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Cortisol

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Identification
Molecular formula
C21H30O5
CAS number
50-23-7
IUPAC name
(3R,8S,9S,10R,13S,14S,17R)-3,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,3,6,7,8,9,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-11-one
State
State
Solid at room temperature. Cortisol is typically available as a solid powder or in crystalline form, depending on its preparation and use.
Melting point (Celsius)
215.00
Melting point (Kelvin)
488.15
Boiling point (Celsius)
537.20
Boiling point (Kelvin)
810.35
General information
Molecular weight
362.46g/mol
Molar mass
362.4610g/mol
Density
1.3000g/cm3
Appearence

Cortisol is a white to off-white, odorless, crystalline powder. When purified, it appears as fine crystals or may form a powdery texture, depending on the processing method.

Comment on solubility

Solubility of (3R,8S,9S,10R,13S,14S,17R)-3,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,3,6,7,8,9,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-11-one

The solubility of the compound with the chemical formula C21H30O5 is influenced by several factors, reflecting a degree of complexity owing to its intricate structure. This specific compound, being an organic molecule, exhibits varying solubility characteristics based on its functional groups and overall hydrophobicity. Here are some key points to consider regarding its solubility:

  • Polarity: The presence of hydroxyl (-OH) groups typically increases solubility in polar solvents, such as water, due to hydrogen bonding.
  • Hydrophobic Regions: Despite the polar functional groups, the overall hydrophobic character contributed by the extensive hydrocarbon framework may limit solubility in aqueous environments.
  • Solvent Compatibility: This compound may be more soluble in organic solvents like ethanol, methanol, or dimethyl sulfoxide (DMSO), where the nonpolar components can interact favorably.
  • Temperature Effects: Solubility is often temperature-dependent; increasing the temperature may enhance solubility in certain solvents.

In summary, while the hydroxyl groups suggest potential for solubility in polar solvents, the compound's hydrophobic nature likely leads to limited aqueous solubility. An experimental determination of solubility would be essential to ascertain the exact characteristics of this compound in various solvents.

Interesting facts

Exploring the Compound: (3R,8S,9S,10R,13S,14S,17R)-3,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,3,6,7,8,9,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-11-one

This fascinating compound, often discussed in the context of biochemical research and pharmacology, has an intricate structure with significant biological implications. Here are some engaging insights into this unique molecule:

Key Features

  • Stereochemistry: The compound is characterized by a specific 3D arrangement of atoms, denoted by its chiral centers. This stereochemical configuration plays a crucial role in its biological activity and interactions with receptors in the body.
  • Functional Groups: With both hydroxyl (-OH) and acetyl (-COCH3) groups, it exhibits properties of polar compounds, which could enhance its solubility and activity in biological systems.
  • Class of Compounds: Belonging to the class of steroid-like compounds, it likely shares similarities in behavior and functionality with other steroids, influencing metabolic pathways.

Biological Relevance

Researchers have taken a keen interest in compounds like this due to their potential effects in various biological contexts:

  • Hormonal activity: Similar structures are often involved in hormonal regulation and signaling, making them pertinent to studies in endocrinology.
  • Cancer research: Compounds with steroidal frameworks have been investigated for their roles in cancer therapies, targeting specific pathways that encourage tumor growth.
  • Pharmaceutical development: This complex structure serves as a template or a starting point for the synthesis of new drugs aimed at treating diseases, showcasing the compound's potential in medicinal chemistry.

In summary, the compound (3R,8S,9S,10R,13S,14S,17R)-3,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,3,6,7,8,9,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-11-one is not only intriguing due to its structural complexity but also holds great promise in scientific inquiry, particularly concerning its biological applications and pharmaceutical development.

Synonyms
BDBM50378799