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Vancomycin

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Identification
Molecular formula
C66H75Cl2N9O24
CAS number
1404-90-6
IUPAC name
[(3R,4S,5R,6R)-5-hydroxy-6-[2-hydroxy-3-[[4-hydroxy-3-(3-methylbut-2-enyl)benzoyl]amino]-8-methyl-4-oxo-chromen-7-yl]oxy-3-methoxy-2,2-dimethyl-tetrahydropyran-4-yl] carbamate
State
State

Vancomycin is typically a solid at room temperature. It is often provided in a powdered form for reconstitution when used in pharmaceutical applications, particularly for injection or infusion purposes.

Melting point (Celsius)
155.00
Melting point (Kelvin)
428.15
Boiling point (Celsius)
700.00
Boiling point (Kelvin)
973.15
General information
Molecular weight
1449.30g/mol
Molar mass
1 449.3000g/mol
Density
1.1650g/cm3
Appearence
Vancomycin typically appears as a white or off-white crystalline powder. It is known for its characteristic role as an antibiotic, primarily used in its hydrochloride form for medical applications. It is hygroscopic and should be stored in a tightly closed container to prevent moisture uptake from the atmosphere.
Comment on solubility

Solubility of the Compound

The solubility of the compound, [(3R,4S,5R,6R)-5-hydroxy-6-[2-hydroxy-3-[[4-hydroxy-3-(3-methylbut-2-enyl)benzoyl]amino]-8-methyl-4-oxo-chromen-7-yl]oxy-3-methoxy-2,2-dimethyl-tetrahydropyran-4-yl] carbamate, can be understood through various factors:

  • Solvent Interaction: The presence of multiple hydroxyl groups and a carbamate functionality suggests that this compound may have the ability to form hydrogen bonds with polar solvents, potentially enhancing its solubility in water.
  • Hydrophobic Regions: The **alkyl and aromatic portions** of the compound may exhibit hydrophobic characteristics, which could limit its solubility in aqueous solutions, indicating that solubility may vary significantly in organic solvents.
  • pH Dependence: The ionization state of the compound can change with pH levels, influencing its solubility. For instance, at higher pH levels, it could be more soluble due to deprotonation of acidic groups.
  • Concentration Dynamics: Solubility may also depend on concentration. As a compound is dissolved, saturation points could restrict further dissolving, leading to complex behavior in solution.

In summary, while the presence of functional groups propelling polar interactions suggests reasonable aqueous solubility, the overall solubility characteristics are likely constrained by hydrophobic segments and pH interactions. Therefore, comprehensive experimentation to determine precise solubility metrics in various solvents will be essential for practical applications.

Interesting facts

Interesting Facts about the Compound

The compound you are inquiring about is a fascinating example of the complexity found in organic chemistry. This particular entity is a derivative of flavonoids, a class of compounds known for their diverse biological activities. Here are several intriguing aspects:

  • Bioactivity: Many flavonoid derivatives exhibit significant biological properties, including antioxidant, anti-inflammatory, and anticancer activities. The intricate structure of this compound suggests potential applications in pharmacology and medicinal chemistry.
  • Synthetic Pathways: The synthesis of compounds with such complex architectures often involves multi-step reactions. This can include processes such as coupling reactions, protection and deprotection strategies, and even the use of transition metal catalysts.
  • Chemical Diversity: The presence of multiple functional groups—such as hydroxy, methoxy, and carbamate—provides an opportunity for diverse chemical reactivity, making this compound a potential candidate for many applications in small molecule synthesis and chemical biology.
  • Natural Products: Many compounds with similar structures are derived from natural sources, particularly plants. The study of natural products is crucial in drug discovery, as they often lead to the development of novel therapeutic agents.
  • Structure-Activity Relationship (SAR): The structural nuances of this compound, such as its stereochemistry and the positioning of functional groups, can significantly influence its biological activity and interaction with biological targets.

In conclusion, the depth of study surrounding such a compound is vast and varied. As a chemistry student or researcher, one must appreciate the inherent complexities and potential applications that lie within the world of organic compounds.