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Phthalide

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Identification
Molecular formula
C8H6O2
CAS number
87-41-2
IUPAC name
3H-isobenzofuran-1-one
State
State
Solid at room temperature.
Melting point (Celsius)
72.00
Melting point (Kelvin)
345.15
Boiling point (Celsius)
290.00
Boiling point (Kelvin)
563.15
General information
Molecular weight
134.14g/mol
Molar mass
134.1370g/mol
Density
1.1993g/cm3
Appearence

Phthalide is a white crystalline solid that may appear as needles or flakes. It is often used in the synthesis of various pharmaceuticals and is valued for its aromatic properties.

Comment on solubility

Solubility of 3H-isobenzofuran-1-one

The solubility of 3H-isobenzofuran-1-one, also known as isobenzofuranone, can be quite intriguing as it demonstrates characteristics typical of similar aromatic compounds. This compound is moderately soluble in a variety of solvents, which can be attributed to its unique structure.

Solubility Characteristics:

  • Polar Solvents: 3H-isobenzofuran-1-one shows better solubility in polar solvents such as methanol and dimethyl sulfoxide (DMSO), attributed to possible hydrogen bonding interactions.
  • Non-Polar Solvents: It exhibits limited solubility in non-polar solvents like hexane, indicating its aromatic nature and the influence of π-π stacking interactions among molecules.
  • pH Influence: The solubility can also be influenced by the pH of the solution, with increased solubility in more acidic environments.

In general, the solubility of 3H-isobenzofuran-1-one is characterized by its interactions with different solvents, making its application dependent on the solvent choice. As noted by chemists, understanding these solubility behaviors becomes crucial in further applications, particularly in synthesis and extraction processes.

Interesting facts

Exploring 3H-isobenzofuran-1-one

3H-isobenzofuran-1-one, also known as isobenzofuran-1-one, is a fascinating compound belonging to the family of heterocyclic organic chemicals. This compound is notable for its unique structure and properties, which have intrigued scientists and chemists alike.

Key Characteristics

  • Structure: The isobenzofuran skeleton comprises a fused aromatic and heterocyclic ring, offering enhanced stability and reactivity.
  • Reactivity: With its electrophilic nature, 3H-isobenzofuran-1-one participates in a variety of chemical reactions, making it valuable in organic synthesis.
  • Applications: This compound serves as an intermediate in the production of pharmaceuticals, agrochemicals, and dyes, showcasing its versatility in different fields.
  • Biological Activity: Several derivatives of 3H-isobenzofuran-1-one exhibit interesting biological activities, positioning them as potential candidates in drug discovery.

Importance in Research

Due to its distinct characteristics, 3H-isobenzofuran-1-one is often a subject of research in organic chemistry. As noted by researchers, "the exploration of heterocyclic structures can lead to the discovery of new pharmacologically active substances." This perspective highlights the potential of compounds like 3H-isobenzofuran-1-one in advancing medicinal chemistry.

In summary, 3H-isobenzofuran-1-one not only contributes to the vast landscape of organic compounds but also serves as a stepping stone towards innovative research and applications in various scientific disciplines.

Synonyms
PHTHALIDE
87-41-2
Isobenzofuran-1(3H)-one
2-Benzofuran-1(3H)-one
1-Phthalanone
1(3H)-Isobenzofuranone
Phthalolactone
3H-2-benzofuran-1-one
3H-isobenzofuran-1-one
Isobenzofuranone
1-Isobenzofuranone
Phthalanone
1,3-dihydro-2-benzofuran-1-one
MFCD00005906
CCRIS 3598
CHEBI:38085
2-Hydroxymethylbenzoic acid, gamma-lactone
NSC 1469
EINECS 201-744-0
UNII-8VV922U86J
BRN 0114632
DTXSID0052594
AI3-05785
8VV922U86J
NSC-1469
PHTHALIDE [FHFI]
2-Hydroxymethylbenzoic acid, .gamma.-lactone
CHEMBL2391738
DTXCID7031167
FEMA NO. 4195
EC 201-744-0
5-17-10-00007 (Beilstein Handbook Reference)
Phthalide, 98%
1Phthalanone
1Isobenzofuranone
isobenzofuran-1-one
591234-45-6
(3H)-isobenzofuranone
1(3H)Isobenzofuranone
1H-Isobenzofuran-3-one
Butylphthalide Impurity 4
isobenzofuran-1 (3H)-one
SCHEMBL22284
2-benzofuran-1(3 H)-one
Phthalide, analytical standard
2-Benzofuran-1(3H)-one #
F1172-0018
CHLORTALIDONE IMPURITY 7
3-oxo-1,3-dihydro-isobenzofuran
NSC1469
2-Hydroxymethylbenzoate, g-lactone
HMS1625A13
2-Hydroxymethylbenzoate, I3-lactone
Tox21_303762
BDBM50491969
STK802334
2-Hydroxymethylbenzoate, gamma-lactone
AKOS000121167
2-Hydroxymethylbenzoic acid, g-lactone
CS-W016536
HY-W015820
2Hydroxymethylbenzoic acid, gammalactone
CAS-87-41-2
2-Hydroxymethylbenzoic acid, I3-lactone
NCGC00357058-01
DA-76838
SY001701
DB-072577
NS00008646
P0401
EN300-25532
A26520
AE-641/30105043
Q7188203
2-Hydroxymethylbenzoic acid, laquo gammaRaquo -lactone
2-Hydroxymethylbenzoic acid, laquo gammaraquo-lactone
4,5,6,7-Tetrachloro-1(3H)-isobenzofuranone (9CI)
Z211309000
1,3-Dihydrobenzo[C]furan-2-one;2-Benzofuran-1(3H)-one;2-Hydroxymethylbenzoic acid, gamma-lactone;Phthalolactone
201-744-0
608-088-8