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Halichondrin B

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Identification
Molecular formula
C56H92O15
CAS number
11011-38-4
IUPAC name
(3R,4S,6S,8S,10R,12R,14R,16S,27S,28R)-4,6,8,10,12,14,16,27-octahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one
State
State
Halichondrin B is generally found as a crystalline solid at room temperature. It is isolated from certain marine sponges and typically requires specific storage conditions to maintain its stability.
Melting point (Celsius)
70.00
Melting point (Kelvin)
343.00
Boiling point (Celsius)
77.00
Boiling point (Kelvin)
350.00
General information
Molecular weight
1111.36g/mol
Molar mass
1 111.3620g/mol
Density
1.3200g/cm3
Appearence

Halichondrin B is a large, complex molecule that appears as a white solid at room temperature. It is typically isolated from natural sources and thus may sometimes be encountered as part of a crude extract, influencing its appearance slightly depending on extraction methods.

Comment on solubility

Solubility of (3R,4S,6S,8S,10R,12R,14R,16S,27S,28R)-4,6,8,10,12,14,16,27-octahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one

The solubility of this complex organic compound can be influenced by various factors, including its structural characteristics and functional groups present. In general, the presence of multiple hydroxyl groups (-OH) typically enhances solubility in polar solvents such as water due to hydrogen bonding. However, the large hydrophobic tail from the hexyl and methyl groups adds a nonpolar character, which can hinder solubility in highly polar environments.

Key considerations regarding solubility include:

  • Hydroxyl Groups: The octahydroxy substitutions suggest increased interaction with polar solvents.
  • Hydrophobic Regions: Methyl groups can result in non-polar characteristics, which may promote solubility in organic solvents like ethanol or acetone.
  • Overall Structure: The overall three-dimensional conformation can affect how the molecule interacts with solvents.

As a general trend, the more polar the solvent, the higher the likelihood of solubility for such a hydroxyl-rich compound, with a potential for solubility in a blend of polar and nonpolar solvents rather than in pure water. This complexity in solubility behavior may lead to it being sparingly soluble in water while being more soluble in organic solvents. Thus, the specific solubility profile should ideally be determined experimentally to assess the extent to which it can dissolve in various solvents.

Interesting facts

Interesting Facts About (3R,4S,6S,8S,10R,12R,14R,16S,27S,28R)-4,6,8,10,12,14,16,27-octahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one

This complex organic compound belongs to a fascinating class of chemicals known for their biological activity. Understanding its structure and properties opens a window to numerous applications in fields like pharmaceuticals and biochemistry. Here are some interesting points to consider:

  • Structural Complexity: With multiple hydroxyl groups and a unique oxacyclooctacosa framework, this compound exhibits remarkable steric and electronic properties that influence its reactivity and interactions.
  • Biological Importance: Compounds of this type often play critical roles in biological systems, acting as signaling molecules or precursors to essential biomolecules.
  • Synthesis Challenges: The synthesis of such a multi-functionalized molecule can be intricate, often requiring advanced techniques in organic chemistry to achieve the desired configurations and stereochemistry.
  • Potential Applications: The unique structure suggests possible uses in drug development, particularly for targeting complex biological pathways or as natural products in medicinal chemistry.
  • Research Potential: Scientists are continually exploring the myriad of properties that such compounds present, making them a vibrant topic of research in search of novel therapeutic agents.

As you delve into the study of (3R,4S,6S,8S,10R,12R,14R,16S,27S,28R)-4,6,8,10,12,14,16,27-octahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one, remember that its intricate structure carries much more than just atoms and bonds; it is a testament to the beauty and complexity of chemical science. From discovery to practical application, the journey of such compounds is always a thrilling endeavor for any chemistry enthusiast.

Synonyms
11078-21-0