Skip to main content

Ropinirole

ADVERTISEMENT
Identification
Molecular formula
C16H23NO
CAS number
91374-20-8
IUPAC name
(3R)-3-(1-benzyl-4-piperidyl)-3-phenyl-piperidine-2,6-dione
State
State

The compound is a solid at room temperature.

Melting point (Celsius)
243.00
Melting point (Kelvin)
516.15
Boiling point (Celsius)
450.00
Boiling point (Kelvin)
723.15
General information
Molecular weight
260.35g/mol
Molar mass
260.3470g/mol
Density
1.2000g/cm3
Appearence

The compound is typically a white to pale-yellow powder.

Comment on solubility

Solubility of (3R)-3-(1-benzyl-4-piperidyl)-3-phenyl-piperidine-2,6-dione

The solubility of the compound (3R)-3-(1-benzyl-4-piperidyl)-3-phenyl-piperidine-2,6-dione is a crucial aspect to consider in its application and usage. This compound features multiple functional groups that can influence its solubility profile significantly.

Factors Affecting Solubility:

  • Polarity: The presence of aromatic rings and nitrogen atoms can create polar regions, which might enhance solubility in polar solvents.
  • Hydrogen Bonding: The compound's ability to form hydrogen bonds can increase its solubility in protic solvents, like water and alcohols.
  • Molecular Weight: Having a reasonably high molecular weight can complicate solubility, especially in less polar solvents.

“Solubility is not just about being dissolved; it’s about interactions at the molecular level.” With the given structure, we can anticipate:

  • Potential moderate solubility in organic solvents such as ethanol and DMSO.
  • Limited solubility in water due to its complex structure, which might resist full dissociation.

In conclusion, to fully assess the solubility of (3R)-3-(1-benzyl-4-piperidyl)-3-phenyl-piperidine-2,6-dione, empirical studies would be necessary. Understanding the solubility in various solvents can aid in selecting appropriate reaction conditions and applications for this compound.

Interesting facts

Interesting Facts about (3R)-3-(1-benzyl-4-piperidyl)-3-phenyl-piperidine-2,6-dione

This compound is a fascinating member of the piperidine family, a class known for its significant pharmacological properties. Here are some interesting aspects:

  • Structure and Chirality: The presence of chirality in this compound is pivotal, as it contributes to the specific biological activity it exhibits. The (3R) configuration indicates that the molecule has a particular spatial arrangement that can affect its interaction with biological targets such as receptors.
  • Potential Applications: Compounds like this have been investigated for their potential use in treating neurological disorders. The conformational ability of piperidine derivatives gives them a versatile profile that can be tuned for various therapeutic effects.
  • Synthesis Insights: The synthesis of this compound involves multi-step organic reactions, highlighting the beauty and complexity of organic chemistry. Techniques such as asymmetric synthesis may play a critical role in producing the desired stereoisomer.
  • Interdisciplinary Connections: The study of such compounds often bridges disciplines, involving medicinal chemistry, pharmacology, and even computational chemistry to predict interactions at a molecular level.
  • Historical Context: Piperidine derivatives have a rich history in medicinal chemistry, tracing back to their early use in alkaloid-based medications. This compound continues that legacy, showcasing the evolution of drug discovery.

Overall, (3R)-3-(1-benzyl-4-piperidyl)-3-phenyl-piperidine-2,6-dione exemplifies the intricate relationship between chemical structure and biological function that is at the heart of modern chemistry. As researchers delve deeper, they may unlock further secrets and applications of this intriguing compound.

Synonyms
Levetimide
21888-99-3
l-Benzetimide
(-)-Benzetimide
576087I4XG
Glutarimide, 2-(1-benzyl-4-piperidyl)-2-phenyl-, (-)-
DTXSID401183493
(3,4'-Bipiperidine)-2,6-dione, 3-phenyl-1'-(phenylmethyl)-, (R)-
(3R)-3-phenyl-3-(1-(phenylmethyl)piperidin-4-yl)piperidine-2,6-dione
(3R)-3-phenyl-3-[1-(phenylmethyl)piperidin-4-yl]piperidine-2,6-dione
RefChem:906023
DTXCID701614831
(3R)-3-Phenyl-1'-(phenylmethyl)(3,4'-bipiperidine)-2,6-dione
[3,4'-Bipiperidine]-2,6-dione, 3-phenyl-1'-(phenylmethyl)-, (3R)-
(R)-1'-benzyl-3-phenyl-[3,4'-bipiperidine]-2,6-dione
(3R)-3-(1-benzylpiperidin-4-yl)-3-phenylpiperidine-2,6-dione
laevo-Benzetimide
(3,4'-BIPIPERIDINE)-2,6-DIONE, 3-PHENYL-1'-(PHENYLMETHYL)-, (3R)-
BRN 6490018
1''-Benzyl-3-phenyl-[3,4'']bipiperidinyl-2,6-dione
BENZETIMIDE, (R)-
GTPL358
CHEMBL273974
SCHEMBL1651291
UNII-576087I4XG
BDBM50018550
PDSP1_001834
PDSP2_001817
AKOS040741945
HY-105545A
DA-64935
MS-25763
CS-0068505
G13375
Q27080260
R(-)-LEVETIMIDE HYDROCHLORIDE (R47210) M USACARIN
(3R)-3-(1-benzyl-4-piperidyl)-3-phenyl-piperidine-2,6-dione
(3R)-3-Phenyl-1a(2)-(phenylmethyl)[3,4a(2)-bipiperidine]-2,6-dione
[3,4 inverted exclamation marka-Bipiperidine]-2,6-dione, 3-phenyl-1 inverted exclamation marka-(phenylmethyl)-, (3R)-