the solute and solvent molecules can stabilize the compound.
  • Solvent Effects: The choice of solvent can greatly affect the solubility; thus, selecting an appropriate solvent is crucial for experiments or applications involving 3H-indole-2-thiol.

Overall, understanding the solubility of 3H-indole-2-thiol can be crucial for its application in various chemical and biochemical contexts. As noted, "the solubility behavior is often dictated by molecular design," making it essential to consider both the solvent properties and the compound's functional groups.

Interesting facts

Exploring 3H-Indole-2-thiol

3H-Indole-2-thiol is an intriguing organic compound that belongs to the indole family, known for its diverse range of biological activities and applications. Here are some interesting facts about this unique compound:

  • Structure Significance: The thiol (-SH) group in 3H-Indole-2-thiol plays a crucial role in its reactivity and function. Thiols are known for their ability to form disulfide bonds, which are essential in various biochemical processes.
  • Biological Activity: Compounds containing indole motifs, like 3H-indole-2-thiol, are frequently found in nature. They exhibit a wide range of biological properties, including anti-inflammatory and antimicrobial activities, making them a point of interest in medicinal chemistry.
  • Role in Biology: The indole structure is integral to many natural products, including tryptophan and various alkaloids. This connection highlights the compound's potential importance in life sciences and its role in synthesizing important biomolecules.
  • Research Potential: Ongoing research explores the applications of 3H-Indole-2-thiol in the development of drugs and therapeutic agents. Its unique reactivity makes it a target for synthesis in pharmacology, particularly in compounds aimed at targeting specific biological pathways.
  • Colorimetric Properties: Some studies have highlighted the ability of 3H-Indole-2-thiol to act as a chromogenic reagent, which can be harnessed for analytical applications in chemical sensing and detection.

In conclusion, 3H-Indole-2-thiol is more than just a chemical compound; it represents a bridge between chemistry, biology, and medicine. Its versatile properties and natural occurrence underline the interconnectedness of chemical science and biological function.