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Estradiol

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Identification
Molecular formula
C18H24O2
CAS number
50-28-2
IUPAC name
(3R,5S,17S)-3-methoxy-10,13,17-trimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-ol
State
State

Estradiol is a solid at room temperature. It is not volatile and is typically stable under normal conditions. It is often found in pharmaceutical settings as a fine powder or in tablet form.

Melting point (Celsius)
176.00
Melting point (Kelvin)
449.00
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.00
General information
Molecular weight
272.38g/mol
Molar mass
272.3830g/mol
Density
1.1260g/cm3
Appearence

Estradiol is typically a white to off-white crystalline powder. It is odorless and has a slightly bitter taste. The compound is commonly found in the form of fine crystals or crystalline powder.

Comment on solubility

Solubility of (3R,5S,17S)-3-methoxy-10,13,17-trimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-ol

The solubility of (3R,5S,17S)-3-methoxy-10,13,17-trimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-ol can be influenced by several factors such as its molecular structure, functional groups, and the presence of hydrophobic or hydrophilic characteristics. This compound, with its complex bicyclic structure and multiple methyl groups, may exhibit varying solubility in different solvents. Here are a few aspects worth noting:

  • Solvent Compatibility: Due to its hydrophobic nature, it is likely to be more soluble in organic solvents such as ethanol, chloroform, or acetone.
  • Hydroxyl Group: The presence of the hydroxyl (-OH) group suggests some affinity for polar solvents, potentially enhancing solubility in water under certain conditions, albeit modestly.
  • Temperature Effects: Solubility may increase with temperature, so it is crucial to consider thermal conditions when assessing dissolution properties.

In conclusion, while the specific solubility values for this compound may not be readily available in standard literature, it is clear that careful consideration of its structural features can provide insights into its solubility behaviors. Understanding these factors can facilitate its application in various chemical and pharmaceutical contexts.

Interesting facts

Interesting Facts about (3R,5S,17S)-3-methoxy-10,13,17-trimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-ol

This compound is a fascinating member of the steroid family, known for its complex structure and significant biological activity. Here are some noteworthy aspects that make it particularly interesting:

  • Structural Complexity: The numerous methyl groups and unique stereochemistry contribute to its intricate three-dimensional shape, which is vital for its interactions and functions in biological systems.
  • Natural Occurrence: Compounds similar to this have been isolated from various natural sources, particularly in medicinal plants, highlighting their potential roles in traditional medicine.
  • Biological Significance: Many steroids, including those related to this compound, play critical roles in regulating physiological processes like metabolism, immune response, and sexual development.
  • Potential Pharmacological Applications: Research into compounds with similar structures may lead to the development of new therapeutic agents, particularly in the fields of endocrinology and oncology.
  • Stereochemical Precision: The designation of stereocenters (3R, 5S, 17S) is crucial as even minor changes in stereochemistry can lead to significant alterations in biological activity.

In conclusion, (3R,5S,17S)-3-methoxy-10,13,17-trimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-ol is not just a chemical compound but a key piece in the puzzle of biochemistry that bridges structural chemistry and biological function. Studying such compounds opens avenues for greater understanding and innovation in pharmaceutical sciences.