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N-Phenyl-1-benzyl-4-piperidylsuccinimide

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Identification
Molecular formula
C23H26N2O2
CAS number
2888-49-1
IUPAC name
(3S)-3-(1-benzyl-4-piperidyl)-3-phenyl-piperidine-2,6-dione
State
State

This compound is in a solid state at room temperature.

Melting point (Celsius)
167.50
Melting point (Kelvin)
440.65
Boiling point (Celsius)
464.30
Boiling point (Kelvin)
737.45
General information
Molecular weight
338.47g/mol
Molar mass
338.4380g/mol
Density
1.2270g/cm3
Appearence

This compound typically appears as a white to off-white crystalline powder. Its solid form makes it conducive for handling in laboratory conditions and it typically does not have a strong odor.

Comment on solubility

Solubility of (3S)-3-(1-benzyl-4-piperidyl)-3-phenyl-piperidine-2,6-dione

The solubility of the compound (3S)-3-(1-benzyl-4-piperidyl)-3-phenyl-piperidine-2,6-dione can be analyzed based on its chemical structure and functional groups. Here are some important points to consider:

  • Polarity: The presence of multiple functional groups in the compound can influence its overall polarity. Generally, compounds with polar functional groups tend to have higher solubility in polar solvents, while non-polar regions favor solubility in non-polar solvents.
  • Hydrogen Bonding: The ability of the compound to participate in hydrogen bonding plays a crucial role in its solubility. If the compound can form hydrogen bonds with the solvent molecules, its solubility is likely to increase.
  • Aromaticity: The benzyl and phenyl groups introduce non-polar characteristics, which may decrease solubility in polar solvents but increase solubility in organic solvents.
  • Temperature Effects: As with many organic compounds, solubility can vary with temperature. Typically, solubility increases with an increase in temperature.
  • Common Solvents: Preliminary studies suggest that this compound may show better solubility in organic solvents such as ethanol or dimethyl sulfoxide (DMSO) compared to water.

In summary, the solubility of (3S)-3-(1-benzyl-4-piperidyl)-3-phenyl-piperidine-2,6-dione is influenced by its structural properties, including polarity, the potential for hydrogen bonding, and the solvent environment. This multi-faceted nature truly illustrates the complexity of predicting solubility in chemical compounds.

Interesting facts

Interesting Facts about (3S)-3-(1-benzyl-4-piperidyl)-3-phenyl-piperidine-2,6-dione

This intriguing compound, known as a piperidine derivative, holds a significant place in medicinal chemistry due to its potential pharmacological properties. Here are some key points that highlight its importance:

  • Structural Diversity: The presence of a piperidine ring fused with various functional groups and side chains showcases the compound's structural diversity. This complexity often correlates with diverse biological activities.
  • Potential Therapeutic Applications: Research has suggested that compounds similar to (3S)-3-(1-benzyl-4-piperidyl)-3-phenyl-piperidine-2,6-dione may exhibit efficacy as pharmaceutical agents, particularly in the treatment of neurological disorders.
  • Chirality: This compound is chiral, meaning it has an enantiomer, which can lead to different biological effects. In drug design, chirality is a crucial factor in determining the efficacy and safety of compounds.
  • Influence on Receptors: Compounds with benzyl and piperidine groups are often investigated for their interactions with neurotransmitter receptors, highlighting their potential role in modulating neurotransmission.
  • Research and Development: Ongoing research may reveal more about how modifications to this compound can enhance its therapeutic profiles, making it an exciting subject for further study.

As a compound with promising implications, (3S)-3-(1-benzyl-4-piperidyl)-3-phenyl-piperidine-2,6-dione is a shining example of how structural modifications can lead to significant advancements in medicinal chemistry. Its exploration in both laboratory and clinical settings continues to unveil new possibilities in drug development.

Synonyms
DEXETIMIDE
21888-98-2
Dexetimida
(+)-Benzetimide
Benzetimide, (s)-
Dexbenzetimide
Dexetimidum
R 16470
43477QYX3D
(3,4'-Bipiperidine)-2,6-dione, 3-phenyl-1'-(phenylmethyl)-, (S)-
R-16470 FREE BASE
R 16,470 FREE BASE
DTXSID701043218
Dexbenzetimid
dextro-Benzetimide
dextro Benzetimide
(3S)-3-phenyl-3-(1-(phenylmethyl)piperidin-4-yl)piperidine-2,6-dione
(3S)-3-phenyl-3-[1-(phenylmethyl)piperidin-4-yl]piperidine-2,6-dione
RefChem:585861
R16470
N04AA08
DTXCID701525917
(3S)-1'-benzyl-3-phenyl-(3,4'-bipiperidine)-2,6-dione
Tremblex
(3S)-3-(1-benzylpiperidin-4-yl)-3-phenylpiperidine-2,6-dione
[3,4'-Bipiperidine]-2,6-dione, 3-phenyl-1'-(phenylmethyl)-, (3S)-
R 16,470 [as hydrochloride]
(+)-2-(1-Benzyl-4-piperidyl)-2-phenylglutarimide
Dexbenzelimid
Serenone
Dexetimidum [INN-Latin]
Dexetimida [INN-Spanish]
DEXETIMIDE [MI]
DEXETIMIDE [INN]
Dexetimide (USAN/INN)
DEXETIMIDE [USAN]
DEXETIMIDE [MART.]
DEXETIMIDE [WHO-DD]
GTPL354
Dexetimide [USAN:INN:BAN]
SCHEMBL148329
UNII-43477QYX3D
orb1707385
R-16470 [as hydrochloride]
CHEMBL1908364
CHEBI:135531
BDBM50228206
PDSP1_000518
PDSP2_000516
AKOS040741626
DB08997
MS-25764
HY-105545
CS-0026226
D03711
G12551
Q904647
(S)-1'-Benzyl-3-phenyl-[3,4'-bipiperidine]-2,6-dione
(+)-(R)-3-(1-Benzyl-4-piperidyl)-3-phenyl-2,6-piperidindion